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Nephrolithiasis in the Elderly

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Clinical Nephrogeriatrics

Abstract

The geriatric population is both at higher risk of developing kidney stones and complications from medical or surgical treatment of stones. In this chapter, we review the risks for kidney stones and examine how these risk factors are affected by age. We also review current recommendations for treatment and suggest modifications to tailor therapy to the older age group.

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References

  1. Scales CD Jr, et al. Prevalence of kidney stones in the United States. Eur Urol. 2012;62(1):160–5.

    Article  Google Scholar 

  2. Soucie JM, et al. Demographic and geographic variability of kidney stones in the United States. Kidney Int. 1994;46(3):893–9.

    Article  CAS  Google Scholar 

  3. Otto BJ, et al. Age, body mass index, and gender predict 24-hour urine parameters in recurrent idiopathic calcium oxalate stone formers. J Endourol. 2017;31(12):1335–41.

    Article  Google Scholar 

  4. Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. J Am Soc Nephrol. 2009;20(10):2253–9.

    Article  CAS  Google Scholar 

  5. Fakheri RJ, Goldfarb DS. Association of nephrolithiasis prevalence rates with ambient temperature in the United States: a re-analysis. Kidney Int. 2009;76(7):798.

    Article  Google Scholar 

  6. Mass AY, Goldfarb DS, Shah O. Taxi cab syndrome: a review of the extensive genitourinary pathology experienced by taxi cab drivers and what we can do to help. Rev Urol. 2014;16(3):99–104.

    PubMed  PubMed Central  Google Scholar 

  7. Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med. 2010;363(10):954–63.

    Article  CAS  Google Scholar 

  8. Lieske JC, et al. Stone composition as a function of age and sex. Clin J Am Soc Nephrol. 2014;9(12):2141–6.

    Article  Google Scholar 

  9. Ferraro PM, et al. Dietary and lifestyle risk factors associated with incident kidney stones in men and women. J Urol. 2017;198(4):858–63.

    Article  Google Scholar 

  10. Borghi L, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002;346(2):77–84.

    Article  CAS  Google Scholar 

  11. Pearle MS, et al. Medical management of kidney stones: AUA guideline. J Urol. 2014;192(2):316–24.

    Article  Google Scholar 

  12. Skolarikos A, et al. Metabolic evaluation and recurrence prevention for urinary stone patients: EAU guidelines. Eur Urol. 2015;67(4):750–63.

    Article  Google Scholar 

  13. Escribano J, et al. Dietary interventions for preventing complications in idiopathic hypercalciuria. Cochrane Database Syst Rev. 2014;(2):Cd006022.

    Google Scholar 

  14. Qaseem A, et al. Dietary and pharmacologic management to prevent recurrent nephrolithiasis in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2014;161(9):659–67.

    Article  Google Scholar 

  15. Huen SC, Goldfarb DS. Adverse metabolic side effects of thiazides: implications for patients with calcium nephrolithiasis. J Urol. 2007;177(4):1238–43.

    Article  CAS  Google Scholar 

  16. Pannarale G. Optimal drug treatment of systolic hypertension in the elderly. Drugs Aging. 2008;25(1):1–8.

    Article  CAS  Google Scholar 

  17. Sakhaee K, et al. Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int. 2011;79(4):393–403.

    Article  CAS  Google Scholar 

  18. Usui Y, et al. Urolithiasis in geriatric patients. Tokai J Exp Clin Med. 2003;28(2):81–7.

    PubMed  Google Scholar 

  19. Rule AD, et al. The ROKS nomogram for predicting a second symptomatic stone episode. J Am Soc Nephrol. 2014;25(12):2878–86.

    Article  Google Scholar 

  20. Goldfarb DS, Parks JH, Coe FL. Renal stone disease in older adults. Clin Geriatr Med. 1998;14(2):367–81.

    Article  CAS  Google Scholar 

  21. Walker V, Stansbridge EM, Griffin DG. Demography and biochemistry of 2800 patients from a renal stones clinic. Ann Clin Biochem. 2013;50(2):127–39.

    Article  CAS  Google Scholar 

  22. Perinpam M, et al. Effect of demographics on excretion of key urinary factors related to kidney stone risk. Urology. 2015;86(4):690–6.

    Article  Google Scholar 

  23. Friedlander JI, et al. Age-related changes in 24-hour urine composition must be considered in the medical management of nephrolithiasis. J Endourol. 2014;28(7):871–6.

    Article  Google Scholar 

  24. Scales CD, et al. Urinary stone disease: advancing knowledge, patient care, and population health. Clin J Am Soc Nephrol. 2016;11(7):1305–12.

    Article  Google Scholar 

  25. Taylor EN, et al. Nephrolithiasis and risk of incident bone fracture. J Urol. 2016;195(5):1482–6.

    Article  Google Scholar 

  26. Carbone LD, et al. Urinary tract stones and osteoporosis: findings from the Women’s Health Initiative. J Bone Miner Res. 2015;30(11):2096–102.

    Article  Google Scholar 

  27. Lucato P, et al. Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis. Osteoporos Int. 2016;27(11):3155–64.

    Article  CAS  Google Scholar 

  28. Letavernier E, et al. Determinants of osteopenia in male renal-stone-disease patients with idiopathic hypercalciuria. Clin J Am Soc Nephrol. 2011;6(5):1149–54.

    Article  Google Scholar 

  29. Arrabal-Polo MA, et al. Effects of aminobisphosphonates and thiazides in patients with osteopenia/osteoporosis, hypercalciuria, and recurring renal calcium lithiasis. Urology. 2013;81(4):731–7.

