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Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon

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The Golgi Apparatus and Centriole

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 67))

Abstract

The intracellular transport is the most confusing issue in the field of cell biology. The Golgi complex (GC) is the central station along the secretory pathway. It contains Golgi glycosylation enzymes, which are responsible for protein and lipid glycosylation, and in many cells, it is organized into a ribbon. Position and structure of the GC depend on the position and function of the centriole. Here, we analyze published data related to the role of centriole and intracellular transport (ICT) for the formation of Golgi ribbon and specifically stress the importance of the delivery of membranes containing cargo and membrane proteins to the cell centre where centriole/centrosome is localized. Additionally, we re-examined the formation of Golgi ribbon from the point of view of different models of ICT.

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Abbreviations

Apo B:

Apolipoprotein B

ArfGAP:

Arf GTPase activating protein

Bet3:

Trafficking protein particle complex subunit BET3

CMC:

Cis-most cisterna

CMPM:

Compartment (cisterna) maturation progression model

COP:

Coatomer

DM:

Diffusion model

EGC:

ER-Golgi carrier

EGT:

ER-Golgi transport

ER:

Endoplasmic reticulum

ERES:

ER exit site

GC:

Golgi complex

GFP:

Green fluorescent protein

GMAP210:

Golgi microtubule-associated protein 210 KDa

GTP:

Guanosine-5′-triphosphate

ICC:

Inter-cisternal connections

ICT:

Intracellular transport

IGT:

Intra-Golgi transport

KARM:

Kiss-and-run model

KIFC3:

Kinesin family member C3

Man:

Mannosidase

MT:

Microtubule

NSF:

N-ethylmaleimide-sensitive factor

PM:

Plasma membrane

Rab:

Ras-related in the brain

Sar1:

Secretion-associated RAS superfamily-related gene

Sec:

Secretory clone

SNAP:

Synaptosomal-associated protein

SNARE:

Soluble NSF attachment receptor

TGN:

Trans-Golgi network

TMC:

Trans-most cisterna

TRIP11:

Thyroid receptor-interacting protein 11

VLDL:

Very low-density lipoprotein

VM:

Vesicular model

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Authors and Affiliations

  1. The FIRC Institute of Molecular Oncology, Milan, Italy

    Alexander A. Mironov & Galina V. Beznoussenko

  2. Department of Anatomy, Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russia

    Ivan D. Dimov

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  1. Alexander A. Mironov
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  2. Ivan D. Dimov
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Correspondence to Alexander A. Mironov .

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  1. Department of Surgery, Houston Methodist Hospital, Houston, TX, USA

    Malgorzata Kloc

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Mironov, A.A., Dimov, I.D., Beznoussenko, G.V. (2019). Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon. In: Kloc, M. (eds) The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, vol 67. Springer, Cham. https://doi.org/10.1007/978-3-030-23173-6_4

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