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Histone Methylome of the Human Parasite Schistosoma Mansoni

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The DNA, RNA, and Histone Methylomes

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

The trematode Schistosoma mansoni belongs to the group of digenetic parasites which need obligatory multiple hosts to develop. They transit between hosts as free-swimming stages in fresh water ecosystems. They generate phenotypically different developmental stages throughout their lifecycle and receive hugly heterogenous environmental cues. Each developmental stage is characterized by specific posttranslational histone modifications, in particular methylations. The combination of the different marks result in stage specific chromatin structure that is essential for development, sexual biology and pathogenesis. Histone methylation also responds to environmental changes and seems to be involved in an adaptive reponse or adjustment to the environment. Histone methylation thus represent promising source of therapeutic targets. In this chapter we will present the state-of-the-art of how the dynamics of histone methylation are involved in multiple factors of the schistosome’s development, as well as what is still lacking for better understanding it.

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Authors and Affiliations

  1. University of Montpellier, Montpellier, France

    Ronaldo de Carvalho Augusto, Céline Cosseau & Christoph Grunau

  2. CNRS, Perpignan, France

    Ronaldo de Carvalho Augusto, Céline Cosseau & Christoph Grunau

  3. IFremer, Montpellier, France

    Ronaldo de Carvalho Augusto, Céline Cosseau & Christoph Grunau

  4. University of Perpignan Via Domitia, Perpignan, France

    Ronaldo de Carvalho Augusto, Céline Cosseau & Christoph Grunau

Authors
  1. Ronaldo de Carvalho Augusto
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  2. Céline Cosseau
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  3. Christoph Grunau
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Editor information

Editors and Affiliations

  1. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  2. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Jan Barciszewski

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Augusto, R.d.C., Cosseau, C., Grunau, C. (2019). Histone Methylome of the Human Parasite Schistosoma Mansoni . In: Jurga, S., Barciszewski, J. (eds) The DNA, RNA, and Histone Methylomes. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-14792-1_24

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