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Hsp90: Is There an Unknown Role in Pain Neurobiology

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

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Abstract

Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that is essential in protein homeostasis and normal cell growth and survival, assisting protein folding, protein degradation and being highly recruited in cellular stress conditions. The implication of Hsp90 in several pathological conditions is being increasingly recognized, particularly in cancer, an area of intense research on the use of different Hsp90 inhibitors as a possible therapeutic approach, as well as on the associated mechanisms of action. There is also strong indication that the Hsp90 chaperone is involved in inflammation and neuroinflammation, and neurodegeneration events. Here we summarize some scientific evidence suggesting that Hsp90, and possibly its mitochondrial-compartimentalized homologue Tumour Necrosis Factor Receptor-Associated Protein 1 (TRAP-1), participate also in pain processing mechanisms.

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Abbreviations

17-AAG:

17-demethoxygeldanamycin

17-DMAG:

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

ATF3:

Activating transcription factor 3

CCI:

Chronic constriction injury

CGRP:

Calcitonin-gene-related peptide

CHIP:

Carboxyl terminus of Hsp70-interacting protein

CypD:

Cyclophilin D

DAMP:

Danger-associated molecular pattern

ERK:

Extracellular signal-regulated kinases

GFAP:

Glial fibrillary acidic protein

GHKL:

Gyrase, Hsp90, Histidine Kinase and MutL

HSE:

Heat shock element

HSF1:

Heat shock factor 1

HSP:

Heat shock proteins

Hsp70:

Heat shock protein 70

Hsp90:

Heat shock protein 90

IKK:

Inhibitor of κB (IκB) Kinase complex

IL-10:

Interleukin 10

IL-1β:

Interleukin 1 beta

IL-6:

Interleukin 6

IκB:

Inhibitor of κB

JAK2:

JAK/Signal Transducer and Activator of Transcription (STATs)

JNK:

c-Jun N-terminal kinase

MAPKs:

Mitogen-activated protein kinases

MOR:

Mu-opioid receptor

mPTP:

Mitochondrial permeability transition pore

NADPH:

Nicotinamide adenine dinucleotide phosphate

NF-κB:

Nuclear factor-kappa B

NO:

Nitric oxide

NOS:

NO synthases

NOX:

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases

PINK-1:

PTEN-induced Putative Kinase 1

PRRs:

Pattern recognition receptors

RIP:

Receptor interacting kinase

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

siRNA:

Small interference RNA

SP:

Substance P

STATs:

Signal transducer and activator of transcription

TAK-1/IKK:

TGF-β-activated kinase-1/Inhibitor of κB (IκB) Kinase complex

TLR2:

Toll-like-receptor 2

TLR4:

Toll like-receptor 4

TNFα:

Tumour necrosis factor alpha

TRAP-1:

Tumour necrosis factor receptor-associated protein 1

β-HIVS:

β-hydroxyisovalerylshikonin

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Authors and Affiliations

  1. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

    João Dias-Ferreira & Fani L. Moreira Neto

  2. IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

    João Dias-Ferreira & Fani L. Moreira Neto

  3. Departamento de Biomedicina – Unidade de Biologia Experimental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

    João Dias-Ferreira & Fani L. Moreira Neto

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  1. João Dias-Ferreira
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  2. Fani L. Moreira Neto
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Correspondence to Fani L. Moreira Neto .

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  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Dias-Ferreira, J., Moreira Neto, F.L. (2019). Hsp90: Is There an Unknown Role in Pain Neurobiology. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_25

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