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Brain Connectivity Reduction Reflects Disturbed Self-Organisation of the Brain: Neural Disorders and General Anaesthesia

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Multiscale Models of Brain Disorders

Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 13))

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Abstract

The neurophysiological correlate of functional neural impairment is an open problem. Functional impairment may be observed as mental disorder, seizures or modification of consciousness level. The latter include loss of responsiveness under general anaesthesia, sleep or even trance in hypnosis. This chapter points out the relation between reduced brain connectivity as a possible correlate of neural functional impairment and self-organisation in the brain. A first numerical example demonstrates how neural noise disturbs self-organisation in the brain. Estimators of self-organisation such as global phase synchrony or information transfer quantify the degree of self-organisation. The chapter provides a brief literature review on how these estimators indicate brain connectivity modifications in neural disorders and under general anaesthesia.

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Authors and Affiliations

  1. Department FE 12 (Data Assimilation), Deutscher Wetterdienst – German Meteorological Service, Research and Development, Offenbach am Main, Germany

    Axel Hutt

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  1. Axel Hutt
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  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Hutt, A. (2019). Brain Connectivity Reduction Reflects Disturbed Self-Organisation of the Brain: Neural Disorders and General Anaesthesia. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_19

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