Skip to main content
SpringerLink
Log in

Natural Value-Added Compounds from Fungal Communities

  • Chapter
  • First Online:
Recent Advancement in White Biotechnology Through Fungi

Part of the book series: Fungal Biology ((FUNGBIO))

  • 1211 Accesses

Abstract

Since ancient times, fungi and fungal products have gained noticeable attention for pharmaceutical applications and even for human consumption. Recent research has provided significant evidence of fungal metabolites with a wide variety of biological activities. The bioactive compounds from fungal communities are exploited by industrial sectors from the basic biomass-based food and feed application as nutraceutials to high-value pharmaceutical, cosmeceutical, ecological, and biomedical applications. Recent advances in scientific knowledge include interest in the use of natural value-added products, especially from fungi. Fungal communities provide highly diversified value-added products with complex chemical structures impossible or difficult to produce by chemical synthetic methods. Recent efforts have explored novel endophytic fungi which are added to the list of potential providers of value-added products. Functional genomics and proteomics facilitate the isolation and production of novel metabolites from fungi. Genetic engineering is an useful tool to metabolically engineer the microorganism for the production of value-added compounds. Various high-throughput screening methods are gaining importance for the rapid detection and isolation of bioactive compounds from fungi.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Amirkia V, Heinrich M (2014) Alkaloids as drug leads: a predictive structural and biodiversity-based analysis. Phytochem Lett 10:43–53

    Article  CAS  Google Scholar 

  • Balasundram N, Sundram K, Samman S (2006) Phenolic compounds in plants and agri-industrial by-products: antioxidant activity, occurrence, and potential uses. Food Chem 99(1):191–203

    Article  CAS  Google Scholar 

  • Barman S, Sit N, Badwaik LS, Deka SC (2014) Pectinase production by Aspergillus niger using banana (Musa balbisiana) peel as substrate and its effect on clarification of banana juice. J Food Sci Technol 43:591–595

    Google Scholar 

  • Bond C, Tang Y, Li L (2016) Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genet Biol 89(3):52–61

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burruano S, Giambra S, Mondello V, Dellagreca M, Basso S, Angela T, Andolfi A (2016) Naphthalenone polyketides produced by Neofusicoccum parvum, a fungus associated with grapevine Botryosphaeria dieback. Phytopathol Mediterr 55:197–206

    CAS  Google Scholar 

  • Caputi L, Aprea E (2011) Use of terpenoids as natural flavouring compounds in food industry. Recent Pat Food Nutr Agric 3(1):9–16

    Article  CAS  PubMed  Google Scholar 

  • Chandrasekaran M, Sathiyabama M (2014) Production, partial purification and characterization of protease from a phytopathogenic fungi Alternaria solani (Ell. and Mart.) Sorauer. J Basic Microbiol 54(8):763–774

    Article  CAS  PubMed  Google Scholar 

  • Chandrasekaran S, Kumaresan S, Manavalan M (2015) Production and optimization of protease by filamentous fungus isolated from paddy soil in Thiruvarur District Tamilnadu. J Appl Biol Biotechnol 3(6):66–69

    CAS  Google Scholar 

  • da Silva VC, Rodrigues CM (2014) Natural products: an extraordinary source of value-added compounds from diverse biomasses in Brazil. Chem Biol Technol Agric 1(1):14

    Article  CAS  Google Scholar 

  • de Souza JJ, Vieira IJC, Rodrigues-Filho E, Braz-Filho R (2011) Terpenoids from endophytic fungi. Molecules 16(12):10604–10618

    Article  PubMed  PubMed Central  Google Scholar 

  • Daley DK, Brown KJ, Badal S (2017) Chapter 20 - Fungal metabolites. In: Badal S, Delgoda RBT-P (eds) Pharmacognosy. Academic Press, Boston, pp 413–421

    Chapter  Google Scholar 

  • Deepika VB, Murali TS, Satyamoorthy K (2016) Modulation of genetic clusters for synthesis of bioactive molecules in fungal endophytes: a review. Microbiol Res 182:125–140

    Article  CAS  PubMed  Google Scholar 

  • Du J, Shao Z, Zhao H (2011) Engineering microbial factories for synthesis of value-added products. J Ind Microbiol Biotechnol 38(8):873–890

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fujii I (2010) Functional analysis of fungal polyketide biosynthesis genes. J Antibiot (Tokyo) 63(5):207–218

