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Cooling Techniques and Ex Situ Liver Surgery

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Liver Transplantation and Hepatobiliary Surgery

Part of the book series: Updates in Surgery ((UPDATESSURG))

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Abstract

Hypothermic preservation is a strategy to reduce ischemia-reperfusion injury in both liver transplantation and liver resection procedures and has been successfully used in liver transplantation setting since the early 1960s to prolong the viability of harvested liver grafts. Static cold storage is able to reduce cellular metabolism by 10- to 12-fold and to slow down energy demand. Hypothermic perfusion is used also during complex liver resection in order to protect the liver parenchyma from ischemia-reperfusion injury during total vascular exclusion.

Ex situ liver resection is a complex kind of surgery burdened by a high morbidity and mortality rate and feasible only for a strictly selected category of patients affected by primary and metastatic liver cancer considered unresectable by conventional surgery. Surgical expertise in liver transplant is required due to the several similarities with the transplant techniques.

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Authors and Affiliations

  1. Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy

    Umberto Cillo & Enrico Gringeri

  2. Hepatobiliary Surgery and Liver Transplant Unit, Padua University Hospital, Padua, Italy

    Umberto Cillo & Enrico Gringeri

Authors
  1. Umberto Cillo
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  2. Enrico Gringeri
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Corresponding author

Correspondence to Umberto Cillo .

Editor information

Editors and Affiliations

  1. Department of Surgery, Oncology and Gastroenterology, University of Padua, Hepatobiliary Surgery and Liver Transplant Unit, Padua University Hospital, Padua, Italy

    Umberto Cillo

  2. Department of General Surgery and Transplantation, Niguarda Hospital, School of Medicine and Surgery University of Milano-Bicocca, Milan, Italy

    Luciano De Carlis

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Cillo, U., Gringeri, E. (2020). Cooling Techniques and Ex Situ Liver Surgery. In: Cillo, U., De Carlis, L. (eds) Liver Transplantation and Hepatobiliary Surgery. Updates in Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19762-9_4

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  • DOI: https://doi.org/10.1007/978-3-030-19762-9_4

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-19761-2

  • Online ISBN: 978-3-030-19762-9

  • eBook Packages: MedicineMedicine (R0)

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