Skip to main content

Evaluation and Management of Pediatric Nephrolithiasis

  • Chapter
  • First Online:
Nutritional and Medical Management of Kidney Stones

Part of the book series: Nutrition and Health ((NH))

  • 1087 Accesses

Abstract

The incidence of nephrolithiasis in pediatrics is increasing. All children with nephrolithiasis should have a complete metabolic evaluation on initial presentation, as a metabolic risk factor may be found in the majority of children. Careful consideration in pediatric nephrolithiasis of rare genetic causes of kidney stones disease should be at the forefront of the evaluation, as many of these disorders present in childhood and are associated with a lifetime of morbidities related to nephrolithiasis as well as the risk for development of chronic kidney disease. Treatment of the underlying metabolic risk factors helps prevent further stone formation and the morbidities associated with stone formation, such as pain, surgery, and chronic kidney disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Taisan GE, Ross ME, Liahi S, et al. Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997–2012, with a particular increase in the adolescent female population. Clin J Am Soc Nephrol. 2016;11(3):488–96.

    Article  Google Scholar 

  2. Novak TE, Lakshmanan Y, Trock BJ, et al. Sex prevalence of pediatric kidney stone disease in the United States. Urology. 2009;74(1):104–7.

    Article  PubMed  Google Scholar 

  3. Dwyer ME, Krambeck AE, Bergstralh EJ, et al. Temporal trends in incidence of kidney stones among children: a 25-year population based study. J Urol. 2012;188:247–52.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Bonzo JR, Taisan GE. The emergence of kidney stone disease during childhood—impact on adults. Curr Urol Rep. 2017;18(44):1–6.

    Google Scholar 

  5. Tasian GE, Kabarriti AE, Kalmus A, et al. Kidneystone recurrence among children and adolescents. J Urol. 2017;197:246–52.

    Article  PubMed  Google Scholar 

  6. Cameron MA, Sakhaee K, Moe OW. Nephrolithiasis in children. Pediatr Nephrol. 2005;20:1587–92.

    Article  PubMed  Google Scholar 

  7. Hoppe B, Kemper MJ. Diagnostic examination of the child with urolithiasis or nephrocalcinosis. Pediatr Nephrol. 2010;25:403–13.

    Article  PubMed  Google Scholar 

  8. Spivacow FR, Negri AL, del Valle EE, et al. Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol. 2008;23:1129–33.

    Article  PubMed  Google Scholar 

  9. Cochat P, Pichault V, Bacchetta J, et al. Nephrolithiasis related to inborn metabolic disease. Pediatr Nephrol. 2010;25:415–24.

    Article  PubMed  Google Scholar 

  10. Edvardsson V, Goldfarb D, Lieske J, et al. Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol. 2013;28:1923–42.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Braun DA, Lawson JA, Gee HY, et al. Prevalence of monogenic causes in pediatric patients with nephrolithiasis or nephrocalcinosis. Clin J Am Soc Nephrol. 2016;11(4):664–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Daga A, Majmundar AJ, Braun DA, Gee HY, et al. Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and Nephrocalcinosis. Kidney Int. 2018;93(1):204–13.

    Article  CAS  PubMed  Google Scholar 

  13. Guven AG, Koyun M, Baysal YE, et al. Urolithiasis in the first year of life. Pediatr Nephrol. 2010;25:129–34.

    Article  PubMed  Google Scholar 

  14. Poito C, La Manna A, Signoriello G, Marte A. Recurrent abdominal pain in childhood urolithiasis. Pediatrics. 2009;124(6):e1088–94.

    Article  Google Scholar 

  15. Schell-Feith EA, Kist-van Holthe JE, van der Heijden AJ. Nephrocalcinosis in preterm infants. Pediatr Nephrol. 2010;25:221–30.

    Article  PubMed  Google Scholar 

  16. Skolarikos A, Dellis A, Knoll T. Ureteropelvic obstruction and renal stones: etiology and treatment. Urolithiasis. 2015;43(1):5–12.

