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Comprehensive Approach to Personalized Medicine into Chronic Musculoskeletal Diseases

The “BaR” Concept

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Personalized Medicine in Healthcare Systems

Part of the book series: Europeanization and Globalization ((EAG,volume 5))

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Abstract

Chronic musculoskeletal diseases, well known as osteoporosis and osteoarthritis, are among the most common diseases. Despite various pharmacological treatments, the problem of osteoporosis is not yet solved nor decreased. Drug’s adverse event and fractures after long termed pharmacotherapy indicate a need for new treatment modalities.

Regarding osteoarthritis, conventional clinical practice is based on symptomatic treatments with limited and temporary effect and in the severe cases surgically replacement of knee or hip with endo-prosthesis, are often left as the only option. There is no any prevention or treatment with the aim of improving the quality and functional ability of skeleton as a whole.

However, because of the intensive scientific research in the last two decades, significant advance in understanding of skeleton physiology, influence of metabolic and biomechanical factors on bone has been achieved. Those, as well as development of new technologies and treatment modalities, provide us with better possibilities for treatment and prevention of complications in chronic skeleton diseases. But, it also indicates a necessity of changing the clinical approach towards the principles of personalized and integrative medicine with the goal of improving bio-mechanical and metabolic balance, stimulating bone formation and cartilage regeneration, with consequent improvement of the functional capacity of the skeleton as a whole.

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Notes

  1. 1.

    Duque (2014) and Kanis et al. (2008).

  2. 2.

    Erviti et al. (2013) and Crilly et al. (2014).

  3. 3.

    Kamel (2007).

  4. 4.

    Krpan (2003).

  5. 5.

    Temiz-Artmann et al. (2005), Diegel et al. (2007), Jansen et al. (2006), Steinecker-Frohnwieser et al. (2014), Kullich et al. (2013a, b), Mařík et al. (2014), Kullich (2014), Steinecker-Frohnwieser et al. (2013), Krpan (2011), Steinecker-Frohnwieser et al. (2009), Kullich et al. (2006a, b), Auerbach et al. (2005), Kullich et al. (2005), Kullich and Ausserwinkler (2008), Fagerer (2007), Frobose et al. (2000), Krpan et al. (2015), Zhou et al. (2013), Jing et al. (2014), He et al. (2014), Handschuh and Melzer (2008) and Krpan and Kullich (2017).

  6. 6.

    Oliva and Egg (2017).

  7. 7.

    Krpan and Kullich (2017).

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Author information

Authors and Affiliations

  1. Polyclinic K-center, Zagreb, Croatia

    Dalibor Krpan

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  1. Dalibor Krpan
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Editors and Affiliations

  1. Faculty of Law, University of Rijeka, Rijeka, Croatia

    Nada Bodiroga-Vukobrat

  2. Croatian Academy of Sciences and Arts, Rijeka, Croatia

    Daniel Rukavina

  3. Juraj Dobrila University of Pula, Faculty of Medicine, Pula, Croatia

    Krešimir Pavelić

  4. Department of Biotechnology, Centre for High-Throughput Technologies, University of Rijeka, Rijeka, Croatia

    Krešimir Pavelić

  5. University of Applied Sciences, Ludwigsburg, Germany

    Gerald G. Sander

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Krpan, D. (2019). Comprehensive Approach to Personalized Medicine into Chronic Musculoskeletal Diseases. In: Bodiroga-Vukobrat, N., Rukavina, D., Pavelić, K., Sander, G.G. (eds) Personalized Medicine in Healthcare Systems. Europeanization and Globalization, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-030-16465-2_26

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  • DOI: https://doi.org/10.1007/978-3-030-16465-2_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16464-5

  • Online ISBN: 978-3-030-16465-2

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