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Neural Synchronization in Parkinson’s Disease on Different Time Scales

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Multiscale Models of Brain Disorders

Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 13))

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Abstract

Parkinson’s disease is marked by an elevated neural synchrony in the cortico-basal ganglia circuits in the beta frequency band. This elevated synchrony has been associated with Parkinsonian hypokinetic symptoms. The application of recently developed synchronization analysis techniques allows us to investigate the temporal dynamics of synchrony on different time scales. The results of this analysis are summarized here, revealing highly variable dynamics of synchronized neural activity on multiple time scales and its association with disease.

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Acknowledgments

This paper was supported by the ICTSI/Indiana University Health–IU School of Medicine Strategic Research Initiative, the National Science Foundation Grant DMS 1813819, and National Science Foundation Grant HRD 1700199.

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Authors and Affiliations

  1. Department of Mathematics, East Carolina University, Greenville, NC, USA

    Sungwoo Ahn

  2. Department of Mathematics, North Carolina A&T State University, Greensboro, NC, USA

    Choongseok Park

  3. Department of Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

    Leonid L. Rubchinsky

  4. Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA

    Leonid L. Rubchinsky

Authors
  1. Sungwoo Ahn
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  2. Choongseok Park
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  3. Leonid L. Rubchinsky
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Corresponding author

Correspondence to Sungwoo Ahn .

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Editors and Affiliations

  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Ahn, S., Park, C., Rubchinsky, L.L. (2019). Neural Synchronization in Parkinson’s Disease on Different Time Scales. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_6

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