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International Manual of Oncology Practice pp 945–958Cite as

Metabolic Disturbance

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Abstract

As specific cancer treatments evolved, our ability to anticipate side effects and prevent them has also been refined. Prophylaxis allows us to avoid numerous metabolic alterations, but it is still a frightening terrain in view of its clinical consequences. Knowing deeply the diagnostic steps and their management is of fundamental importance in the daily routine of the caregiver (Lawrence TS, Rosenberg SA: DeVita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. Lippincott Williams & Wilkins, Philadelphia, 2015).

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References

  1. Lawrence TS, Rosenberg SA (2015) DeVita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  2. Maier JD, Levine SN (2015) Hypercalcemia in the intensive care unit: a review of pathophysiology, diagnosis, and modern therapy. J Intensive Care Med 30(5):235–252

    Article  Google Scholar 

  3. Reagan P, Pani A, Rosner MH (2014) Approach to diagnosis and treatment of hypercalcemia in a patient with malignancy. Am J Kidney Dis 63(1):141–147

    Article  Google Scholar 

  4. Stewart AF (2005) Hypercalcemia associated with cancer. N Engl J Med 352(4):373–379

    Article  CAS  Google Scholar 

  5. Martins HS, Brandão Neto RA, Velasco IT (2016) Medicina de emergências: abordagem prática. Manole, Barueri

    Google Scholar 

  6. Pi J, Kang Y, Smith M, Earl M, Norigian Z, McBride A (2016) A review in the treatment of oncologic emergencies. J Oncol Pharm Pract 22(4):625–638

    Article  CAS  Google Scholar 

  7. Ahmad S, Kuraganti G, Steenkamp D (2015) Hypercalcemic crisis: a clinical review. Am J Med 128(3):239–245

    Article  CAS  Google Scholar 

  8. Daniels E, Sakakeeny C (2015) Hypercalcemia: pathophysiology, clinical signs, and emergent treatment. J Am Anim Hosp Assoc 51(5):291–299

    Article  Google Scholar 

  9. Sternlicht H, Glezerman IG (2015) Hypercalcemia of malignancy and new treatment options. Ther Clin Risk Manag 11:1779

    CAS  PubMed  PubMed Central  Google Scholar 

  10. LeGrand SB, Leskuski D, Zama I (2008) Narrative review: furosemide for hypercalcemia: an unproven yet common practice furosemide for hypercalcemia. Ann Intern Med 149(4):259–263

    Article  Google Scholar 

  11. Kawada K, Minami H, Okabe K, Watanabe T, Inoue K, Sawamura M et al (2005) A multicenter and open label clinical trial of zoledronic acid 4 mg in patients with hypercalcemia of malignancy. Jpn J Clin Oncol 35(1):28–33

    Article  Google Scholar 

  12. Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen H et al (2001) Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 19(2):558–567

    Article  CAS  Google Scholar 

  13. Wagner J, Arora S (2014) Oncologic metabolic emergencies. Emerg Med Clin North Am 32(3):509–525

    Article  Google Scholar 

  14. Mirrakhimov AE (2015) Hypercalcemia of malignancy: an update on pathogenesis and management. N Am J Med Sci 7(11):483–493

    Article  Google Scholar 

  15. Howard SC, Jones DP, Pui C-H (2011) The tumor lysis syndrome. N Engl J Med 2011(364):1844–1854

    Article  Google Scholar 

  16. Mirrakhimov AE, Voore P, Khan M, Ali AM (2015) Tumor lysis syndrome: a clinical review. World J Crit Care Med 4(2):130–138

    Article  Google Scholar 

  17. Cairo MS, Bishop M (2004) Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol 127(1):3–11

    Article  Google Scholar 

  18. Mughal TI, Ejaz AA, Foringer JR, Coiffier B (2010) An integrated clinical approach for the identification, prevention, and treatment of tumor lysis syndrome. Cancer Treat Rev 36(2):164–176