    Article  CAS  Google Scholar 

  • Gao Z, Li B, Zheng C, Wang G (2008) Molecular detection of fungal communities in the Hawaiian marine sponges Suberites zeteki and Mycale armata. Appl Environ Microbiol 74(19):6091–6101

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garrido-Arandia M, Silva-Navas J, Ramírez-Castillejo C, Cubells-Baeza N, Gómez-Casado C, Barber D, Díaz-Perales A (2016) Characterisation of a flavonoid ligand of the fungal protein Alt a 1. Sci Rep 6(1):33468

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geoffry K, Achur RN (2018) Screening and production of lipase from fungal organisms. Biocatal Agric Biotechnol 14(November 2017):241–253

    Article  Google Scholar 

  • Gong JS et al (2012) Nitrilases in nitrile biocatalysis: recent progress and forthcoming research. Microb Cell Fact 11:142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Griebeler N, Polloni AE, Remonatto D, Arbter F, Vardanega R, Cechet JL, Ninow JL (2011) Isolation and screening of lipase-producing fungi with hydrolytic activity. Food Bioprocess Tech 4(4):578–586

    Article  CAS  Google Scholar 

  • Guedes AC, Amaro HM, Malcata FX (2011) Microalgae as sources of high added-value compounds: a brief review of recent work. Biotechnol Prog 27(3):597–613

    Article  CAS  PubMed  Google Scholar 

  • Gupta RK, Gangoliya SS, Singh NK (2014) Isolation of thermotolerant phytase producing fungi and optimisation of phytase production by Aspergillus niger NRF9 in solid state fermentation using response surface methodology. Biotechnol Bioprocess Eng 19:996–1004

    Article  CAS  Google Scholar 

  • Hassan S, Mathesius U (2012) The role of flavonoids in root-rhizosphere signalling: opportunities and challenges for improving plant-microbe interactions. J Exp Bot 63(9):3429–3444

    Article  CAS  PubMed  Google Scholar 

  • Huang W-Y, Cai Y-Z, Zhang Y (2009) Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 62(1):1–20

    Article  CAS  Google Scholar 

  • Hussain G, Rasul A, Anwar H, Aziz N, Razzaq A, Wei W, Li X (2018) Role of plant derived alkaloids and their mechanism in neurodegenerative disorders. Int J Biol Sci 14(3):341–357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Imran M, Anwar Z, Irshad M, Asad MJ, Ashfaq H (2016) Cellulase production from species of fungi and bacteria from agricultural wastes and its utilization in industry: a review. Adv Enzym Res 4(2):44–55

    Article  CAS  Google Scholar 

  • Ja’afaru MI (2013) Screening of fungi isolated from environmental samples for xylanase and cellulase production. ISRN Microbiol 2013:1–7

    Article  CAS  Google Scholar 

  • Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK (2005) Chemistry and biological activities of C. longa. Trends Food Sci Technol 16(12):533–548

    Article  CAS  Google Scholar 

  • Kakule TB, Lin Z, Schmidt EW (2014) Combinatorialization of fungal polyketide synthase–peptide synthetase hybrid proteins. J Am Chem Soc 136(51):17882–17890

    Google Scholar 

  • Knez Ž, Hrnčič MK, Čolnik M, Škerget M (2017) Chemicals and value added compounds from biomass using sub-and supercritical water. J Supercrit Fluids 133:591–602

    Article  CAS  Google Scholar 

  • Krishnan A, Convey P, Gonzalez-Rocha G, Alias SA (2016) Production of extracellular hydrolase enzymes by fungi from King George Island. Polar Biol 39:65–76

    Article  Google Scholar 

  • Li Y-L, Xin X-M, Chang Z-Y, Shi R-J, Miao Z-M, Ding J, Hao G-P (2015) The endophytic fungi of Salvia miltiorrhiza Bge.f. alba are a potential source of natural antioxidants. Bot Stud 56(1):5

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Liao H, Zheng H, Li S, Wei Z, Mei X, Ma H, Xu Y (2015) Functional diversity and properties of multiple xylanases from Penicillium oxalicum GZ-2. Sci Rep 5(1):12631

