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Heart of the Matter pp 135–144Cite as

The Scientific Basis of Heart Failure

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Abstract

The aim of this chapter is to discuss the current literature surrounding the science that underlies heart failure. This encompasses the natural history of the syndrome, namely, an initial myocardial insult, apparent recovery, decompensation and finally failure of the organ. We will then expand upon some of the post-infarction changes to ventricular performance in both the compensatory and failure stages, including their manifestations on the Frank–Starling curve. Finally, the topic of cardiac regeneration will briefly be analysed. Understanding the science behind regeneration will provide a foundation to appreciate the basis of novel therapies, discussed later.

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Author information

Authors and Affiliations

  1. Imperial College London, London, UK

    Giles Chick

  2. National Heart and Lung Institute, Myocardial Function, Imperial College London, London, UK

    Fotios G. Pitoulis & Liam Couch

Authors
  1. Giles Chick
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  2. Fotios G. Pitoulis
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  3. Liam Couch
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Corresponding author

Correspondence to Liam Couch .

Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, Imperial College London, London, UK

    Cesare Terracciano

  2. Imperial College London & St George’s Medical School, London, UK

    Samuel Guymer

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Chick, G., Pitoulis, F.G., Couch, L. (2019). The Scientific Basis of Heart Failure. In: Terracciano, C., Guymer, S. (eds) Heart of the Matter. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-24219-0_11

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