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All Around the Nose pp 303–310Cite as

Hypersensitivity to Aspirin and Other Non-steroidal Anti-inflammatory Drugs

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Abstract

Non-steroidal anti-inflammatory drug (NSAIDs) are documented as causing the second highest number of medication-related hypersenstivity reactions and as the third highest reason for allergy consulations. The prevalence of hypersentivity to NSAIDs in the general population at large between 0.5 and 2.5%. Estimation of prevalence depends, however, on diagnostic methodology and patient characteristics, such as gender, age and the presence of comorbidity such as asthma, persistent rhinosinusitis, nasal polyps and chronic hives. Being asthmatics carries a 10-20% risk, whilst being asthmatic and having nasal polyposis carries a 30-40% risk of having NSAID-hypersensitivity. Children are less frequently affected than adults; and there is a female predilection. Classification of NSAID-hypersensitivity are based on clinical picture, whether an underlying pathology is present, and extent to which cross-reaction occurs with other members of the COX-1 inhibitor group. NSAID-exacerbated respiratory disease (NERD) refers to the combination of asthma, chronic rhinosinusitis with nasal polyposis, and acute upper and lower respiratory tract reactions to the ingestion of NSAID. Disscussion in this chapter is confined to NERD.

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Author information

Authors and Affiliations

  1. Division of Immunology and Allergic Diseases, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey

    Adile Berna Dursun

  2. Department of Otorhinolaryngology, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey

    Engin Dursun

  3. Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA, USA

    D. Donald Stevenson

Authors
  1. Adile Berna Dursun
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  2. Engin Dursun
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  3. D. Donald Stevenson
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Editor information

Editors and Affiliations

  1. Eskişehir Osmangazi University, Medical Faculty, Department of Otorhinolaryngology, Eskisehir, Turkey

    Cemal Cingi

  2. Department of Otorhinolaryngology, Medical Faculty, Kirikkale University, Kirikkale, Turkey

    Nuray Bayar Muluk

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Dursun, A.B., Dursun, E., Stevenson, D.D. (2020). Hypersensitivity to Aspirin and Other Non-steroidal Anti-inflammatory Drugs. In: Cingi, C., Bayar Muluk, N. (eds) All Around the Nose. Springer, Cham. https://doi.org/10.1007/978-3-030-21217-9_34

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  • DOI: https://doi.org/10.1007/978-3-030-21217-9_34

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  • Online ISBN: 978-3-030-21217-9

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