    Article  PubMed  Google Scholar 

  17. Stephany HA, Clayton DB, Tanaka ST, et al. Development of upper tract stones in patients with congenital neurogenic bladder. J Pediatr Urol. 2014;10(1):112–7.

    Article  PubMed  Google Scholar 

  18. Raj GV, Auge BK, Assimos D, et al. Metabolic abnormalities associated with renal calculi in patients with horseshoe kidneys. J Endourol. 2004;18(2):157–61.

    Article  PubMed  Google Scholar 

  19. Nazzal L, Puri S, Goldfarb D. Enteric hyperoxaluria: an important cause of end-stage kidney disease. Nephrol Dial Transplant. 2016;31L:375–82.

    Article  Google Scholar 

  20. Asplin J. The management of patients with enteric hyperoxaluria. Urolithiasis. 2016;44:33–43.

    Article  CAS  PubMed  Google Scholar 

  21. Gibeny E, Goldfarb D. The association of nephrolithiasis with cystic fibrosis. Am J Kidney Dis. 2003;42:1–11.

    Article  Google Scholar 

  22. Pober B. Williams-Beuren syndrome. N Engl J Med. 2010;362:239–52.

    Article  CAS  PubMed  Google Scholar 

  23. Weinstein DA, Somers MJ, Wolfsdorf JI. Decreased urinary citrate excretion in type 1a glycogen storage disease. J Pediatr. 2001;138(3):378–82.

    Article  CAS  PubMed  Google Scholar 

  24. Rake J, Visser G, Labrune P, et al. Guidelines for management of glycogen storage disease type 1—European study on glycogen storage disease type 1 (ESGSD 1). Eur J Pediatr. 2002;161(1):S112–9.

    Article  PubMed  Google Scholar 

  25. McNally M, Pyzik P, Rubenstein J, et al. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics. 2009;124:e300–4.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Kossoff E, Pyzik P, Furth S, et al. Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet. Epilepsia. 2002;43(10):1168–71.

    Article  PubMed  Google Scholar 

  27. Blank S, Scanlon KS, Sinks TH, et al. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home delivery-dairy. Am J Public Health. 1995;85(5):656–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol. 2003;2(1):397–401.

    Article  Google Scholar 

  29. Saltel E, Angel JB, Futter NG, et al. Increased prevalence and analysis of risk factors for indinavir nephrolithiasis. J Urol. 2000;164(6):1895–7.

    Article  CAS  PubMed  Google Scholar 

  30. Raheem O, Mirheydar H, Palazzi K, et al. Prevalence of nephrolithiasis in human immunodeficiency virus infected patients on the highly active antiretroviral therapy. J Endourol. 2012;26(8):1095–8.

    Article  PubMed  Google Scholar 

  31. Grant MT, Eisner BH, Bechis SK. Ureteral obstruction due to radiolucent atazanavir ureteral stone. J Endourol Case Rep. 2017;3(1):152–4.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Rockwood N, Mandalia S, Bower M. Ritonavir boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir. AIDS. 2011;25(13):1671–3.

    Article  CAS  PubMed  Google Scholar 

  33. Azvi Z, Koktener A, Uras N, et al. Nephrolithiasis associated with ceftriaxone therapy a prospective study in 51 children. Arch Dis Child. 2004;11:1069–72.

    Google Scholar 

  34. Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. J Am Soc Nephrol. 2009;20(10):2253–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Nouvenne A, Ticinesi A, Morelli I, et al. Fad diets and their effect on urinary stone formation. Transl Androl Urol. 2014;3(3):303–12.

    PubMed  PubMed Central  Google Scholar 

  36. Lopez M, Hoppe B. History epidemiology and regional diversities of urolithaisis. Pediatr Nephrol. 2010;25:49–59.

    Article  PubMed  Google Scholar 

  37. Coe F, Parks JH, Moore ES. Familial idiopathic hypercalciuria. NEJM. 1979;300:337–40.

    Article  CAS  PubMed  Google Scholar 

  38. Passerotti C, Chow JS, Silva A, et al. Ultrasound versus computerized tomography for evaluation of urolithiasis. J Urol. 2009;182(4 suppl):1829–34.

