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Mast Cells in Tumor Fate

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Abstract

It is now well documented that neoplastic cells are influenced by their microenvironment and viceversa. The specific organ microenvironment determines the extent of cancer cell proliferation, angiogenesis, invasion and survival.

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References

  • Aaltomaa S, Lipponen P, Papinaho S et al (1993) Mast cells in breast cancer. Anticancer Res 13:785–788

    CAS  PubMed  Google Scholar 

  • Baram D, Vaday G, Salamon P et al (2001) Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha. J Immunol 167:4008–4016

    Article  CAS  Google Scholar 

  • Bingle L, Brown NJ, Lewis CE (2002) The role of tumor associated macrophages in tumor progression: implications for new anticancer therapies. J Pathol 196:254–265

    Article  CAS  Google Scholar 

  • Caplan RM (1963) The natural course of urticaria pigmentosa. Arch Dermatol 87:146–157

    Article  CAS  Google Scholar 

  • Chan JK, Magistris A, Loizzi V et al (2005) Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer. Gynecol Oncol 99:20–25

    Article  CAS  Google Scholar 

  • Conti P, Pang X, Boucher W et al (1997) Impact of rantes and MCP-1 chemokines on in vivo basohilic mast cell recruitment in rat skin injection model and their role in modifying the protein and mrna levels for histidine decarboxylase. Blood 89:4120–4127

    CAS  PubMed  Google Scholar 

  • Dabbous M, Walker R, Haney L et al (1986) Mast cells and matrix degradation at sites of tumor invasion in rat mammary adenocarcinoma. Br J Cancer 54:459–465

    Article  CAS  Google Scholar 

  • Dabiri S, Huntsman D, Makretsov N et al (2004) The presence of stromal mast cells identifies a subset of invasive breast cancers with a favorable prognosis. Mod Pathol 17:690–695

    Article  Google Scholar 

  • Dave SS, Wright G, Than B et al (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infilitrating immune cells. N Engl J Med 351:2159–2169

    Article  CAS  Google Scholar 

  • Fukushima N, Satoh T, Sano M et al (2001) Angiogenesis and mast cell in non hodgkin’s lymphoma; a strong correlation in angioimmunoblastic T-cell lymphoma. Leuk Lymphoma 42:709–720

    Article  CAS  Google Scholar 

  • Fukushima H, Ohsawa M, Ikura Y et al (2006) Mast cells in diffuse large B-cell lymphoma; their role in fibrosis. Histopathology 49:498–505

    Article  CAS  Google Scholar 

  • Gooch SJ, Lee AV, Yee D (1998) Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. Cancer Res 58:4199–4205

    CAS  PubMed  Google Scholar 

  • Gruber BL, Marchese MJ, Kaw R (1995) Angiogenic factors stimulate mast cell migration. Blood 86:2488–2493

    CAS  PubMed  Google Scholar 

  • Guidolin D, Nico B, Crivellato E et al (2008) Tumoral mast cells exhibit a common spatial distribution. Cancer Lett 273:80–85

    Article  Google Scholar 

  • Hara M, Matsumori A, Ono K et al (1999) Mast cells cause apotosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro. Circulation 100:1443–1449

    Article  CAS  Google Scholar 

  • He S, Walls AF (1998) Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 125:1491–1500

    Article  CAS  Google Scholar 

  • Ho KL (1984) Ultrastructure of cerebellar capillary hemangioblastoma. II. Mast Cells and Angiogenesis. Acta Neuropathol 64:308–318

    Article  CAS  Google Scholar 

  • Iamaroon A, Pongsiriwet S, Jittidecharaks S et al (2003) Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma. J Oral Pathol Med 32:195–199

    Article  Google Scholar 

  • Jenkins DC, Charles IG, Thompson LL et al (1995) Role of nitric oxide in tumor growth. Proc Natl Acad Sci USA 92:4392–4396

    Article  CAS  Google Scholar 

  • Kankkunen JP, Harvima IT, Naukkarinen A (1997) Qunatitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions. Int J Cancer 72:385–388

    Article  CAS  Google Scholar 

  • Leek RD, Lander RJ, Harris AL et al (1999) Necrosis correlates with high vascular density and focal macrophages infiltration in invasive carcinoma of the breast. Br J Cancer 79:991–995

