Abstract
Among gonococcal and nongonococcal bacterial infections, septic arthritis continues to be a medical emergency, and diagnosis continues to be challenging. When assessing a patient with clinical features such as acute onset of localized joint pain, tenderness, swelling, and decreased joint motion, it is important to keep in mind infectious arthritis. Infectious arthritis is caused by bacteria, fungi, mycobacteria, and viruses. However, bacterial infectious arthritis is classically divided into gonococcal and nongonococcal arthritis.
Typical risk factors for the development of septic arthritis include previous joint pathology (e.g., rheumatoid arthritis, osteoarthritis), joint prosthesis, intravenous drug abuse, alcoholism, systemic disorders, skin infections, previous intra-articular injection, or arthroscopy.
Diagnosis is still mainly based on isolating the pathogen; treatment must begin immediately with a broad spectrum antibiotic until a particular pathogen is isolated. Prognosis depends on early diagnosis and appropriate antibiotic therapy because delay in diagnosis and treatment can lead to irreversible joint damage and increase complications. Treatment often requires a multidisciplinary approach involving orthopedic surgery, infectious disease evaluation, and physical therapy. Here, we present a brief review of the most common types of bacterial infectious arthritis: gonococcal or nongonococcal.
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References
Atkins BL, Bowler IC. The diagnosis of large joint sepsis. J Hosp Infect. 1998;40:263–74.
Goldenberg DL, Chisholm PL, Rice PA. Experimental models of bacterial arthritis: a microbiologic and histopathologic characterization of the arthritis after the intraarticular injections of Neisseria gonorrhoeae, Staphylococcus aureus, group A streptococci, and Escherichia coli. J Rheumatol. 1983;10:5–11.
Schurman DJ, Mirra J, Ding A, Nagel DA. Experimental E. coli arthritis in the rabbit. A model of infectious and post-infectious inflammatory synovitis. J Rheumatol. 1977;4:118–28.
Goldenberg DL, Cohen AS. Acute infectious arthritis. A review of patients with a non-gonococcal joint infection. Am J Med. 1976;60:369–77.
Roca RP, Yoshikawa TT. Primary skeletal infections in heroin users: a chemical characterization, diagnosis and therapy. Clin Orthop. 1979;144:238–48.
Mitchell WS, Brooks PM, Stevenson RD, Buchanan WW. Septic arthritis in patients with rheumatoid disease: a still under-diagnosed complication. J Rheumatol. 1976;3:124–33.
Douglas GW, Levin RU, Sokololf L. Infectious arthritis complicating neoplastic disease. N Engl J Med. 1964;270:299–302.
Franz A, Webster AD, Furr PM, Taylor-Robinson D. Mycoplasmal arthritis in patients with primary immunoglobulin deficiency: clinical features and outcome in 18 patients. Br J Rheumatol. 1997;36:661–8.
Kaandorp CJ, Van Schaardenburg D, Krijnen P, Habbema JD, van de Laar MA. Risk factors for septic arthritis in patients with joint disease: a prospective study. Arthritis Rheum. 1995;38:1819–25.
Mathews CJ, Weston VC, Jones A, Field M, Coakley G. Bacterial septic arthritis in 387 adults. Lancet. 2010;375:846–55.
Cooper C, Cawley MID. Bacterial arthritis in an English health district: a 10-year review. Ann Rheum Dis. 1986;45:458–63.
Woo PC, Lau SK, Yuen KY. First report of methicillin-resistant Staphylococcus aureus septic arthritis complicating acupuncture: simple procedure resulting in most devastating outcome. Diagn Microbiol Infect Dis. 2009;63:92–5.
Armstrong RW, Bolding F, Joseph R. Septic arthritis following arthroscopy: clinical syndromes and analysis of risk factors. Arthroscopy. 1992;8:213–23.
Klein DM, Barbera C, Gray ST, Spero CR, Perrier G, Teicher JL. Sensitivity of objective parameters in the diagnosis of pediatric septic hips. Clin Orthop. 1997;338:153–9.
Kallio MJ, Unkila-Kallio L, Aalto K, Peltola H. Serum C-reactive protein, erythrocyte sedimentation rate and white blood cell count in septic arthritis of children. Pediatr Infect Dis J. 1997;16:411–3.
