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Structural Insights into Rotavirus Entry

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Physical Virology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1215))

Abstract

To initiate infection, non-enveloped viruses must recognize a target cell and penetrate the cell membrane by pore formation or membrane lysis. Rotaviruses are non-enveloped dsRNA viruses that infect the mature intestinal epithelium. They are major etiologic agents of diarrheal disease in human infants, as well as in young individuals of various avian and mammalian species. Rotavirus entry into the cell is a complex multistep process initiated by the interaction of the tip of the viral spike with glycan ligands at the cell surface, and driven by conformational changes of the proteins present in the outer protein capsid, the viral machinery for entry. This review feeds on the abundant structural information produced for rotavirus during the past 30 years and focuses on the structure and the dynamics of the rotavirus entry machinery. We survey the current models for rotavirus entry into cells.

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  1. Centro Nacional de Microbiología/ISCIII, Madrid, Spain

    Javier M. Rodríguez & Daniel Luque

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  1. Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

    Urs F. Greber

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Rodríguez, J.M., Luque, D. (2019). Structural Insights into Rotavirus Entry. In: Greber, U. (eds) Physical Virology. Advances in Experimental Medicine and Biology, vol 1215. Springer, Cham. https://doi.org/10.1007/978-3-030-14741-9_3

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