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Extracorporeal Cellular Liver Assisted Devices

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Liver Diseases

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Abstract

The current definitive management of acute liver failure and acute on chronic liver failure is liver transplantation. However, because of organ shortages, other modalities of therapy are necessary as a possible bridge. This chapter discusses the current state of extracorporeal cellular (bioartificial) liver assist devices including Extracorporeal Liver Assist Device (ELAD), HepatAssist, Modular Extracorporeal Liver Support System (MELS), and the Bioartificial Liver Support System (BLSS). An overview of the circuit as well as outcomes of studies done using these devices will be provided.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Rutgers—New Jersey Medical School, Newark, NJ, USA

    Pavan Patel & Nikolaos T. Pyrsopoulos

Authors
  1. Pavan Patel
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  2. Nikolaos T. Pyrsopoulos
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Corresponding author

Correspondence to Nikolaos T. Pyrsopoulos .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, “Titu Maiorescu” University, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Florentina Radu-Ionita

  2. New Jersey Medical School, Rutgers University New Jersey Medical School, Newark, NJ, USA

    Nikolaos T. Pyrsopoulos

  3. Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Mariana Jinga

  4. Faculty of Medicine, “Titu Maiorescu” University, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Ion C. Tintoiu

  5. Medical Radiation Sciences, Curtin University, Perth, WA, Australia

    Zhonghua Sun

  6. “Prof. C.C. Iliescu” Emergency Institute for Cardiovascular Diseases, Bucharest, Romania

    Ecaterina Bontas

Self Study

Self Study

1.1 Question

  1. 1.

    Which statement is true?

    1. (a)

      ELAD employs the use of porcine hepatocytes

    2. (b)

      MELS employs the use of only porcine hepatocytes

    3. (c)

      HepatAssist employs the use of porcine hepatocytes

    4. (d)

      BLSS uses plasma for exchange

1.2 Answer

  1. 1.

    Which statement is true?

    1. (a)

      ELAD uses human hepatoblastoma cells not porcine hepatocytes

    2. (b)

      MELS uses both porcine and human hepatocytes

    3. (c)

      CORRECT ANSWER. HepatAssist uses porcine hepatocytes

    4. (d)

      BLSS uses whole blood for exchange not plasma

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Patel, P., Pyrsopoulos, N.T. (2020). Extracorporeal Cellular Liver Assisted Devices. In: Radu-Ionita, F., Pyrsopoulos, N., Jinga, M., Tintoiu, I., Sun, Z., Bontas, E. (eds) Liver Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-24432-3_67

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  • DOI: https://doi.org/10.1007/978-3-030-24432-3_67

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-24431-6

  • Online ISBN: 978-3-030-24432-3

  • eBook Packages: MedicineMedicine (R0)

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