Wilkins RF, Healy RA, Decker JL. Acute infectious arthritis in the aged and chronically ill. Arch Intern Med. 1996;106:354–67.
Brucellosis in Britain [editorial]. BMJ. 1984;289:817.
Trujillo IZ, Zavala AN, Caceres JG, Miranda CQ. Brucellosis. Infect Dis Clin N Am. 1994;8:225–41.
Hasley JP, Reebak JS, Barnes CG. A decade of skeletal tuberculosis. Ann Rheum Dis. 1982;41:7–10.
Niall DM, Murphy PG, Fogarty EE, Dowling FE, Moore DP. Puncture wound related pseudomonas infections of the foot in children. Ir J Med Sci. 1997;166:98–101.
Allison DC, Holtom PD, Patzakis MJ, Zalavras CG. Microbiology of bone and joint infections in injecting drug abusers. Clin Orthop Relat Res. 2010;468:2107–399.
Kaandorp CJ, Dinant HJ, Van de Laar MA, Moens HJ, Prins AP, Dijkmans BA. Incidence and sources of native and prosthetic joint infection: a community based prospective survey. Ann Rheum Dis. 1997;56:470–5.
Kaandorp CJ, Krijnen P, Moens HJ, Habbema JD, van Schaardenburg D. The outcome of bacterial arthritis: a prospective community-based study. Arthritis Rheum. 1997;40:884–92.
Favero M, Schiavon F, Riato L, Carraro V, Punzi L. Rheumatoid arthritis is the major risk factor for septic arthritis in rheumatological settings. Autoimmun Rev. 2008;8:59–61.
García-De La Torre I. Advances in the management of septic arthritis. Rheum Dis Clin N Am. 2003;29(1):61–75.
Goldenberg DL, Reed JI. Bacterial arthritis. N Engl J Med. 1985;312:764–71.
Goldenberg DL. Septic arthritis. Lancet. 1998;351:197–202.
De Champs C, Le Seaux S, Dubost JJ, Boisgard S, Sauvezie B, Sirot J. Isolation of Pantoea agglomerans in two cases of septic monoarthritis after plant thorn and wood sliver injuries. J Clin Microbiol. 2000;38:460–1.
Tong DC, Rothwell BR. Antibiotic prophylaxis in dentistry: a review and practice recommendations. J Am Dent Assoc. 2000;131:366–74.
Haug JB, Harthug S, Kalager T, Digranes A, Solberg CO. Bloodstream infections at a Norwegian university hospital, 1974–1979 and 1988–1989: changing etiology, clinical features, and outcome. Clin Infect Dis. 1994;19:246–56.
Ross JJ, Saltzman CL, Carling P, Shapiro DS. Pneumococcal septic arthritis: review of 190 cases. Clin Infect Dis. 2003;36:319–27.
Patti JM, Bremell T, Krajewska-Pietrasik D, Abdelnour A, Tarkowski A, Rydén C, Höök M. The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis. Infect Immun. 1994;62:152–61.
Stevens CR, Williams RB, Farrell AJ, Blake DR. Hypoxia and inflammatory synovitis: observations and speculation. Ann Rheum Dis. 1991;50:124–32.
Matthews PC, Dean BJ, Medagoda K, Gundle R, Atkins BL, Berendt AR, Byren I. Native hip joint septic arthritis in 20 adults: delayed presentation beyond three weeks predicts need for excision arthroplasty. J Infect. 2008;57:185–90.
Dubost JJ, Fis I, Denis P, Lopitaux R, Soubrier M, Ristori JM, et al. Polyarticular septic arthritis. Medicine. 1993;72:296–310.
Shirtliff ME, Mader JT. Acute septic arthritis. Clin Microbiol Rev. 2002;15:527–44.
Weston VC, Jones AC, Bradbury N, Fawthrop F, Doherty M. Clinical features and outcome of septic arthritis in a single UK Health District 1982–1991. Ann Rheum Dis. 1999;58:214–9.
Edwards SA, Cranfield T, Clarke HJ. Atypical presentation of septic arthritis in the immunosuppressed patient. Orthopedics. 2002;25:1089–90.
Brown TJ, Yen-Moore A, Tyring SK. An overview of sexually transmitted diseases, part I. J Am Acad Dermatol. 1999;41:511–32.
Cucurull E, Espinoza LR. Gonococcal arthritis. Rheum Dis Clin N Am. 1998;24:305–22.
