Abstract
This chapter deals with the study of absorption, distribution, metabolism/biotransformation, and excretion (ADME) of xenobiotics and the study of toxicokinetics of toxicants/xenobiotics in relation to time in animals. Toxicokinetics represents behavior of drugs in the system and extension of kinetic principles to the study of toxicology including applications ranging from the study of adverse drug effects to investigations on how disposition kinetics of exogenous chemicals are derived from either natural or environmental sources that govern their deleterious effects on animals and human beings.
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Further Reading
Beasley V (1999) Absorption, distribution, metabolism, and elimination: differences among species. In: Beasley V (ed) Veterinary toxicology. International Veterinary Information Service (www.ivis.org), Ithaca https://www.researchgate.net/publication/268347521_Absorption_Distribution_Metabolism_and_Elimination_Differences_Among_Species_9-Aug-1999
Gupta PK (2010) Absorption, distribution, & excretion of xenobiotics. In: Gupta PK (ed) Modern toxicology: basis of organ and reproduction toxicity, vol 1, second reprint. PharmaMed Press, Hyderabad, pp 71–92
Gupta PK (2016) Fundamental of toxicology: essential concept and applications. Elsevier/BSP, San Diego. (Chapters 8 and 9)
Gupta PK (2018) Illustrative toxicology, 1st edn. Elsevier, San Diego
Lehman-McKeeman LD (2013) Absorption distribution and excretion of toxicants. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn, McGraw-Hill, pp 153–184
Patkinson A, Ogilvie BW (2013) Biotransformation of xenobiotics. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn. McGraw-Hill, New York, pp 185–366
Shen DD (2013) Toxicokinetics. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 8th edn. McGraw-Hill, New York, pp 367–390
Timbrell JA (2009) Factors affecting toxic responses: disposition. In: Timbrell JA (ed) Principles of biochemical toxicology, 4th edn, Informa, New York, pp 35–74
Van der Merwe D, Gehring R, Buur JL (2018) Toxicokinetics in veterinary toxicology. In: Gupta RC (ed) Veterinary toxicology: basic and clinical principles, 3rd edn. Academic Press/Elsevier, Amsterdam, pp 133–144
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Gupta, P. (2019). Disposition and Fate of Toxicants. In: Concepts and Applications in Veterinary Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-22250-5_2
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DOI: https://doi.org/10.1007/978-3-030-22250-5_2
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