Abstract
Low back pain is one of the most common musculoskeletal conditions and among the top causes of disability worldwide. Low back pain can be associated with a specific pathology such as spinal stenosis, herniated disc, or spondylolisthesis; however, most cases of low back pain do not have an identifiable mechanical source or structural deformity. Characterizing the location, affective and sensory dimensions, intensity and interference of pain is crucial for precise phenotyping and investigation of underlying mechanisms. The following chapter will review methods of phenotyping low back pain and the integration of multi-omic based measures to study the transition from acute to chronic pain, which is relevant for other types of musculoskeletal pain, and discuss major findings in the field.
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Starkweather, A.R., Dorsey, S.G. (2020). Low Back Pain. In: Dorsey, S., Starkweather, A. (eds) Genomics of Pain and Co-Morbid Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-21657-3_7
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