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Cardiovascular Hemodynamics pp 73–88Cite as

Beta Blockers and Calcium Channel Blockers

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Calcium channel blockers and beta blockers are medicines commonly prescribed for the treatment of hypertension and tachyarrhythmias. Beta blockers prevent stimulation of the beta-adrenergic receptors at the nerve endings of the sympathetic nervous system and therefore reduce systolic pressure, heart rate, and cardiac contractility and output. Calcium channel blockers block voltage-gated calcium channels and inhibit the influx of calcium ions into cardiac and smooth muscle cells. The decrease in intracellular calcium inhibits cardiac contraction, but promotes vasodilatation. Beta blockers are likely overprescribed; they are ineffective antihypertensive agents. Current evidence supports their use in patients with systolic heart failure and for rate control.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital Bern, Bern, Switzerland

    Alexandra-Maria Neagoe & Emrush Rexhaj

  2. Department for Biomedical Research, University of Bern, Bern, Switzerland

    Emrush Rexhaj

  3. The Chaim Sheba Medical Center, The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

    Ehud Grossman

  4. Department of Cardiology, University of Bern, Bern, Switzerland

    Franz H. Messerli

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  1. Alexandra-Maria Neagoe
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  2. Emrush Rexhaj
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  3. Ehud Grossman
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  4. Franz H. Messerli
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Editors and Affiliations

  1. Premier Health Advocates, Beachwood, OH, USA

    Arman T. Askari

  2. Gill Heart and Vascular Institute, University of Kentucky HealthCare, Lexington, KY, USA

    Adrian W. Messerli

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Neagoe, AM., Rexhaj, E., Grossman, E., Messerli, F.H. (2019). Beta Blockers and Calcium Channel Blockers. In: Askari, A., Messerli, A. (eds) Cardiovascular Hemodynamics. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-030-19131-3_6

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