Skip to main content
SpringerLink
Log in

Leprosy-Associated Arthritis

  • Chapter
  • First Online:
Infections and the Rheumatic Diseases

  • 756 Accesses

Abstract

The various clinical presentations of leprosy are associated with osteoarticular manifestations, some transient and some permanent associated with irreversible damage. In this chapter, we review the different clinical presentations, new advances in pathogenesis and autoimmune manifestations, and recent therapies for cases that failed with corticosteroids and thalidomide treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Britton WJ, Lockwood DN. Leprosy. Lancet. 2004;363(9416):1209–19.

    Article  Google Scholar 

  2. Rodrigues LC, Lockwood DNJ. Leprosy now: epidemiology, progress, challenges and research gaps. Lancet Infect Dis. 2011;11:464–70.

    Article  Google Scholar 

  3. World Health Organization. Weekly epidemiological record (Internet). Geneva: World Health Organization; 2017.. (cited 2018 jan 17). 22p.

    Google Scholar 

  4. Yamamura M, Wang XH, Ohmen JD, Uyemura K, Rea TH, Bloom BR, Modlin RL. Cytokine patterns of immunologically mediated tissue damage. J Immunol. 1992;149(4):1470–5.

    CAS  PubMed  Google Scholar 

  5. Negera E, Bobosha K, Walker SL, Endale B, et al. New insight into the pathogenesis of erythema nodosum leprosum: the role of activated memory T-cells. Front Immunol. 2017;8:1149.

    Article  Google Scholar 

  6. Negera E, Walker SL, Bobosha K, Howe R, Aseffa A, Dockrell HM, Lockwood DN. T-cell regulation in erythema nodosum leprosum. PLoS Negl Trop Dis. 2017;11(10):e0006001. https://doi.org/10.1371/journal.pntd.0006001. eCollection 2017 Oct.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five group system. Int J Lepr Other Mycobact Dis. 1966;34(3):255–73.

    CAS  PubMed  Google Scholar 

  8. Ambrosano L, Santos MASD, Machado ECFA, Pegas ES. Epidemiological profile of leprosy reactions in a referral center in Campinas (SP), Brazil, 2010-2015. An Bras Dermatol. 2018;93(3):460–1. https://doi.org/10.1590/abd1806-4841.20187260.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy reaction in Thai population: a 20-year retrospective study. Dermatol Res Pract. 2015;2015:253154. https://doi.org/10.1155/2015/253154. Epub 2015 Oct 5.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Cossermelli-Messina W, Festa Neto C, Cossermelli W. Articular inflammatory manifestations in patients with different forms of leprosy. J Rheumatol. 1998;25(1):111–9.

    CAS  PubMed  Google Scholar 

  11. Foss NT. Episódios reacionais na hanseníase. Medicina. 2003;36(2/4):453–9.

    Google Scholar 

  12. Holla VV, Kenetker MV, Kolhatkar MK, et al. Leprous synovitis. A study of fifty cases. Int J Lepr Other Mycobact Dis. 1983;51(1):29–32.

    CAS  PubMed  Google Scholar 

  13. Modi TH, Lele RD. Acute joint manifestations in leprosy. J Assoc Phys India. 1968;7:247–54.

    Google Scholar 

  14. Pereira HL, Ribeiro SL, Pennini SN, et al. Leprosy-related joint involvement. Clin Rheumatol. 2009;28:79–84.

    Article  CAS  Google Scholar 

  15. Wakhlu A, Sawlani KK, Himanshu D. Rheumatological manifestations of Hansen’s disease. Indian J Rheumatol. 2018;13:14–9.

    Article  Google Scholar 

  16. Guedes Barbosa LS, Gilbrut B, Shoenfeld Y, Scheinberg MA. Autoantiboides in leprosy sera. Clin Rheumatol. 1996;15:26–8.

    Article  CAS  Google Scholar 

  17. Edington FL, Bacellar MO, Machado PR, Barbosa L, Reis E, Reis M, Santiago MB. Anti neutrophil cytoplasmic antibodies in leprosy. Clin Rheumatol. 2007;26(2):208–10.

    Article  Google Scholar 

  18. Chao G, Fang L, Lu C. Leprosy with ANA positive mistaken for connective tissue disease. Clin Rheumatol. 2013;32(5):645–8.

    Article  Google Scholar 

  19. Ribeiro SL, Pereira HL, Silva NP, Sato EI, et al. Long-term persistence of anti-β2 glycoprotein I in treated leprosy patients. Lupus. 2014;23(12):1249–51.

    Article  CAS  Google Scholar 

  20. Ribeiro SL, Pereira HL, Mangueira CL, Ferreira CE, Rosseto E, Scheinberg M. The development of arthritis and antinuclear antibodies correlate with serum 25-hydroxyvitamin D levels in patients with leprosy. Ann Rheum Dis. 2012;71(12):2062–3.

    Article  CAS  Google Scholar 

  21. Ribeiro SL, Pereira HL, Silva NP, Neves RM, Sato EI. Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement. Braz J Med Biol Res. 2008;41(11):1005–10.

