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Simulating Cognitive Deficits in Parkinson’s Disease

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Multiscale Models of Brain Disorders

Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 13))

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Abstract

Parkinson’s disease (PD) is caused by the accelerated death of dopamine–producing neurons. Numerous studies documenting cognitive deficits of people with PD have revealed impairment in a variety of tasks related to memory, learning, visuospatial skills, and attention. In this chapter, we describe a general approach used to model PD and review three computational models that have been used to simulate cognitive deficits related to PD. The models presentation is followed by a discussion of the role of glia cells and astrocytes in neurodegenerative diseases. We propose that more biologically–realistic computational models of neurodegenerative diseases that include astrocytes may lead to a better understanding and treatment of neurodegenerative diseases in general and PD in particular.

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Acknowledgements

This research was funded in part by the National Institute of Mental Health, award #2R01MH063760.

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Authors and Affiliations

  1. Department of Psychological Science, Purdue University, West Lafayette, IN, USA

    Sébastien Hélie & Zahra Sajedinia

Authors
  1. Sébastien Hélie
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  2. Zahra Sajedinia
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Correspondence to Sébastien Hélie .

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Editors and Affiliations

  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Hélie, S., Sajedinia, Z. (2019). Simulating Cognitive Deficits in Parkinson’s Disease. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_10

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