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lunardelli Negreiros de Carvalho P, de Oliveira Silva E, Aparecida Chagas-Paula D, Honorata Hortolan Luiz J, Ikegaki M (2016) Importance and implications of the production of phenolic secondary metabolites by endophytic fungi: a mini-review. Mini-Rev Med Chem 16:259–271

    Google Scholar 

  • Ma Y-M, Liang X-A, Kong Y, Jia B (2016) Structural diversity and biological activities of indole diketopiperazine alkaloids from fungi. J Agric Food Chem 64(35):6659–6671

    Article  CAS  PubMed  Google Scholar 

  • Mckelvey MS, Murphy AR (2011) Biotechnological use of fungal enzymes. In: Kavanagh K (ed) Fungi: biology and applications. John Wiley and Sons, Ltd., Chichester, pp 179–202

    Chapter  Google Scholar 

  • Mishra S, Sachan A, Sachan SG (2013) Production of natural value-added compounds: an insight into the eugenol biotransformation pathway. J Ind Microbiol Biotechnol 40(6):545–550

    Article  CAS  PubMed  Google Scholar 

  • Mousa WK, Raizada MN (2013) The diversity of anti-microbial secondary metabolites produced by fungal endophytes: an interdisciplinary perspective. Front Microbiol 4:1–18

    Article  Google Scholar 

  • Nigam P (2013) Microbial enzymes with special characteristics for biotechnological applications. Biomol Ther 3(4):597–611

    Google Scholar 

  • O’Connell JE, Fox PF (2001) Significance and applications of phenolic compounds in the production and quality of milk and dairy products: a review. Int Dairy J 11(3):103–120

    Article  Google Scholar 

  • Oliveira LL, Carvalho MV, Melo L (2014) Health promoting and sensory properties of phenolic compounds in food. Rev Ceres 61(suppl):764–779

    Article  Google Scholar 

  • Pan F, Su T-J, Cai S-M, Wu W (2017) Fungal endophyte-derived Fritillaria unibracteata var. wabuensis: diversity, antioxidant capacities in vitro and relations to phenolic, flavonoid or saponin compounds. Sci Rep 7(1):42008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pandey SS, Singh S, Babu CSV, Shanker K, Srivastava NK, Shukla AK, Kalra A (2016) Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis. Sci Rep 6(1):26583

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patel K, Gadewar M, Tripathi R, Prasad S, Patel DK (2012) A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pac J Trop Biomed 2(8):660–664

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Paulino BN, Pessôa MG, Molina G, Neto AAK, Oliveira JV, Mano MC, Pastore GM (2017) Biotechnological production of value-added compounds by ustilaginomycetous yeasts. Appl Microbiol Biotechnol 101(21):7789–7809

    Article  CAS  PubMed  Google Scholar 

  • Payne CM, Knott BC, Mayes HB, Hansson H, Himmel ME, Sandgren M, Beckham GT (2015) Fungal cellulases. Chem Rev 115(3):1308–1448

    Article  CAS  PubMed  Google Scholar 

  • Pereira MG, Vici AC, Facchini FDA, Tristão AP, Cursino-Santos JR, Sanches PR, Polizeli MDLTDM (2014) Screening of filamentous fungi for lipase production: Hypocrea pseudokoningii, a new producer with a high biotechnological potential. Biocatal Biotransformation 32(1):74–83

    Article  CAS  Google Scholar 

  • Perviz S, Khan H, Pervaiz A (2016) Plant alkaloids as an emerging therapeutic alternative for the treatment of depression. Front Pharmacol 7:1–7

    Article  CAS  Google Scholar 

  • Pooja U, Shrivastava R, Agrawal PK (2016) Bioprospecting and biotechnological applications of fungal laccase. 3. Biotechnology 6:15

    Google Scholar 

  • Qiu M, Xie R, Shi Y, Zhang H, Chen H (2010) Isolation and identification of two flavonoid-producing endophytic fungi from Ginkgo biloba L. Ann Microbiol 60(1):143–150

    Article  CAS  Google Scholar 

  • Quang TH, Kim DC, Van Kiem P, Van Minh C, Nhiem NX, Tai BH, Oh H (2018) Macrolide and phenolic metabolites from the marine-derived fungus Paraconiothyrium sp. VK-13 with anti-inflammatory activity. J Antibiot (Tokyo) 81:5–9

    Google Scholar 

  • Ramawat KG, Mérillon JM (2013) Natural products. In: Ramawat KG, Mérillon J-M (eds) Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Berlin, Heidelberg: Springer

