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Pancreatic Neuroendocrine Tumors and Other Solid Tumors of Pancreas

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Pancreas and Biliary Tract Cytohistology

Part of the book series: Essentials in Cytopathology ((EICP,volume 28))

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Abstract

This chapter reviews the key features that define pancreatic neuroendocrine neoplasia, acinar cell carcinoma, solid pseudopapillary neoplasm, and pancreatoblastoma on cytology specimens. These four tumors often share overlapping clinical and morphologic features and consequently must often be considered together within the same differential diagnosis. This large amount of potential morphologic overlap requires the use of ancillary immunohistochemical studies in most cases in order to arrive at accurate diagnoses. The ability to effectively diagnose these entities is critical as each diagnosis portends dramatically different prognoses and treatment. This chapter will review the key clinical, cytomorphologic, and immunohistochemical features required to effectively work through this challenging differential diagnosis.

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References

  1. Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors of the digestive system. Lyon: IARC; 2010.

    Google Scholar 

  2. Sigel CS. Advances in the cytologic diagnosis of gastroenteropancreatic. Cancer Cytopathol. 2018. Epub ahead of print. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/cncy.22073.

  3. Chhieng DC, Stelow EB. Pancreatic cytopathology. New York: Springer; 2007.

    Book  Google Scholar 

  4. Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders/Elsevier; 2015.

    Google Scholar 

  5. Bellizzi AM, Stelow EB. Pancreatic cytopathology: a practical approach and review. Arch Pathol Lab Med. 2009;133(3):388–404.

    PubMed  Google Scholar 

  6. Shah S, Mortele KJ. Uncommon solid pancreatic neoplasms: ultrasound, computed tomography, and magnetic resonance imaging features. Semin Ultrasound CT MR. 2007;28(5):357–70.

    Article  Google Scholar 

  7. Milan SA, Yeo CJ. Neuroendocrine tumors of the pancreas. Curr Opin Oncol. 2012;24(1):46–55.

    Article  Google Scholar 

  8. Jahan A, Yusuf MA, Loya A. Fine-needle aspiration cytology in the diagnosis of pancreatic neuroendocrine tumors: a single-center experience of 25 cases. Acta Cytol. 2015;48(3):163–8.

    Article  Google Scholar 

  9. Inzani F, Petrone G, Rindi G. The New World Health Organization classification for pancreatic neuroendocrine neoplasia. Endocrinol Metab Clin N Am. 2018;47(3):463–70.

    Article  Google Scholar 

  10. Jiménez-Heffernan JA, Vicandi B, López-Ferrer P, González-Peramato P, Pérez-Campos A, Viguer JM. Fine needle aspiration cytology of endocrine neoplasms of the pancreas. Morphologic and immunocytochemical findings in 20 cases. Acta Cytol. 2004;48(3):295–301.

    Article  Google Scholar 

  11. Gu M, Ghafari S, Lin F, Ramzy I. Cytological diagnosis of endocrine tumors of the pancreas by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagn Cytopathol. 2005;32(4):204–10.

    Article  Google Scholar 

  12. Labate AM, Klimstra DL, Zakowski MF. Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. Diagn Cytopathol. 1997;16(2):112–6.

    Article  CAS  Google Scholar 

  13. Paschalis C, Charitini S, Panagiotis K, Ioannis K, Stratigoula S, Irini D. Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumors: a study of 48 cases. Cancer Cytopathol. 2008;114(4):255–62.

    Article  Google Scholar 

  14. Wood LD, Klimstra DS. Pathology and genetics of pancreatic neoplasms with acinar differentiation. Semin Diagn Pathol. 2014;31(6):491–7.

    Article  Google Scholar 

  15. La Rosa S, Adsay V, Albarello L, Asioli S, Casnedi S, Franzi F, et al. Clinicopathologic study of 62 acinar cell carcinomas of the pancreas: insights into the morphology and immunophenotype and search for prognostic markers. Am J Surg Pathol. 2012;36(12):1782–95.

    Article  Google Scholar 

  16. Serra S, Chetty R. Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas. J Clin Pathol. 2008;61(11):1153–9.

    Article  CAS  Google Scholar 

  17. La Rosa S, Sessa F, Capella C. Acinar cell carcinoma of the pancreas: overview of clinicopathologic features and insights into the molecular pathology. Front Med (Lausanne). 2015;2(41). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469112/.

