Abstract
Penile cancer is a rare tumor. The annual incidence is estimated to be 1 in 100,000 males, accounting for less than 1% of all cancers in men. Regarding histology it consists of squamous cells in 95% of cases. Treatment modalities include surgery, radiotherapy and chemotherapy. Early diagnosis is important since advanced disease is related not only with worse prognosis but also with impaired quality of life.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mansur D (2013) Cancer of the penis and male urethra. In: Perez and Brady’s principles and practice of radiation oncology, 6th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1345–1354
Schoen EJ, Oehrli M, Colby CJ et al (2000) The highly protective effect of newborn circumcision against invasive penile cancer. Pediatrics 105:E36
Miralles-Guri C, Bruni L, Cubilla AL et al (2009) Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 62:870–878
Barroso LF, Wilkins T (2011) Human papillomavirus vaccination in males: the state of the science. Curr Infect Dis Rep 13:175–181
Kumar S, Ananthakrishnan N, Prema V (1998) Predicting regional lymph node metastasis in carcinoma of the penis: a comparison between fine-needle aspiration cytology, sentinel lymph node biopsy and medial inguinal lymph node biopsy. Br J Urol 81:453–457
Schlenker B, Scher B, Tiling R et al (2012) Detection of inguinal lymph node involvement in penile squamous cell carcinoma by 18F-florodeoxyglucose PET/CT: a prospective single-center study. Urol Oncol 30(1):55–59
Graafland NM, Leijte JAP, Valdes Olmos RA et al (2009) Scanning with 18F-FDG-PET/ CT for detection of pelvic nodal involvement in inguinal node- positive penile carcinoma. Eur Urol 56:339–345
Villavicencio H, Rubio-Briones J, Regalado R et al (1997) Grade, local stage and growth pattern as prognostic factors in carcinoma of the penis. Eur Urol 32:442–447
Shapiro D, Shasha D, Tareen M et al (2011) Contemporary management of localized penile cancer. Expert Rev Anticancer Ther 11(1):29–36
Solsana E, Bahl A, Brandes SB et al (2010) New developments in the treatment of localized penile cancer. Urology 76(2, Suppl 1):S36–S42
Colberg JW, Andriole GL, Catalona WJ (1997) Long-term follow-up of men undergoing modified inguinal lymphadenectomy for carcinoma of the penis. Br J Urol 79:54–57
Solsona E, Iborra I, Rubio J et al (2001) Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 165:1506–1509
Perinetti E, Crane DB, Catalona WJ (1980) Unreliability of sentinel lymph node biopsy for staging penile carcinoma. J Urol 124:734–735
Protzel C, Seitz AK, Hakenberg OW et al (2013) Neoadjuvant, adjuvant and palliative chemotherapy of penile cancer. Urologe A 52(11):1556–1560
Zanetta G, Lissoni A, Pellegrino A et al (1998) Neoadjuvant chemotherapy with cisplatin, ifosfamide and paclitaxel for locally advanced squamous-cell cervical cancer. Ann Oncol 9(9):977–980
Sonpavde G, Pagliaro LC, Buonerba C et al (2013) Penile cancer: current therapy and future directions. Ann Oncol 24(5):1179–1189
Pagliaro LC, Williams DL, Daliani D et al (2010) Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol 28(24):3851–3857
Langsenlehner T, Mayer R, Quehenberger F, Prettenhofer U, Langsenlehner U, Pummer K, Kapp KS (2008) The role of radiation therapy after incomplete resection of penile cancer. Strahlenther Onkol 184(7):359–363
Johnson TV, Hsiao W, Delman KA, Jani AB, Brawley OW, Master VA (2010) Extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancer patients: results from the Surveillance, Epidemiology, and End Results program. Cancer 116(12):2960–2966
Wood DP (2011) Re: extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancerpatients: results from the surveillance, epidemiology, and end results program. J Urol 185(4):1282
Burt LM, Shrieve DC, Tward JD (2014) Stage presentation, care patterns, and treatment outcomes for squamous cell carcinoma of the penis. Int J Radiat Oncol Biol Phys 88(1):94–100
Crook J, Mazeron JJ (2012) Penile Cancer. In: Gunderson L, Tepper J (eds) Clinical radiation oncology, 3rd edn. Elsevier Saunders, Philadelphia, pp 1167–1176
De Crevoisier R, Slimane K, Sanfilippo N et al (2009) Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys 74:1150–1156
Delaunay B, Soh PN, Delannes M et al (2014) Brachytherapy for penile cancer: efficacy and impact on sexual function. Brachytherapy 13(4):380–387
Hasan S, Francis A, Hagenauer A, Hirsh A, Kaminsky D, Traughber B, Abouassaly R, Ellis R (2015) The role of brachytherapy in organ preservation for penile cancer: a meta-analysis and review of the literature. Brachytherapy 1538–4721(15):00456
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Tsoukalas, N., Tsapakidis, K., Kyrgias, G., Tolia, M. (2019). Penile Cancer. In: De Mello, R., Mountzios, G., Tavares, Á. (eds) International Manual of Oncology Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-16245-0_30
Download citation
DOI: https://doi.org/10.1007/978-3-030-16245-0_30
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-16244-3
Online ISBN: 978-3-030-16245-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)