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Early Mechanisms of Cardiac Development

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Heart of the Matter

Part of the book series: Learning Materials in Biosciences ((LMB))

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Abstract

This chapter initially introduces the importance of animal models in understanding cardiac development. We will discuss the early stages of embryonic development, including gastrulation, formation of the linear heart tube and the looping process. We will then explore the concept of the organiser during early vertebrate development using the example of the Spemann-Mangold organiser of the amphibian embryo. Finally, we will expand on how cells in the embryo are able to interpret morphogen gradients by introducing the French Flag Model.

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Author information

Authors and Affiliations

  1. Imperial College London, London, UK

    Jack Griffiths

  2. National Heart and Lung Institute, Myocardial Function, Imperial College London, London, UK

    Thomas Brand

Authors
  1. Jack Griffiths
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  2. Thomas Brand
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Corresponding author

Correspondence to Thomas Brand .

Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College London, London, UK

    Cesare Terracciano

  2. Imperial College London & St George’s Medical School, London, UK

    Samuel Guymer

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Griffiths, J., Brand, T. (2019). Early Mechanisms of Cardiac Development. In: Terracciano, C., Guymer, S. (eds) Heart of the Matter. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-24219-0_2

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