  18. Simmons S, Eltoum IA. Acinar cell carcinoma of the pancreas: cytologic, immunohistochemical, and ultrastructural features. Pathol Case Rev. 2015;20(4):192–5.

    Article  Google Scholar 

  19. Stelow EB, Bardales RH, Shami VM, Woon C, Presley A, Mallery S, et al. Cytology of pancreatic acinar cell carcinoma. Diagn Cytopathol. 2006;34(4):367–72.

    Article  Google Scholar 

  20. Das S, Ghosh R, Sen A, Das RN, Saha K, Chatterjee U. Fine needle aspiration cytology diagnosis of a pancreatoblastoma in an infant: case report with a summary of prior published cases. Cytopathology. 2016;27(6):479–82.

    Article  CAS  Google Scholar 

  21. Klimstra DS, Wenig BM, Adair CF, Heffess CS. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol. 1995;19(12):1371–89.

    Article  CAS  Google Scholar 

  22. Sidhu GS, Cassai ND, Yang GCH. Fine-needle aspiration cytology of pancreatoblastoma in a young woman: report of a case and review of the literature. Diagn Cytopathol. 2005;33(4):258–62.

    Article  Google Scholar 

  23. Henke AC, Kelley CM, Jensen CS, Timmerman TG. Fine-needle aspiration cytology of pancreatoblastoma. Diagn Cytopathol. 2001;25(2):118–21.

    Article  CAS  Google Scholar 

  24. Pitman MB, Faquin WC. The fine-needle aspiration biopsy cytology of pancreatoblastoma. Diagn Cytopathol. 2004;31(6):402–6.

    Article  Google Scholar 

  25. Huang HL, Shih SC, Chang WH, Wang TE, Chen MJ, Chan YJ. Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review. World J Gastroenterol. 2005;11(9):1403–9.

    Article  Google Scholar 

  26. Ersen A, Agalar AA, Ozer E, Agalar C, Unek T, Egeli T, et al. Solid-Pseudopapillary neoplasm of the pancreas: a clinicopathological review of 20 cases including rare examples. Pathol Res Pract. 2016;212(11):1052–8.

    Article  Google Scholar 

  27. Salvia R, Bassi C, Festa L, Falconi M, Crippa S, Butturini G, et al. Clinical and biological behavior of pancreatic solid pseudopapillary tumors: report on 31 consecutive patients. J Surg Oncol. 2007;95(4):304–10.

    Article  Google Scholar 

  28. Vassos N, Agaimy A, Klein P, Hohenberger W, Croner RS. Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity. Int J Clin Exp Pathol. 2013;6(6):1051–9.

    PubMed  PubMed Central  Google Scholar 

  29. Bardales RH, Centeno B, Mallery JS, Lai R, Pochapin M, Guiter G, Stanley MW. Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas: a rare neoplasm of elusive origin but characteristic cytomorphologic features. Am J Clin Pathol. 2004;121(5):654–62.

    Article  Google Scholar 

  30. Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200(6):965–72.

    Article  Google Scholar 

  31. Klimstra DS, Adsay V. Acinar neoplasms of the pancreas-A summary of 25 years. Semin Diagn Pathol. 2016;33(5):307–18.

    Article  Google Scholar 

  32. Lin F, Chen ZE, Wang HL. Utility of immunohistochemistry in the pancreaticobiliary tract. Arch Pathol Lab Med. 2015;139(1):24–38.

    Article  Google Scholar 

  33. Ohara Y, Oda T, Hashimoto S, Akashi Y, Miyamoto R, Enomoto T, Satomi K. Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: key immunohistochemical profiles for differential diagnosis. World J Gastroenterol. 2016;22(38):8596–604.

    Article  CAS  Google Scholar 

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Correspondence to Jacob Sweeney .

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Sweeney, J., Rao, R. (2019). Pancreatic Neuroendocrine Tumors and Other Solid Tumors of Pancreas. In: Goyal, A., Rao, R., Siddiqui, M. (eds) Pancreas and Biliary Tract Cytohistology. Essentials in Cytopathology, vol 28. Springer, Cham. https://doi.org/10.1007/978-3-030-22433-2_6

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  • DOI: https://doi.org/10.1007/978-3-030-22433-2_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22432-5

  • Online ISBN: 978-3-030-22433-2

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