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Micro-CT in Comparison with Histology in the Qualitative Assessment of Bone and Pathologies

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Micro-computed Tomography (micro-CT) in Medicine and Engineering

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Abstract

Bone tissue along with cartilage, fibrous tissue, fat, blood vessels, nerves, and hematopoietic elements forms individual bones. Bone is highly mineralized and multifunctional tissue, which plays roles in mechanical support and protection, mineral homeostasis, and hematopoiesis. In recent years, it has become clear that bone also serves an essential endocrine function. To achieve these functional goals, bone is organized hierarchically, from nanometer- to millimeter-sized structures. This contributes not only to its mechanical role in support and movement of the body but also to its other functions. At the nanostructural level, bone is composed of organic and mineral components, mainly consisting of a matrix of cross-linked type I collagen mineralized with nanocrystalline, carbonated apatite. Due to its high mineral content, bone tissue is extremely resilient, but its organic part also provides a certain degree of flexibility and elasticity improving its behavior under mechanical forces.

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Acknowledgment

The specimen in this study were scanned and reconstructed with Skyscan 1275 (Skyscan, Kontich, Belgium) in Ankara University, Faculty of Dentistry, Micro CT Laboratory which was founded by Ankara University Research Fund (Project No: 17A0234001).

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Authors and Affiliations

  1. Faculty of Dentistry, Departments of Endodontics, Near East University, Nicosia, Mersin, Turkey

    Umut Aksoy

  2. Faculty of Medicine, Department of Pathology, Near East University, Nicosia, Mersin, Turkey

    Hanife Özkayalar

  3. Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara University, Ankara, Turkey

    Kaan Orhan

  4. Faculty of Medicine, OMFS IMPATH Research Group, Department of Imaging and Pathology, University of Leuven, Leuven, Belgium

    Kaan Orhan

  5. Oral and Maxillofacial Surgery, University Hospitals Leuven, University of Leuven, Leuven, Belgium

    Kaan Orhan

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  1. Umut Aksoy
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  2. Hanife Özkayalar
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  3. Kaan Orhan
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Correspondence to Umut Aksoy .

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  1. Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara University, Ankara, Turkey

    Kaan Orhan

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Aksoy, U., Özkayalar, H., Orhan, K. (2020). Micro-CT in Comparison with Histology in the Qualitative Assessment of Bone and Pathologies. In: Orhan, K. (eds) Micro-computed Tomography (micro-CT) in Medicine and Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-16641-0_8

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  • DOI: https://doi.org/10.1007/978-3-030-16641-0_8

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