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Innate Immunity

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Evolutionary Concepts in Immunology

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Abstract

All defence systems have much in common. No matter whether we are thinking in terms of defending a mediaeval castle from greedy neighbours or a multicellular eukaryote from attack by pathogens, the basic story is always the same. The defence system employed will consist of three parts. The first part provides information about whether a dangerous situation is developing. In the case of the castle, sentries will provide this necessary information. In the case of an animal’s innate immune system, soluble extracellular receptor molecules, and cell-associated sensors expressed by macrophages and other innate sentinel cells will detect incipient infections or other deviations from the homeostatic norm.

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Author information

Authors and Affiliations

  1. Department of Immunology, University of Greifswald, Greifswald, Germany

    Robert Jack

  2. Department of Environmental Sciences, Zoology, University of Basel, Basel Stadt, Switzerland

    Louis Du Pasquier

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  1. Robert Jack
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  2. Louis Du Pasquier
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Jack, R., Du Pasquier, L. (2019). Innate Immunity. In: Evolutionary Concepts in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-18667-8_3

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