Abstract
Parkinson’s disease (PD) is caused by the accelerated death of dopamine–producing neurons. Numerous studies documenting cognitive deficits of people with PD have revealed impairment in a variety of tasks related to memory, learning, visuospatial skills, and attention. In this chapter, we describe a general approach used to model PD and review three computational models that have been used to simulate cognitive deficits related to PD. The models presentation is followed by a discussion of the role of glia cells and astrocytes in neurodegenerative diseases. We propose that more biologically–realistic computational models of neurodegenerative diseases that include astrocytes may lead to a better understanding and treatment of neurodegenerative diseases in general and PD in particular.
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This research was funded in part by the National Institute of Mental Health, award #2R01MH063760.
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Hélie, S., Sajedinia, Z. (2019). Simulating Cognitive Deficits in Parkinson’s Disease. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_10
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DOI: https://doi.org/10.1007/978-3-030-18830-6_10
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