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Bayesian Clustering for HIV1 Protease Inhibitor Contact Maps

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Artificial Intelligence in Medicine (AIME 2019)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 11526))

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Abstract

We present a probabilistic model for clustering which enables the modeling of overlapping clusters where objects are only available as pairwise distances. Examples of such distance data are genomic string alignments, or protein contact maps. In our clustering model, an object has the freedom to belong to one or more clusters at the same time. By using an IBP process prior, there is no need to explicitly fix the number of clusters, as well as the number of overlapping clusters, in advance. In this paper, we demonstrate the utility of our model using distance data obtained from HIV1 protease inhibitor contact maps.

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References

  1. Achenbach, C.J., Darin, K.M., Murphy, R.L., Christine, K.: Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults. Future Virol. 6(2), 157–177 (2011)

    Article  Google Scholar 

  2. Berman, H.M., et al.: The protein data bank. Nucleic Acids Res. 28, 235–242 (2000)

    Article  Google Scholar 

  3. Bernardino, J.I., Arribas, J.R.: Antiviral therapy. Infect. Dis. 4, 918–926 (2011)

    Google Scholar 

  4. Griffiths, T.L., Ghahramani, Z.: Infinite latent feature models and the Indian buffet process, May 2005

    Google Scholar 

  5. Heller, K.A., Ghaharamani, Z.: A nonparametric Bayesian approach to modeling overlapping clusters. In: AISTATS (2007)

    Google Scholar 

  6. Li, M., Vitányi, P.: An Introduction to Kolmogorov Complexity and Its Applications. Texts in Computer Science. Springer, New York (2008). https://doi.org/10.1007/978-0-387-49820-1

    Book  MATH  Google Scholar 

  7. Zhengtong, L., Chu, Y., Wang, Y.: HIV protease inhibitors: a review of molecular selectivity and toxicity. HIV AIDS (Auckl.) 7, 95 (2015)

    Google Scholar 

  8. Schölkopf, B., Smola, A.J., et al.: Learning with kernels: support vector machines, regularization, optimization, and beyond (2002)

    Google Scholar 

  9. Streich, A.P., Frank, M., Buhmann, J.M.: Multi-assignment clustering for Boolean data. In: ICML (2009)

    Google Scholar 

  10. Vitányi, P.M.B., Balbach, F.J., Cilibrasi, R.L., Li, M.: Normalized information distance. In: Emmert-Streib, F., Dehmer, M. (eds.) Information Theory and Statistical Learning, pp. 45–82. Springer, Boston (2009). https://doi.org/10.1007/978-0-387-84816-7_3

    Chapter  MATH  Google Scholar 

  11. Vogt, J.E., Prabhakaran, S., Fuchs, T.J., Roth, V.: The translation-invariant Wishart-Dirichlet process for clustering distance data. In: ICML, pp. 1111–1118 (2010)

    Google Scholar 

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Correspondence to Sandhya Prabhakaran .

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Prabhakaran, S., Vogt, J.E. (2019). Bayesian Clustering for HIV1 Protease Inhibitor Contact Maps. In: Riaño, D., Wilk, S., ten Teije, A. (eds) Artificial Intelligence in Medicine. AIME 2019. Lecture Notes in Computer Science(), vol 11526. Springer, Cham. https://doi.org/10.1007/978-3-030-21642-9_35

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  • DOI: https://doi.org/10.1007/978-3-030-21642-9_35

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21641-2

  • Online ISBN: 978-3-030-21642-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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