    Article  PubMed  Google Scholar 

  39. Coe F, Worcester E, Evan A. Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol. 2016;12(9):519–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Hoppe B, Beck BB, Milliner DS. The primary hyperoxalurias. Kidney Int. 2009;75:1264–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Sumorok N, Goldfarb D. Update on cystinuria. Curr Opin Nephrol Hypertens. 2013;22(4):427–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Wang SS, Devuyst O, Courtoy PJ, et al. Mice lacking renal chloride channel CLC-5 are a model for Dent’s disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet. 2000;9:2937–45.

    Article  CAS  PubMed  Google Scholar 

  43. Hoopes RR Jr, Shrimpton AE, Knohl SJ, et al. Dent disease with mutations in OCRL1. Am J Hum Genet. 2005;76:260–7.

    Article  CAS  PubMed  Google Scholar 

  44. Williams-Larson AW. Urinary calculi associated with purine metabolism. Uric acid nephrolithiasis. Endocrinol Metab Clin N Am. 1990;19(4):821–38.

    Article  CAS  Google Scholar 

  45. Torres R, Puig J, Jinnah H. Update on the phenotypic spectrum of Lesch-Nyhan disease and its attenuated variants. Curr Rheumatol Rep. 2012;14(2):189–94.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Jones DP, Mahmoud H, Chesney RW. Tumor lysis syndrome: pathogenesis and management. Pediatr Nephrol. 1995;9(2):206–12.

    Article  CAS  PubMed  Google Scholar 

  47. Goldman SC, Holcenberg JS, Finklestein JZ, et al. Randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97(10):2998–3003.

    Article  CAS  PubMed  Google Scholar 

  48. Edvardsson V, Palsson R, Olafsson I, et al. Clinical features and genotype of adenine phosphoribosyltransferase deficiency in Iceland. Am J Kidney Dis. 2001;38:473–90.

    Article  CAS  PubMed  Google Scholar 

  49. Bollee G, Dollinger C, Boutaaud L, et al. Phenotype and genotype characterization of adenine phosphoribosyltransferase deficiency. J Am Soc Nephrol. 2010;21:679–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Matos V, van Melle G, Boulat O, et al. Urinary phosphate/creatinine, calcium/creatinine, and magnesium/creatinine ratios in a healthy pediatric population. J Pediatr. 1997;131:252–7.

    Article  CAS  PubMed  Google Scholar 

  51. Miliner DS. Urolithiasis. In: Avner ED, Harmon WE, Niaudet P, Yoshikawa N, editors. Pediatric nephrology, Vol. 2. 6th ed. Berlin/Heidelberg: Springer; 2009. p. 1405–30.

    Chapter  Google Scholar 

  52. So NP, Osoria AV, Simon SD, et al. Normal urinary calcium/creatinine ratios in African-American and Caucasian children. Pediatr Nephrol. 2001;16:133–9.

    Article  CAS  PubMed  Google Scholar 

  53. Polinsky MS, Kaiser BA, Baluarte HJ, et al. Renal stones and hypercalciuria. In: Barnes LA, DeVivo DC, Kaback MM, Morrow G, Oski FA, Rudolph AM, editors. Advances in pediatrics, vol. 40. St. Louis: Mosby; 1993. p. 353–84.

    Google Scholar 

  54. Matoo A, Goldfarb DS. Cystinuria. Semin Nephrol. 2008;28(2):181–91.

    Article  Google Scholar 

  55. Baum MA. Approach to stone formation in the pediatric population. Clin Rev Bone Miner Metab. 2012;10:50–60.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michelle A. Baum .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Baum, M.A. (2019). Evaluation and Management of Pediatric Nephrolithiasis. In: Han, H., Mutter, W., Nasser, S. (eds) Nutritional and Medical Management of Kidney Stones. Nutrition and Health. Humana, Cham. https://doi.org/10.1007/978-3-030-15534-6_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-15534-6_23

  • Published:

  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-15533-9

  • Online ISBN: 978-3-030-15534-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics