Abstract
Nutritional epigenetics is a sub-discipline of nutrigenomics and describes how dietary compounds affect our epigenome. Chromatin modifiers use intermediary metabolites, such as acetyl-CoA, α-ketoglutarate, NAD+, FAD, ATP or SAM, as co-substrates and/or co-factors. In this way, chromatin modifiers act as sensors for the nutritional status of our tissues and cell types leaving respective marks on their epigenome. The thrifty phenotype is a concept of epigenetic programing of metabolic tissues during pre-natal development. Its principles apply also in adult life and may explain the missing heritability of the susceptibility for complex metabolic diseases, such as type 2 diabetes.
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Carlberg, C., Molnár, F. (2019). Nutritional Epigenetics. In: Human Epigenetics: How Science Works. Springer, Cham. https://doi.org/10.1007/978-3-030-22907-8_10
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DOI: https://doi.org/10.1007/978-3-030-22907-8_10
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