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Experimental Laceration Spinal Cord Injury Model in Rodents

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Animal Models of Acute Neurological Injury

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Experimental laceration spinal cord injury (l-SCI) is an important in vivo model to investigate mechanisms of axonal regeneration and neurite plasticity following SCI. l-SCI is customarily performed freehand under visual guidance that results in variable lesion depths and shapes. In this chapter, a precise l- SCI model will be described for rodents using the Louisville Injury System Apparatus (LISA). This method incorporates: (1) reliable vertebral stabilization and spinal cord exposure and (2) accurate tissue laceration without contusion.

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Acknowledgment

We acknowledge Norton Healthcare for their continued support.

Author information

Authors and Affiliations

  1. Norton Neuroscience Institute, Norton Healthcare, Louisville, KY, USA

    Yi Ping Zhang, Lisa B. E. Shields & Christopher B. Shields

  2. Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA

    Christopher B. Shields

Authors
  1. Yi Ping Zhang
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  2. Lisa B. E. Shields
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  3. Christopher B. Shields
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Corresponding author

Correspondence to Lisa B. E. Shields .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu

  3. Indiana University School of Medicine, SNRI SCBIRG, Indianapolis, IN, USA

    Xiao Ming Xu

  4. Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

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Zhang, Y.P., Shields, L.B.E., Shields, C.B. (2019). Experimental Laceration Spinal Cord Injury Model in Rodents. In: Chen, J., Xu, Z., Xu, X., Zhang, J. (eds) Animal Models of Acute Neurological Injury. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16082-1_35

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  • DOI: https://doi.org/10.1007/978-3-030-16082-1_35

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16080-7

  • Online ISBN: 978-3-030-16082-1

  • eBook Packages: MedicineMedicine (R0)

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