Abstract
Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for development of the clocks.
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Supported by NIH grants.
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Podolskiy, D.I., Gladyshev, V.N. (2019). DNA Methylation Markers to Assess Biological Age. In: Moskalev, A. (eds) Biomarkers of Human Aging. Healthy Ageing and Longevity, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-030-24970-0_12
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DOI: https://doi.org/10.1007/978-3-030-24970-0_12
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