Abstract
At the height of orchidomania in the nineteenth century, intrepid orchid collectors scoured the wild to search for beautiful, exotic plants to enhance the gardens of wealthy collectors. This search for new, rare and nearly extinct species continues despite the restrictions of CITES, but it is no longer intense. Biochemists are also treasure hunters. They search for compounds with pharmaceutical application in plants, and their search now extends to orchids. This chapter provides a simple introduction into the nature of the treasure hunt involving orchids. Compounds capable of protecting the body against diseases of old age, overindulgence or microbial invasion are primary targets in this search. An example is provided for the long and expensive journey between the initial discovery and actual clinical usage of a compound.
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References
Bajaj YPS (1999) Medicinal and aromatic plants XI, Biotechnology in agriculture and forestry, vol 43. Springer, Switzerland
Boller AH, Corrodi F, Gaumann E et al (1957) Uber induzierte Abwehrstoffe bei Orchideen Pt. 1. Helv Chim Acta 40:1062–1066
Bourgaud F, Gravot A, Milesi S, Gontier E (2001) Production of plant secondary metabolites: a historical perspective. Plant Sci 161:839–851
Chen KK, Chen AL (1935a) The alkaloid of Chin-shih-hu. J Biol Chem 111:653–658
Chen KK, Chen AL (1935b) The pharmacological action of dendrobine, the alkaloid of chin-shih-hu. J Pharamacol Exp Ther 55:319–325
Eagle H, Foley GE (1958) Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents. Cancer Res 18:1017–1025
Gong YQ, Fan Y, Wu DZ et al (2004) In vivo and in vitro evaluation of erianin, a novel anti-angiogenic agent. Eur J Cancer 40(10):1554–1565
Grace OM, Prendergast HDV, Jager AK, van Staden J (2002) The status of bark in South African health care. S A J Bot 68:21–30
Hardegger E, Schellenbaum M, Corrodi H (1963) Uber onduzierte Abwehrstoffe bei Orchideen. Part 2. Helv Chim Acta 46:1171–1180
Hur S, Kim T (2009a) Homoisoflavanone, an extract from Cremastra appendiculata Makino, inhibits inflammatory and allergic response in mast cell. J Invest Dermatol 129(Suppl. 1):S125
Hur S, Kim T (2009b) Homoisoflavanone, an extract from Cremastra appendiculata Makino, inhibits UVB-induced skin inflammation. J Invest Dermatol 129(Suppl. 1):S23
Hur SG, Lee YS, Yoo H et al (2010) Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxidagenase-2-expression and NF-kappa B nuclear localization. J Dermatol Sci 59(3):163–169
Kaiser N (1993) The scent of orchids: olfactory and chemical investigations. Editiones Roche, Basel
Lam F, Bradshaw TD, Mao H et al (2012) ZJU-6, a novel derivative of Erianin, shows potent anti-tubilin polymerization and anti-angiogenic activities. Investig New Drugs 30(5):1899–1907
Lee C-L, Nakagawa-Goto K, Yu D et al (2008) Cytotoxic Calanquinone A from Calanthe arisanensis and its first total synthesis. Bioorg Med Chem Lett 18(15):4275–4277
Li YM, Wang HY, Liu GQ (2001) Erianin induces apoptosis in human leukemia HL-60 cells. Acta Pharmacol Sin 22(11):1018–1012
Luning B (1974) Alkaloids of the Orchidaceae. In: Withner CL (ed) The orchids. Scientific studies. Wiley, New York
Massaoudi S, Hamze A, Provot O et al (2011) Discovery of isoerianin analogues as promising anticancer agents. ChemMedChem 6(3):488–497
Meissner W (1819) II. Ube rein neues Pflanzenalkali (Alkaloid). J Chem Phys 25:377–381
Muller CH (1966) The role of chemical inhibition (allelopathy) in vegetational composition. Bull Torrey Bot Club 93(5):332–351
Nickell LG (1962) Submerged growth of plant cells. Adv Appl Microbiol 4(1962):213–236
Shim JS, Kim JH, Lee J et al (2004) Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata. Planta Med 70(2):171–173
Stoessl A, Arditti J, 1984): Orchid phytoalexins. In: J Arditti Orchid biology. Reviews and perspectives, III. Ithaca: Cornell University Press
Suzuki H, Keimatsu I, Ito M (1932) Alkaloid of the Chinese drug ‘Chin Shih Hu’. II. Dendrobine. J Pharm Soc Japan 52:1049–1060
Teoh ES (2016) Medicinal orchids of Asia. Springer, Cham
Xia WB, Xue Z, Li S, Wang SJ, Yang YC, He DX, Ran GL, Kong LZ, Shi JG (2005) Chemical constituents from the tuber of Cremastra appendiculata. Zhongguo Zhong Yao Za Zhi 30(23):1827–1830
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Teoh, E.S. (2019). Modern Treasure Hunters. In: Orchids as Aphrodisiac, Medicine or Food. Springer, Cham. https://doi.org/10.1007/978-3-030-18255-7_8
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DOI: https://doi.org/10.1007/978-3-030-18255-7_8
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