    Article  CAS  Google Scholar 

  22. Guedes-Barbosa LS, Mangueira C, Scheinberg M. Anticitrulline peptide antibodies (CCP3) in leprosy sera: a negative association. Clin Rheumatol. 2008;27(4):515–6.

    Article  Google Scholar 

  23. Gilburd B, Ziporen L, Zharhary D, Blank M, et al. Antimitochondrial (pyruvate dehydrogenase) antibodies in leprosy. J Clin Immunol. 1994;14(1):14–9.

    Article  CAS  Google Scholar 

  24. Dionello CF, Rosa Utiyama SR, Radominski SC, Stahlke E, Stinghen ST, de Messias-Reason IJ. Evaluation of rheumatoid factor and anti-citrullinated peptide antibodies in relation to rheumatological manifestations in patients with leprosy from Southern Brazil. Int J Rheum Dis. 2016;19(10):1024–31.

    Article  CAS  Google Scholar 

  25. Negera E, Walker SL, Lema T, Aseffa A, Lockwood DN, Dockrell HM. Complement C1q expression in erythema nodosum leprosum. PLoS Negl Trop Dis. 2018;12(3):e0006321. https://doi.org/10.1371/journal.pntd.0006321. eCollection 2018 Mar.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Lugão HB, Frade MA, Marques W Jr, Foss NT, Nogueira-Barbosa MH. Ultrasonography of leprosy neuropathy: a longitudinal prospective study. PLoS Negl Trop Dis. 2016;10(11):e0005111.

    Article  Google Scholar 

  27. Beltrame A, Barabino G, Cicciò C, Badona Monteiro G, Cavalchini A, Carbognin G, Bisoffi Z. Magnetic resonance imaging in pure neural leprosy. Int J Infect Dis. 2017;60:42–3.

    Article  Google Scholar 

  28. Roy SG, Parida GK, Tripathy S, Das CJ, Kumar R, Roy SG, Parida GK, Tripathy S, Das CJ, Kumar R. Active leprosy neuritis detected on FDG PET/CT. Clin Nucl Med. 2018;43(2):132–3.

    Article  Google Scholar 

  29. Faber WR, Jensema AJ, Goldschmidt WF. Treatment of recurrent erythema nodosum leprosum with infliximab. N Engl J Med. 2006;355(7):739.

    Article  CAS  Google Scholar 

  30. Ramien ML, Wong A, Keystone JS. Severe refractory erythema nodosum leprosum successfully treated with the tumor necrosis factor inhibitor etanercept. Clin Infect Dis. 2011;52(5):e133–5.

    Article  CAS  Google Scholar 

  31. Lluch P, Urruticoechea A, Lluch J, Moll MC, Matos M, Benet JM, Ene L, Cañete JD. Development of leprosy in a patient with rheumatoid arthritis during treatment with etanercept: a case report. Semin Arthritis Rheum. 2012;42(2):127–30.

    Article  Google Scholar 

  32. Laurindo IM, Scheinberg M. Why do some biologic agents induce psoriasis or psoriasiform lesions. Nat Clin Pract Rheumatol. 2008;4:168–9.

    Article  CAS  Google Scholar 

  33. Zhang DF, Wang D, Li YY, Yao YG. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile. J Dermatol Sci. 2016;82(1):18–27.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Rheumatology Section, Medical School Universidade Federal do Amazonas, Manaus, AM, Brazil

    Sandra Lúcia Euzébio Ribeiro

  2. Center Hospital AACD, Rheumatologist Hospital Israelita Albert Einstein, and Advanced Center for Autoimmune Diseases Hospital BPMirante, Sao Paulo, SP, Brazil

    Ricardo Prado Golmia

  3. Fundação Alfredo da Mata, Manaus, AM, Brazil

    Lucilene Sales de Souza

  4. Department of Medicine, Universidade Nilton Lins, Manaus, AM, Brazil

    Gabriel Pacífico Seabra Nunes

  5. Rheumatology Section, Orthopedics Department, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil

    Morton Scheinberg

  6. Clinical Research Center Hospital AACD, Sao Paulo, SP, Brazil

    Morton Scheinberg

  7. Advanced Center for Autoimmune Diseases Hospital BPMirante, Sao Paulo, SP, Brazil

    Morton Scheinberg

Authors
  1. Sandra Lúcia Euzébio Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ricardo Prado Golmia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lucilene Sales de Souza
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriel Pacífico Seabra Nunes
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Morton Scheinberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. LSU Health Sciences at New Orleans, Louisiana State University, New Orleans, LA, USA

    Luis R. Espinoza

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ribeiro, S.L.E., Golmia, R.P., de Souza, L.S., Pacífico Seabra Nunes, G., Scheinberg, M. (2019). Leprosy-Associated Arthritis. In: Espinoza, L. (eds) Infections and the Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-23311-2_19

Download citation

Publish with us

Policies and ethics

Search

Navigation