    Google Scholar 

  • Rana KL, Kour D, Sheikh I, Yadav N, Yadav AN, Kumar V, Singh BP, Dhaliwal HS, Saxena AK (2018a) Biodiversity of endophytic fungi from diverse niches and their biotechnological applications. In: Singh BP (ed) Advances in endophytic fungal research. Springer, Cham. https://doi.org/10.1007/978-3-030-03589-1_6

    Chapter  Google Scholar 

  • Rana KL, Kour D, Yadav AN (2018b) Endophytic microbiomes: biodiversity, ecological significance and biotechnological applications. Res J Biotechnol 14:1–30

    Google Scholar 

  • Sakthiselvan P, Naveena B, Partha N (2014) Molecular characterization of a xylanase-producing fungus isolated from fouled soil. Braz J Microbiol 45(4):1293–1302

    Article  CAS  PubMed  Google Scholar 

  • Saleem A, Ebrahim MKH (2014) Production of amylase by fungi isolated from legume seeds collected in Almadinah Almunawwarah, Saudi Arabia. J Taibah Univ Sci 8(2):90–97

    Article  Google Scholar 

  • Savitha S, Sadhasivam S, Swaminathan K, Lin FH (2011) Fungal protease: production, purification and compatibility with laundry detergents and their wash performance. J Taiwan Inst Chem Eng 42(2):298–304

    Article  CAS  Google Scholar 

  • Scervino JM, Ponce MA, Erra-Bassells R, Vierheilig H, Ocampo JA, Godeas A (2005) Flavonoids exhibit fungal species and genus specific effects on the presymbiotic growth of Gigaspora and Glomus. Mycol Res 109(7):789–794

    Article  CAS  PubMed  Google Scholar 

  • Shrivastava G, Ownley BH, Augé RM, Toler H, Dee M, Vu A, Chen F (2015) Colonization by arbuscular mycorrhizal and endophytic fungi enhanced terpene production in tomato plants and their defense against a herbivorous insect. Symbiosis 65(2):65–74

    Article  CAS  Google Scholar 

  • Singh AK, Mukhopadhyay M (2012) Overview of fungal lipase: a review. Appl Biochem Biotechnol 166(2):486–520

    Article  CAS  PubMed  Google Scholar 

  • Singh B, Sharma RA (2015) Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications. 3 Biotech 5(2):129–151

    Article  PubMed  Google Scholar 

  • Singh S, Singh S, Bali V, Sharma L, Mangla J (2014) Production of fungal amylases using cheap, readily available agriresidues, for potential application in textile industry. Biomed Res Int 2014:1–9

    Google Scholar 

  • Souza PMD, Bittencourt MLDA, Caprara CC, Freitas MD, Almeida RPCD, Silveira D, Magalhães PO (2015) A biotechnology perspective of fungal proteases. Braz J Microbiol 46(2):337–346

    Article  PubMed  PubMed Central  Google Scholar 

  • Srivastava N, Srivastava M, Mishra PK, Gupta VK, Molina G, Rodriguez-Couto S, Ramteke PW (2018) Applications of fungal cellulases in biofuel production: advances and limitations. Renew Sustain Energy Rev 82(August):2379–2386

    Article  CAS  Google Scholar 

  • Suman A, Yadav AN, Verma P (2016) Endophytic microbes in crops: diversity and beneficial impact for sustainable agriculture. In: Singh D, Abhilash P, Prabha R (eds) Microbial inoculants in sustainable agricultural productivity: research perspectives. Springer-Verlag, India, pp 117–143. https://doi.org/10.1007/978-81-322-2647-5_7

    Chapter  Google Scholar 

  • Sunitha VH, Ramesha A, Savitha J, Srinivas C (2012) Amylase production by endophytic fungi Cylindrocephalum sp. isolated from medicinal plant Alpinia calcarata (Haw.) Roscoe. Braz J Microbiol 43(3):1213–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tabatabaei M, Karimi K, Sárvári Horváth I, Kumar R (2015) Recent trends in biodiesel production. Biofuel Res J 2(3):258–267

    Article  CAS  Google Scholar 

  • Venkata Subhash G, Venkata Mohan S (2011) Biodiesel production from isolated oleaginous fungi Aspergillus sp. using corncob waste liquor as a substrate. Bioresour Technol 102(19):9286–9290

