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Heat Shock Protein 60 in Skin Diseases

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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Abstract

In addition to serving as a stress regulatory/response protein, heat shock protein 60 (Hsp60) also plays important roles in disease mechanism and progression. This chapter summarizes all aspects of the current knowledge on Hsp60 related to various skin diseases, including acne, atopic dermatitis (AD), dermatitis herpetiformis (DH), vasculitis, Behçet’s disease (BD), microscopic polyangiitis (MPA), systemic sclerosis (SSc), dermatomyositis, lichen planus (LP), and psoriasis. The data have shown that not only human Hsp60 but also its homologs in bacteria or microbes (e.g., GroEL) are involved in immune response and inflammatory cascade of these skin diseases. Furthermore, Hsp60 expression is also associated with severity of some diseases. Therefore, Hsp60 can be considered as a potential target for future development of a useful biomarker for diagnostics and prognostics in skin diseases. Moreover, it may also serve as a new therapeutic target for better treatment outcome.

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Abbreviations

AD:

atopic dermatitis

AECA:

anti-endothelial cell antibodies

ANCA:

anti-neutrophil cytoplasmic antibodies

BD:

Behçet’s disease

DH:

dermatitis herpetiformis

Hsp60:

heat shock protein 60

ICAM-1:

intercellular adhesion molecule-1

IFN-γ:

interferon-γ

IL:

interleukin

LP:

lichen planus

MPA:

microscopic polyangiitis

MPO:

myeloperoxidase

PBMC:

peripheral blood mononuclear cells

SLE:

systemic lupus erythematosus

SSc:

systemic sclerosis

TGF-β:

transforming growth factor-β

TLR:

toll-like receptors

TNF-α:

tumor necrosis factor-α

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Acknowledgements

This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Papapit Tuchinda

  2. Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Visith Thongboonkerd

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  1. Papapit Tuchinda
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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Tuchinda, P., Thongboonkerd, V. (2019). Heat Shock Protein 60 in Skin Diseases. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_21

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