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Clinical Presentation and Diagnosis

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Intrahepatic Cholangiocarcinoma

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor after hepatocellular carcinoma. In recent years, there has been an increasing trend in the incidence and mortality rate of ICC worldwide. In general, the outcome of patients with ICC is dismal, mainly due to late diagnosis and lack of effective treatment options. Detection of the tumor at early stages may make surgical resection, as the only potentially curative treatment, more feasible. Identifying ICC-specific diagnostic and prognostic biomarkers has been a focus of interest among many investigators. Unfortunately, despite recent developments in imaging modalities and laboratory tests, the diagnosis of ICC remains challenging and the majority of patients are not amenable to surgical resection at the time of presentation. Herein, we provide an overview of the current modalities used in the diagnosis of ICC.

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Author information

Authors and Affiliations

  1. Department of Surgery, University of Washington Medical Center, Seattle, WA, USA

    Arezou Abbasi

  2. Department of Surgery, Division of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Amir A. Rahnemai-Azar, Sean M. Ronnekleiv-Kelly, Daniel E. Abbott & Sharon M. Weber

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  1. Arezou Abbasi
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  2. Amir A. Rahnemai-Azar
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  3. Sean M. Ronnekleiv-Kelly
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  4. Daniel E. Abbott
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  5. Sharon M. Weber
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Corresponding author

Correspondence to Sharon M. Weber .

Editor information

Editors and Affiliations

  1. Wexner Medical Center, The Ohio State University, Columbus, OH, USA

    Timothy M. Pawlik

  2. Wexner Medical Center, The Ohio State University, Columbus, OH, USA

    Jordan M. Cloyd

  3. Wexner Medical Center, The Ohio State University, Columbus, OH, USA

    Mary Dillhoff

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Abbasi, A., Rahnemai-Azar, A.A., Ronnekleiv-Kelly, S.M., Abbott, D.E., Weber, S.M. (2019). Clinical Presentation and Diagnosis. In: Pawlik, T., Cloyd, J., Dillhoff, M. (eds) Intrahepatic Cholangiocarcinoma. Springer, Cham. https://doi.org/10.1007/978-3-030-22258-1_2

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  • DOI: https://doi.org/10.1007/978-3-030-22258-1_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22257-4

  • Online ISBN: 978-3-030-22258-1

  • eBook Packages: MedicineMedicine (R0)

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