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P53 and Apoptosis in the Drosophila Model

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The Drosophila Model in Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1167))

Abstract

Human P53 (HsP53) is the most frequently mutated gene associated with cancers. Despite heightened research interest over the last four decades, a clear picture of how wild type HsP53 functions as the guardian against malignant transformation remains elusive. Studying the ortholog of P53 in the genetic model organism Drosophila melanogaster (DmP53) has revealed many interesting insights. This chapter focuses on recent findings that have shed light on how DmP53 -mediated apoptosis plays an important role in maintaining genome integrity, and how the immediate output of activated DmP53 is determined by the epigenetic landscape of individual cells.

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Acknowledgement

Research work in the author’s lab was supported in part by NIH grants GM106174 & GM110477. The author is grateful for helpful comments and editing by Jasmine Ayers and Haya Ghannouma.

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Authors and Affiliations

  1. Department of Molecular Genetics and Microbiology, UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, FL, USA

    Lei Zhou

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  1. Lei Zhou
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Correspondence to Lei Zhou .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Tulane Cancer Center, LCRC, Tulane University School of Medicine, New Orleans, LA, USA

    Wu-Min Deng

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Zhou, L. (2019). P53 and Apoptosis in the Drosophila Model. In: Deng, WM. (eds) The Drosophila Model in Cancer. Advances in Experimental Medicine and Biology, vol 1167. Springer, Cham. https://doi.org/10.1007/978-3-030-23629-8_6

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