    Article  Google Scholar 

  19. Coiffier B, Altman A, Pui C-H, Younes A, Cairo MS (2008) Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 26(16):2767–2778

    Article  CAS  Google Scholar 

  20. Edeani A, Shirali A (2016) Tumor lysis syndrome

    Google Scholar 

  21. Smalley RV, Guaspari A, Haase-Statz S, Anderson SA, Cederberg D, Hohneker JA (2000) Allopurinol: intravenous use for prevention and treatment of hyperuricemia. J Clin Oncol 18(8):1758–1763

    Article  CAS  Google Scholar 

  22. Wilson FP, Berns JS (2014) Tumor lysis syndrome: new challenges and recent advances. Adv Chronic Kidney Dis 21(1):18–26

    Article  Google Scholar 

  23. Berghmans T, Paesmans M, Body J-J (2000) A prospective study on hyponatraemia in medical cancer patients: epidemiology, aetiology and differential diagnosis. Support Care Cancer 8(3):192–197

    Article  CAS  Google Scholar 

  24. Doshi SM, Shah P, Lei X, Lahoti A, Salahudeen AK (2012) Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes. Am J Kidney Dis 59(2):222–228

    Article  CAS  Google Scholar 

  25. Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH et al (2013) Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med 126(10):S1–S42

    Article  Google Scholar 

  26. Ellison DH, Berl T (2007) The syndrome of inappropriate antidiuresis. N Engl J Med 356(20):2064–2072

    Article  CAS  Google Scholar 

  27. Yu Z, Parker KM, Blick KE (2005) Markedly decreased serum sodium concentration in a patient with multiple myeloma. Lab Med 36(4):224–226

    Article  Google Scholar 

  28. Chute JP, Taylor E, Williams J, Kaye F, Venzon D, Johnson BE (2006) A metabolic study of patients with lung cancer and hyponatremia of malignancy. Clin Cancer Res 12(3):888–896

    Article  CAS  Google Scholar 

  29. Peri A (2013) The use of vaptans in clinical endocrinology. J Clin Endocrinol Metabol 98(4):1321–1332

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medical Oncology, Universidade Federal de São Paulo, São Paulo, SP, Brazil

    Pamela Carvalho Muniz

  2. Department of Medical Oncology, São Paulo University Hospital, Federal University of São Paulo, São Paulo, SP, Brazil

    Mayndra Mychelle Landgraf & Michelle Samora de Almeida

  3. Department of Medical Oncology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil

    Fernando Silva Picon

  4. Division of Medical Oncology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil

    Hakaru Tadokoro

  5. Division of Medical Oncology, Federal University of São Paulo (UNIFESP) & Hospital Israelita Albert Einstein, São Paulo, Brazil

    Ramon Andrade De Mello

  6. Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

    Ramon Andrade De Mello

Authors
  1. Pamela Carvalho Muniz
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  2. Mayndra Mychelle Landgraf
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  3. Fernando Silva Picon
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  4. Hakaru Tadokoro
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  5. Ramon Andrade De Mello
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  6. Michelle Samora de Almeida
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Corresponding author

Correspondence to Ramon Andrade De Mello .

Editor information

Editors and Affiliations

  1. Division of Medical Oncology, Federal University of São Paulo (UNIFESP) & Hospital Israelita Albert Einstein, São Paulo, Brazil, Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

    Ramon Andrade De Mello

  2. Oncology Department, Henry Dunant Hospital Center, Athens, Greece

    Giannis Mountzios

  3. Department of Biomedical Sciences and Medicine, Universidade do Algarve, Faro, Portugal

    Álvaro A. Tavares

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Muniz, P.C., Landgraf, M.M., Picon, F.S., Tadokoro, H., De Mello, R.A., de Almeida, M.S. (2019). Metabolic Disturbance. In: De Mello, R., Mountzios, G., Tavares, Á. (eds) International Manual of Oncology Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-16245-0_42

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