Al-Suleiman SA, Grimes EM, Jonas HS. Disseminated gonococcal infections. Obstet Gynecol. 1983;61:48–51.
Bardin T. Gonococcal arthritis. Best Pract Res Clin Rheumatol. 2003;17:201–8.
O’Brien JP, Goldenberg DL, Rice PA. Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine (Baltimore). 1983;62:395–406.
Wise CM, Morris CR, Wasilauskas BL, Salzerl WL. Gonococcal arthritis in an era of increasing penicillin resistance: presentations and outcomes in 41 recent cases (1985–1991). Arch Intern Med. 1994;154:2690–5.
Newman ED, Davis DE, Harrington TM. Septic arthritis due to gram negative bacilli: older patients with good outcome. J Rheumatol. 1988;15:659–62.
Pioro MH, Mandell BF. Septic arthritis. Rheum Dis Clin N Am. 1997;23:239–58.
Rice PA. Gonococcal arthritis (disseminated gonococcal infection). Infect Dis Clin N Am. 2005;19:853–61.
Tuttle CSL, Van Dantzig T, Brady S, Ward J, Maguire G. The epidemiology of gonococcal arthritis in an Indigenous Australian population. Sex Transm Infect. 2015;0:1–5. https://doi.org/10.1136/sextrans-2014-051893.
Wind CM, de Vries HJ, Schim van der Loeff MF, Unemo M, van Dam AP. Successful combination of nucleic acid amplification test diagnostics and targeted deferred Neisseria gonorrhoeae culture. J Clin Microbiol. 2015;53(6):1884–90. https://doi.org/10.1128/JCM.00369-15.
Schattner A, Vosti KL. Bacterial arthritis due to beta-hemolytic streptococci of serogroups A, B, C, F, and G: analysis of 23 cases and review of the literature. Medicine. 1998;77:122–39.
Dugan JM, Geogiades G, VanGorp C, Kleshinski J. Group B streptococcal prosthetic joint infections. J South Orthop Assoc. 2001;10(4):209–14.
Goldenberg DL, Brandt KD, Cathcart ES, Cohen AS. Acute arthritis caused by gram-negative bacilli: a clinical characterization. Medicine. 1974;53:197–208.
Ho G Jr. Bacterial arthritis. In: McCarty DJ, Koopman WJ, editors. Arthritis and allied conditions. 12th ed. Philadelphia: Lea and Febiger; 1993. p. 2003–23.
Zimmermann B 3rd, Mikolich DJ, Lally EV. Septic sacroiliitis. Semin Arthritis Rheum. 1996;26:592–604.
Sanchez RB, Quinn SF. MRI of inflammatory synovial processes. Magn Reson Imaging. 1989;7:529–40.
Widman DS, Craig JG, Van Holsbeeck MT. Sonographic detection, evaluation and aspiration of infected acromioclavicular joints. Skelet Radiol. 2001;30:388–92.
Hamed KA, Tam JY, Prober CG. Pharmacokinetic optimisation of the treatment of septic arthritis. Clin Pharmacokinet. 1996;21:156–63.
Le Dantec L, Maury F, Flipo RM, Laskri S, Cortet B, Duquesnoy B, Delcambre B. Peripheral pyogenic arthritis. A study of one hundred seventy-nine cases. Rev Rhum Engl Ed. 1996;63:103–10.
Centers for Disease Control and Prevention (CDC). Update to CDC’s sexually transmitted diseases treatment guidelines 2006: fluoroquinolones no longer recommended for treatment of gonococcal infections. Morb Mortal Wkly Rep. 2007;56:332–6.
Ross JJ, Shamsuddin H. Sternoclavicular septic arthritis: review of 180 cases. Medicine (Baltimore). 2004;83:139–48.
Broy SB, Schmid FR. A comparison of medical drainage (needle aspiration) and surgical drainage (arthrotomy or arthroscopy) in the initial treatment of infected joints. Clin Rheum Dis. 1986;12:501–22.
Tarkowski A. Infectious arthritis. Best Pract Res Clin Rheumatol. 2006;20:1029–44.
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García-De La Torre, I., González-Bello, Y.C. (2019). Gonococcal and Nongonococcal Bacterial Infections. In: Espinoza, L. (eds) Infections and the Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-23311-2_3
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