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The Role of Anti-Angiogenic Agents (VEGF)

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Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners

Abstract

Angiogenesis refers to the growth of newly formed blood vessels from pre-existing vasculature (Wang et al., Oncotarget. 8:53854–72, 2017). Blocking the formation of blood vessels, theoretically, would stop a tumor from growing and metastasizing. For decades researchers have studied tumor growth and metastasis, ultimately discovering tumor-angiogenesis factor vascular endothelial growth factor (VEGF). This discovery led to a different way of treating cancer, blocking certain targets to stop tumor growth (targeted therapy). The discoveries of VEGF, immunotherapy, and driver mutations have changed the treatment paradigm of lung cancer.

There are two anti-angiogenic agents, bevacizumab and ramucirumab, used in combination with chemotherapy agents as first-line and second-line therapy for patients with non-small cell lung cancer (NSCLC). These agents provide an option for VEGF targeted therapy treatment for NSCLC with relatively manageable toxicities.

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Authors and Affiliations

  1. Department of Hematology/Oncology, University of California San Diego Moores Cancer Center, La Jolla, CA, USA

    Melinda Oliver

  2. Department of Thoracic/Head and Neck Medical Oncology, M.D. Anderson Cancer Center, Houston, TX, USA

    Melinda Oliver & Elizabeth S. Waxman

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  1. Melinda Oliver
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  2. Elizabeth S. Waxman
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Correspondence to Elizabeth S. Waxman .

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Editors and Affiliations

  1. Yale Comprehensive Cancer Center, Yale University School of Nursing, New Haven, CT, USA

    Marianne Davies

  2. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

    Beth Eaby-Sandy

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Oliver, M., Waxman, E.S. (2019). The Role of Anti-Angiogenic Agents (VEGF). In: Davies, M., Eaby-Sandy, B. (eds) Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners. Springer, Cham. https://doi.org/10.1007/978-3-030-16550-5_8

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