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Bisphosphonate Infusion Therapy

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Infusion Therapy

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Abstract

Bisphosphonates (e.g., pamidronate, clodronate, alendronate) are pyrophosphate analogs, traditionally used in the treatment of pathologic conditions associated with abnormal bone metabolism, such as osteoporosis, Paget’s disease, and cancer-related bone pain. Recent research shows encouraging results regarding efficacy in often difficult to treat chronic pain syndromes including complex regional pain syndrome and osteoarthritic low back pain. These results combined with a benign safety profile makes bisphosphonate infusion an intriguing modality for physicians to consider for patients suffering from these conditions.

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References

  1. Yanow J, Pappagallo M, Pillai L. Complex regional pain syndrome (CRPS/RSD) and neuropathic pain: role of intravenous bisphosphonates as analgesics. Sci World J. 2008;8:229–36.

    Article  Google Scholar 

  2. Russell RGG. Bisphosphonates: mode of action and pharmacology. Pediatrics. 2007;119(Suppl 2):S150–62.

    Article  Google Scholar 

  3. Fleisch H. Bisphosphonates in osteoporosis. European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2003;12(Suppl 2):S142–6. https://doi.org/10.1007/s00586-003-0622-z.

  4. Brunner F, Schmid A, Kissling R, Held U, Bachmann LM. Biphosphonates for the therapy of complex regional pain syndrome I–systematic review. Eur J Pain. 2009;13(1):17–21.

    Article  CAS  Google Scholar 

  5. Maillefert JF, Chatard C, Owen S, Peere T, Tavernier C, Tebib J. Treatment of refractory reflex sympathetic dystrophy with pamidronate. Ann Rheum Dis. 1995;54(8):687.

    Article  CAS  Google Scholar 

  6. Cortet B, Flipo RM, Coquerelle P, Duquesnoy B, Delcambre B. Treatment of severe, recalcitrant reflex sympathetic dystrophy: assessment of efficacy and safety of the second generation bisphosphonate pamidronate. Clin Rheumatol. 1997;16(1):51–6.

    Article  CAS  Google Scholar 

  7. Kubalek I, Fain O, Paries J, Kettaneh A, Thomas M. Treatment of reflex sympathetic dystrophy with pamidronate: 29 cases. Rheumatology. 2001;40(12):1394–7.

    Article  CAS  Google Scholar 

  8. Robinson JN, Sandom J, Chapman PT. Efficacy of pamidronate in complex regional pain syndrome type I. Pain Med. 2004;5(3):276–80.

    Article  Google Scholar 

  9. Breuer B, Pappagallo M, Ongseng F, Chen CI, Goldfarb R. An open-label pilot trial of ibandronate for complex regional pain syndrome. Clin J Pain. 2008;24(8):685–9.

    Article  Google Scholar 

  10. Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A. Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: a systematic literature review and meta-analysis of randomized controlled trials versus placebo. Joint Bone Spine. 2017;84(4):393–9.

    Article  CAS  Google Scholar 

  11. Abdulla AJJ. Use of pamidronate for acute pain relief following osteoporotic vertebral fractures. Rheumatology. 2000;39(5):567–8.

    Article  CAS  Google Scholar 

  12. Gangji V, Appelboom T. Analgesic effect of intravenous pamidronate on chronic back pain due to osteoporotic vertebral fractures. Clin Rheumatol. 1999;18(3):266–7.

    Article  CAS  Google Scholar 

  13. Armingeat T, Brondino R, Pham T, Legré V, Lafforgue P. Intravenous pamidronate for pain relief in recent osteoporotic vertebral compression fracture: a randomized double-blind controlled study. Osteoporos Int. 2006;17(11):1659–65.

    Article  CAS  Google Scholar 

  14. Laroche M, Cantogrel S, Jamard B, Constantin A, Zabraniecki L, Cantagrel A, Mazières B. Comparison of the analgesic efficacy of pamidronate and synthetic human calcitonin in osteoporotic vertebral fractures: a double-blind controlled study. Clin Rheumatol. 2006;25(5):683–6.

    Article  CAS  Google Scholar 

  15. Poujol D, Ristori JM, Dubost JJ, Soubrier M. Efficacy of pamidronate in erosive degenerative disk disease: a pilot study. Joint Bone Spine. 2007;74(6):663–4.

    Article  Google Scholar 

  16. Feld J, Rosner I, Avshovich N, Boulman N, Slobodin G, Rozenbaum M. An open study of pamidronate in the treatment of refractory degenerative lumbar spinal stenosis. Clin Rheumatol. 2009;28(6):715–7.

    Article  Google Scholar 

  17. Pappagallo M, Breuer B, Lin HM, Moberly JB, Tai J, Noto C, et al. A pilot trial of intravenous pamidronate for chronic low back pain. Pain. 2014;155(1):108–17.

    Article  CAS  Google Scholar 

  18. Birklein F, Dimova V. Complex regional pain syndrome–up-to-date. Pain Rep. 2017;2(6):e624.

    Article  Google Scholar 

  19. Pamidronate [package insert]. Petah Tikva, Israel. Teva Parenteral Medicines, Inc; 2009.

    Google Scholar 

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Author information

Authors and Affiliations

  1. University of Pennsylvania Perelman School of Medicine, Department of Interventional Pain Medicine, Philadelphia, PA, USA

    Todd H. Ruth

  2. Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Veena Graff

Authors
  1. Todd H. Ruth
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  2. Veena Graff
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, University of Wisconsin, Madison, WI, USA

    Alaa Abd-Elsayed

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Ruth, T.H., Graff, V. (2019). Bisphosphonate Infusion Therapy. In: Abd-Elsayed, A. (eds) Infusion Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-17478-1_8

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  • DOI: https://doi.org/10.1007/978-3-030-17478-1_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-17477-4

  • Online ISBN: 978-3-030-17478-1

  • eBook Packages: MedicineMedicine (R0)

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