    Article  CAS  PubMed  Google Scholar 

  • Vicente G, Bautista LF, Rodríguez R, Gutiérrez FJ, Sádaba I, Ruiz-Vázquez RM, Garre V (2009) Biodiesel production from biomass of an oleaginous fungus. Biochem Eng J 48(1):22–27

    Article  CAS  Google Scholar 

  • Wang Y, Gao BL, Li XX, Zhang ZB, Yan RM, Yang HL, Zhu D (2015) Phylogenetic diversity of culturable endophytic fungi in Dongxiang wild rice (Oryza rufipogon Griff), detection of polyketide synthase gene and their antagonistic activity analysis. Fungal Biol 119(11):1032–1045

    Article  CAS  PubMed  Google Scholar 

  • Wu C, Zhao Y, Chen R, Liu D, Liu M, Proksch P, Lin W (2016a) Phenolic metabolites from mangrove-associated Penicillium pinophilum fungus with lipid-lowering effects. RSC Adv 6(26):21969–21978

    Article  CAS  Google Scholar 

  • Wu W, Tran W, Taatjes CA, Alonso-Gutierrez J, Lee TS, Gladden JM (2016b) Rapid discovery and functional characterization of terpene synthases from four endophytic Xylariaceae. PLoS One 11(2):e0146983

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xu W, Gavia DJ, Tang Y (2014) Biosynthesis of fungal indole alkaloids. Nat Prod Rep 31(10):1474–1487

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yadav AN, Sachan SG, Verma P, Kaushik R, Saxena AK (2016) Cold active hydrolytic enzymes production by psychotrophic bacilli isolated from three sub-glacial lakes of NW Indian Himalayas. J Basic Microbiol 56:294–307

    Article  CAS  PubMed  Google Scholar 

  • Yadav AN, Kumar R, Kumar S, Kumar V, Sugitha T, Singh B, Chauhan VS, Dhaliwal HS, Saxena AK (2017a) Beneficial microbiomes: biodiversity and potential biotechnological applications for sustainable agriculture and human health. J Appl Biol Biotechnol 5:1–13

    Article  Google Scholar 

  • Yadav AN, Verma P, Sachan SG, Saxena AK (2017b) Biodiversity and biotechnological applications of psychrotrophic microbes isolated from Indian Himalayan regions. EC Microbiol ECO 1:48–54

    Google Scholar 

  • Yan C, Liu W, Li J, Deng Y, Chen S, Liu H (2018) Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2. RSC Adv 8(27):14823–14828

    Article  CAS  Google Scholar 

  • Yike I (2011) Fungal proteases and their pathophysiological effects. Mycopathologia 171(5):299–323

    Article  CAS  PubMed  Google Scholar 

  • Yopi, Tasia W, Melliawati R (2017) Cellulase and xylanase production from three isolates of indigenous endophytic fungi. IOP Conf Ser Earth Environ Sci 101(1):012035

    Article  Google Scholar 

  • Yu H, Zhang L, Li L, Zheng C, Guo L, Li W, Qin L (2010) Recent developments and future prospects of antimicrobial metabolites produced by endophytes. Microbiol Res 165(6):437–449

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to Pondicherry University for its support in providing the facility to access the different international journals for the successful completion of this chapter.

Author information

Authors and Affiliations

  1. Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India

    Paramanantham Parasuraman & Busi Siddhardha

Authors
  1. Paramanantham Parasuraman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Busi Siddhardha
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, Sirmour, Himachal Pradesh, India

    Ajar Nath Yadav

  2. Dr. Ram Manohar Lohia Avadh University, Faizabad, Uttar Pradesh, India

    Sangram Singh

  3. Biotechnology, Biotech Park, Lucknow, Uttar Pradesh, India

    Shashank Mishra

  4. Department of Zoology, Dr. Ram Manohar Lohia Avadh University, Gonda, Uttar Pradesh, India

    Arti Gupta

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Parasuraman, P., Siddhardha, B. (2019). Natural Value-Added Compounds from Fungal Communities. In: Yadav, A., Singh, S., Mishra, S., Gupta, A. (eds) Recent Advancement in White Biotechnology Through Fungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-14846-1_6

Download citation

Publish with us

Policies and ethics

Search

Navigation