    Article  CAS  Google Scholar 

  • Lennert K, Parwaresch MR (1979) Mast cells and mast cell neoplasia: a review. Histopathology 3:349–365

    Article  CAS  Google Scholar 

  • Liotta L, Kohn EC (2001) The microenvironment of the tumor-host interface. Nature 411:375–379

    Article  CAS  Google Scholar 

  • Maślińska D, Woźniak R, Kaliszek A et al (1999) Phenotype of mast cells in the brain tumor. Capillary Hemangioblastoma. Folia Neuropathol 37:138–142

    PubMed  Google Scholar 

  • Molin D (2004) Bystander cells and prognosis in Hodgkin lymphoma. Review based on a doctoral thesis. Ups J Med Sci 109:179–228

    Article  Google Scholar 

  • Molin D, Edstrom A, Glimelius I et al (2002) Mast cell infilitration correlates with poor prognosis in hodgkin’s lymphoma. Br J Haematol 119:122–124

    Article  Google Scholar 

  • Nechushtan H, Razin E (2002) The function of MIFT and associated proteins in mast cells. Mol Immunol 38:1177–1180

    Article  CAS  Google Scholar 

  • Nonomura N, Takayama H, Nishimura K et al (2007) Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer. Br J Cancer 97:952–956

    Article  CAS  Google Scholar 

  • Ohno S, Inagawa H, Soma G et al (2002) Role of tumor-associated macrophage in malignant tumors: should the location of the infiltrated macrophages be taken into account during evaluation? Anticancer Res 22:4269–4275

    CAS  PubMed  Google Scholar 

  • Park CC, Bissell MJ, Barcellos-Hoff MH (2000) The influence of the microenvironment on the malignant phenotype. Mol Med Today 6:324–329

    Article  CAS  Google Scholar 

  • Polajeva J, Sjosten AM, Lager N et al (2011) Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS ONE 6:e25222

    Article  CAS  Google Scholar 

  • Reszec J, Hermanowicz A, Rutkowski R et al (2013) Evaluation of mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema. J Neurooncol 115:119–125

    Article  CAS  Google Scholar 

  • Rojas IG, Spencer ML, Martinez A et al (2005) Characterization of mast cell subpopulations in lip cancer. J Oral Pathol Med 34:268–273

    Article  CAS  Google Scholar 

  • Samoszuk M, Corwin M (2003) Mast cell inhibitor cromolyn increases blood clotting and hypoxia in murine breast cancer. Int J Cancer 107:159–163

    Article  CAS  Google Scholar 

  • Sharma VK, Agrawal AK, Pratarp VK et al (1992) Mast cell reactivity in lymphoma: a preliminary communication. Indian J Cancer 29:61–65

    CAS  PubMed  Google Scholar 

  • Stack MS, Johnson DA (1994) Human mast cell tryptase activates single-chain urinary-type plasminogen activator (pro-urokinase). J Biol Chem 269:9416–9419

    CAS  PubMed  Google Scholar 

  • Theoharides T, Conti P (2004) Mast cells: the jekyll and hyde of tumor growth. Trends Immunol 25:235–241

    Article  CAS  Google Scholar 

  • Theoharides TC, Kempuraj D, Tagen M et al (2007) Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev 217:65–78

    Article  CAS  Google Scholar 

  • Theoharides TC, Rozniecki JJ, Sahagian G et al (2008) Impact of stress and mast cells on brain metastases. J Neuroimmunol 205:1–7

    Article  CAS  Google Scholar 

  • Thoresen S, Tangen M, Hartveit F (1982) Mast cells in the axillary nodes of breast cancer patients. Diagn Histopathol 5:65–67

    CAS  PubMed  Google Scholar 

  • Torunilhac O, Santos DD, Xu L et al (2006) Mast cells in waldenstrom’s macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol 17:1275–1282

    Article  Google Scholar 

  • Travis WD, Li CY, Yam LT et al (1988) Significance of systemic mast cell disease with associated hematologic disorders. Cancer 62:965–972

    Article  CAS  Google Scholar 

  • Welsh TJ, Green RH, Richardson D et al (2005) Macrophage and mast cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 23:8959–8967

    Article  Google Scholar 

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Correspondence to Domenico Ribatti .

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Ribatti, D. (2019). Mast Cells in Tumor Fate. In: The Mast Cell . Springer, Cham. https://doi.org/10.1007/978-3-030-24190-2_10

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