    Article  Google Scholar 

  30. Pak CYC, et al. Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions. J Urol. 2003;169(2):465–9.

    Article  CAS  Google Scholar 

  31. Pipili C, Oreopoulos DG. Vitamin D status in patients with recurrent kidney stones. Nephron Clin Pract. 2012;122(3–4):134–8.

    Article  CAS  Google Scholar 

  32. Nguyen S, et al. 25-hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones. Am J Public Health. 2014;104(9):1783–7.

    Article  Google Scholar 

  33. Taylor EN, Hoofnagle AN, Curhan GC. Calcium and phosphorus regulatory hormones and risk of incident symptomatic kidney stones. Clin J Am Soc Nephrol. 2015;10(4):667–75.

    Article  CAS  Google Scholar 

  34. Tang J, Chonchol MB. Vitamin D and kidney stone disease. Curr Opin Nephrol Hypertens. 2013;22(4):383–9.

    Article  CAS  Google Scholar 

  35. Leaf DE, et al. Effect of vitamin D repletion on urinary calcium excretion among kidney stone formers. Clin J Am Soc Nephrol. 2012;7(5):829–34.

    Article  CAS  Google Scholar 

  36. Ferroni MC, et al. Vitamin D repletion in kidney stone formers: a randomized controlled trial. J Urol. 2017;197(4):1079–83.

    Article  CAS  Google Scholar 

  37. Jackson RD, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354(7):669–83.

    Article  CAS  Google Scholar 

  38. Bolland MJ, et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040.

    Article  Google Scholar 

  39. Kopecky SL, et al. Lack of evidence linking calcium with or without vitamin D supplementation to cardiovascular disease in generally healthy adults: a clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Ann Intern Med. 2016;165(12):867–8.

    Article  Google Scholar 

  40. Kuehn BM. Uspstf: taking vitamin d and calcium doesn’t prevent fractures in older women. JAMA. 2012;308(3):225–6.

    Article  CAS  Google Scholar 

  41. Moyer VA, U.S.P.S.T. Force∗. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;158(9):691–6.

    PubMed  Google Scholar 

  42. Harris SS, Dawson-Hughes B. Effects of hydration and calcium supplementation on urine calcium concentration in healthy postmenopausal women. J Am Coll Nutr. 2015;34(4):340–6.

    Article  CAS  Google Scholar 

  43. Levine BS, et al. Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: implications for prevention of osteoporosis. Am J Clin Nutr. 1994;60(4):592–6.

    Article  CAS  Google Scholar 

  44. Arrabal-Martin M, et al. Treatment with hydrochlorothiazide and alendronate in patients with stones and bone mineral density loss. Evolution of bone metabolism and calciuria with medical treatment. Arch Esp Urol. 2016;69(1):9–18.

    CAS  PubMed  Google Scholar 

  45. Jehle S, Hulter HN, Krapf R. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial. J Clin Endocrinol Metab. 2013;98(1):207–17.

    Article  CAS  Google Scholar 

  46. Keddis MT, Rule AD. Nephrolithiasis and loss of kidney function. Curr Opin Nephrol Hypertens. 2013;22(4):390–6.

    Article  Google Scholar 

  47. Ferraro PM, et al. History of kidney stones and the risk of coronary heart disease. JAMA. 2013;310(4):408–15.

    Article  CAS  Google Scholar 

  48. Alexander RT, et al. Kidney stones and cardiovascular events: a cohort study. Clin J Am Soc Nephrol. 2014;9(3):506–12.

    Article  Google Scholar 

  49. Daels FPJ, et al. Age-related prevalence of diabetes mellitus, cardiovascular disease and anticoagulation therapy use in a urolithiasis population and their effect on outcomes: the Clinical Research Office of the Endourological Society Ureteroscopy Global Study. World J Urol. 2015;33(6):859–64.

    Article  CAS  Google Scholar 

  50. Trinchieri A, Esposito N, Castelnuovo C. Dissolution of radiolucent renal stones by oral alkalinization with potassium citrate/potassium bicarbonate. Arch Ital Urol Androl. 2009;81(3):188–91.

    PubMed  Google Scholar 

  51. Drach GW, Griebling TL. Geriatric urology. J Am Geriatr Soc. 2003;51(7 Suppl):S355–8.

    Article  Google Scholar 

  52. Braude P, et al. Evaluation and establishment of a ward-based geriatric liaison service for older urological surgical patients: Proactive care of Older People undergoing Surgery (POPS)-Urology. BJU Int. 2017;120(1):123–9.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Section of Nephrology, Yale School of Medicine, New Haven, CT, USA

    Neera K. Dahl

  2. Nephrology Section, New York Harbor VA Healthcare System and NYU Langone Health, New York, NY, USA

    David S. Goldfarb

Authors
  1. Neera K. Dahl
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  2. David S. Goldfarb
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Corresponding author

Correspondence to Neera K. Dahl .

Editor information

Editors and Affiliations

  1. Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

  2. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    José Ricardo Jauregui

  3. Departamento de Medicina, Salamanca, Spain

    Juan Florencio Macías-Núñez

  4. University of Medicine “Grigore T. Popa” and University Hospital “C. I. Parhon”, Iasi, Romania

    Adrian Covic

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Dahl, N.K., Goldfarb, D.S. (2019). Nephrolithiasis in the Elderly. In: Musso, C., Jauregui, J., Macías-Núñez, J., Covic, A. (eds) Clinical Nephrogeriatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-18711-8_14

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  • DOI: https://doi.org/10.1007/978-3-030-18711-8_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18710-1

  • Online ISBN: 978-3-030-18711-8

  • eBook Packages: MedicineMedicine (R0)

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