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The Coagulation Cascade and its Therapeutic Modulation

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Part of the book series: Learning Materials in Biosciences ((LMB))

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Abstract

This chapter will provide a comprehensive overview of both primary and secondary haemostasis at a gross and molecular level, in addition to examining the relevant signalling and cellular mediators of these dual processes. We will then discuss three key regulatory mechanisms, whilst simultaneously exploring the clinical relevance of both the aforementioned mechanisms and the aberrance of coagulation.

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Author information

Authors and Affiliations

  1. Imperial College London, London, UK

    Lieze Thielemans & Moghees Hanif

  2. Queen Mary University of London, London, UK

    Moghees Hanif

  3. Centre for Haematology, Imperial College London, London, UK

    James Crawley

Authors
  1. Lieze Thielemans
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  2. Moghees Hanif
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  3. James Crawley
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Corresponding author

Correspondence to James Crawley .

Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College London, London, UK

    Cesare Terracciano

  2. Imperial College London & St George’s Medical School, London, UK

    Samuel Guymer

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Thielemans, L., Hanif, M., Crawley, J. (2019). The Coagulation Cascade and its Therapeutic Modulation. In: Terracciano, C., Guymer, S. (eds) Heart of the Matter. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-24219-0_16

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