Practical Points
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Allergic rhinitis and allergic asthma are common primary indications for allergen immunotherapy
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Immunological changes from immunotherapy include a decrease in mast cell and basophil degranulation, early increase and later decrease in allergen-specific IgE levels, increase in allergen-specific IgG, IgG4 and IgA levels, increase in regulatory T cells with an increase in IL-10 and TGF-β, and an immunological skewing from Th2 to Th1
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Cat, dust mites, ragweed and grass extracts are the only standardized environmental allergen extracts in the United States
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Patel, C., Ponda, P. (2019). Nasal Congestion Since Childhood. In: Rezaei, N. (eds) Pediatric Allergy. Springer, Cham. https://doi.org/10.1007/978-3-030-18282-3_8
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