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Hsp60 Involvement During Carcinogenesis

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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Abstract

The implication of Hsp60 in cancer development is due to its participation in many metabolic and biomolecular mechanisms in cancer cells. Hsp60 interacts with various molecules that are responsible of apoptosis, cell proliferation and other mechanisms involved when a normal cell becomes malignant. Hsp60 expression was found to be increased in many types of cancer but in same tumors of different anatomical district was found decreased. The mechanism of action of Hsp60 is different depending on the type of tumor. Its involvement in the carcinogenetic process of some tumors, such as large bowel carcinoma or cervical carcinoma, seems to occur in the very early stages of disease. Hsp60 participates in the mechanism of modulation of the immune response the cancer cells use to invade surrounding tissues, and expand the tumor mass.

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Abbreviations

APCs:

Antigen-presenting cells

Bax:

Bcl-2-associated X protein

CD:

Cluster of differentiation

c-myc:

Cancer myelocytomatosis

COPD:

Chronic obstructive pulmonary disease

DCs:

Dendritic cells

G1:

Grading 1

G2:

Grading 2

G3:

Grading 3

Hsp:

Heat shock protein

IAP:

Inhibitors of apoptosis protein

IFNγ:

Interferon gamma

IKK:

IκB kinase

IL:

Interleukin

KA:

Keratoacantomas

MMP9:

Matrix metallopeptidase 9

mtHsp:

Mithocondrial Heat shock protein

MyD88:

Myeloid differentiation primary response 88

NCI-H292:

Human lung mucoepidermoid cell

NF-kB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NK:

Natural killer

pC3:

Pro-caspase-3

PIN:

Prostatic intraepithelial lesions

ROS:

Reactive oxygen species

SCC:

Squamous cell carcinomas

SIL:

Squamous intraepithelial lesion

Th1:

Type 1 T helper

TLR:

Toll-like receptor

VEGF:

Vascular endothelial growth factor

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Acknowledgements

F.C. and F.R. were partially supported by UniPA.

Author information

Authors and Affiliations

  1. Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, Palermo, Italy

    Francesca Rappa & Francesco Carini

  2. Department of Anatomy, Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, Msida, Malta

    Pierre Schembri Wismayer

Authors
  1. Francesca Rappa
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  2. Francesco Carini
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  3. Pierre Schembri Wismayer
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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Rappa, F., Carini, F., Schembri Wismayer, P. (2019). Hsp60 Involvement During Carcinogenesis. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_10

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