Abstract
The work was related to study of the impact of material on the tissue. A synthetic material of the type of tissue analogue was developed. A disadvantage of synthetic materials is their instability, in particularly in the environmental fluids. Within the framework of the statutory test silver nanoparticles deposited by magnetron sputtering were conducted delivering its stabilization. Silver nanoparticles were introduced into the polyelectrolyte structure, in order to reduce the risk of the bacterial biofilm formation. The introduction of Ag nanoparticles was followed by deposition under high vacuum by magnetron sputtering. The analysis of the blood-material interactions was conducted using commercially available tester, Impact-R (Diamed). The assessment of silver ions assessment into plasma was tested based on prothrombin time (PT) and activated partial thromboplastin time (APTT). The unmodified surface of the polyelectrolyte is a potential activator of blood elements. The introduction of silver nanoparticles reduced the likelihood of clotting. Extrinsic coagulation pathway determined on the basis of internal PT and APTT coagulation pathways did not indicate hazards beyond the acceptable range.
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Acknowledgements
The research was financially supported by the Project no. 2016/23/B/ST8/01481 ‘Interdisciplinary methods of creating and functioning of biomimetic materials based on Animal origin extracellular matrix’ of the Polish National Center of Science. Part of the work was co-financed by NCN: 2014/15/B/ST8/00103 and the European Union from resources of the European Social Fund (Project No. WND-POWR.03.02.00-00-I043/16).
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Major, R., Imbir, G., Mzyk, A., Wilczek, P., Sanak, M., Lackner, J.M. (2019). Stabilization of Synthetic Materials with Silver Particles. In: Tkacz, E., Gzik, M., Paszenda, Z., Piętka, E. (eds) Innovations in Biomedical Engineering. IBE 2018. Advances in Intelligent Systems and Computing, vol 925. Springer, Cham. https://doi.org/10.1007/978-3-030-15472-1_34
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