Skip to main content
SpringerLink
Log in

Rheumatoid Arthritis

  • Chapter
  • First Online:
Absolute Rheumatology Review

  • 1493 Accesses

Abstract

Rheumatoid arthritis (RA) is the most common autoimmune rheumatologic condition classically presenting as symmetric polyarthritis. Smoking and microbiome are implicated in its pathogenesis in the background of a genetically susceptible host. RA is a systemic disease beyond joint involvement with pulmonary, cardiac, vascular, cutaneous, hematologic, and ophthalmologic manifestations especially in patients who are seropositive. Early diagnosis and treatment targeting low disease activity has yielded improved outcomes. RA confers increased cardiovascular risk independent of traditional factors and requires multidisciplinary management. Biomarkers of response to allow for patient-tailored treatment are needed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kim K, Bang SY, Lee HS, Bae SC. Update on the genetic architecture of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(1):13–24.

    Article  CAS  Google Scholar 

  2. Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol. 1993;32(10):903–7.

    Article  CAS  Google Scholar 

  3. van Drongelen V, Holoshitz J. Human leukocyte antigen-disease associations in rheumatoid arthritis. Rheum Dis Clin N Am. 2017;43(3):363–76.

    Article  Google Scholar 

  4. Yamada R, Yamamoto K. Mechanisms of disease: genetics of rheumatoid arthritis – ethnic differences in disease-associated genes. Nat Clin Pract Rheumatol. 2007;3(11):644–50.

    Article  CAS  Google Scholar 

  5. Linn-Rasker SP, van der Helm-van Mil AH, van Gaalen FA, Kloppenburg M, de Vries RR, le Cessie S, et al. Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis. 2006;65(3):366–71.

    Article  CAS  Google Scholar 

  6. Okada M, Kobayashi T, Ito S, Yokoyama T, Abe A, Murasawa A, et al. Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis. J Periodontol. 2013;84(12):e74–84.

    Article  CAS  Google Scholar 

  7. Gierut A, Perlman H, Pope RM. Innate immunity and rheumatoid arthritis. Rheum Dis Clin N Am. 2010;36(2):271–96.

    Article  Google Scholar 

  8. Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, et al. Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med. 2004;200(12):1673–9.

    Article  CAS  Google Scholar 

  9. Huber LC, Distler O, Tarner I, Gay RE, Gay S, Pap T. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford). 2006;45(6):669–75.

    Article  CAS  Google Scholar 

  10. O’Shea JJ, Gadina M. Selective Janus kinase inhibitors come of age. Nat Rev Rheumatol. 2019;15:74.

    Article  Google Scholar 

  11. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69(9):1580–8.

    Article  Google Scholar 

  12. Kim HJ, Nemani VM, Riew KD, Brasington R. Cervical spine disease in rheumatoid arthritis: incidence, manifestations, and therapy. Curr Rheumatol Rep. 2015;17(2):9.

    Article  Google Scholar 

  13. Sanmarti R, Cabrera-Villalba S, Gomez-Puerta JA, Ruiz-Esquide V, Hernandez MV, Salvador G, et al. Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. J Rheumatol. 2012;39(10):1929–33.

    Article  Google Scholar 

  14. Liu X, Loughran TP Jr. The spectrum of large granular lymphocyte leukemia and Felty’s syndrome. Curr Opin Hematol. 2011;18(4):254–9.

    Article  CAS  Google Scholar 

  15. Baillet A, Gaujoux-Viala C, Mouterde G, Pham T, Tebib J, Saraux A, et al. Comparison of the efficacy of sonography, magnetic resonance imaging and conventional radiography for the detection of bone erosions in rheumatoid arthritis patients: a systematic review and meta-analysis. Rheumatology (Oxford). 2011;50(6):1137–47.

    Article  Google Scholar 

  16. Porter D. Intensive management of early rheumatoid arthritis: the TICORA and TEAR studies. Clin Exp Rheumatol. 2012;30(4 Suppl 73):S32–4.

    PubMed  Google Scholar 

  17. Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012;64(5):625–39.

    Article  CAS  Google Scholar 

  18. O’Dell JR, Mikuls TR, Taylor TH, Ahluwalia V, Brophy M, Warren SR, et al. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013;369(4):307–18.

    Article  Google Scholar 

  19. van Vollenhoven RF, Geborek P, Forslind K, Albertsson K, Ernestam S, Petersson IF, et al. Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial. Lancet. 2012;379(9827):1712–20.

    Article  Google Scholar 

  20. Porter D, van Melckebeke J, Dale J, Messow CM, McConnachie A, Walker A, et al. Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial. Lancet. 2016;388(10041):239–47.

    Article  CAS  Google Scholar 

  21. Firestein GS, Gabriel SE, McInnes IB, O’Dell JR. Kelley & Firestein’s textbook of rheumatology. 10th ed. Philadelphia: Elsevier; 2017. 2 volumes (xxx, 2086, p. I70).

    Google Scholar 

  22. Vieira MC, Zwillich SH, Jansen JP, Smiechowski B, Spurden D, Wallenstein GV. Tofacitinib versus biologic treatments in patients with active rheumatoid arthritis who have had an inadequate response to tumor necrosis factor inhibitors: results from a network meta-analysis. Clin Ther. 2016;38(12):2628–41.e5.

    Article  CAS  Google Scholar 

  23. Urman A, Taklalsingh N, Sorrento C, McFarlane IM. Inflammation beyond the joints: rheumatoid arthritis and cardiovascular disease. Scifed J Cardiol. 2018;2(3):1000019.

    PubMed  PubMed Central  Google Scholar 

  24. Wilton KM, Matteson EL. Malignancy incidence, management, and prevention in patients with rheumatoid arthritis. Rheumatol Ther. 2017;4(2):333–47.

    Article  Google Scholar 

  25. Wolfe F, Michaud K. The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study. Arthritis Res Ther. 2010;12(2):R35.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology Allergy and Immunology, Stony Brook University Hospital, Stony Brook, NY, USA

    Saleha Riaz & Apostolos Kontzias

Authors
  1. Saleha Riaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Apostolos Kontzias
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Apostolos Kontzias .

Editor information

Editors and Affiliations

  1. New York University, New York, NY, USA

    Petros Efthimiou

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Riaz, S., Kontzias, A. (2020). Rheumatoid Arthritis. In: Efthimiou, P. (eds) Absolute Rheumatology Review. Springer, Cham. https://doi.org/10.1007/978-3-030-23022-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-23022-7_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23021-0

  • Online ISBN: 978-3-030-23022-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation