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Heterogeneity of Small Cell Lung Cancer Stem Cells

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Stem Cells Heterogeneity in Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1139))

Abstract

Small cell lung cancer, a subtype of lung cancer is an extremely malignant disease due to its metastases and recurrence. Patients with SCLC develop resistance to chemotherapy and the disease relapses. This relapse and resistance are attributed to the heterogeneity of SCLC. Various factors such as recurrent mutations in key regulatory genes such as TP53, RB1, and myc, epigenetic changes, and cancer stem cells contribute to the observed heterogeneity. Cancer stem cell models predict neuroendocrine origin of SCLC. Though an unambiguous established CSC marker has not been assigned, markers CD133, CD44 have been found associated with SCLC. Genetically engineered mouse models (GEMMs) allow the validation of driver mutations and are necessary for design of targeted therapy. This chapter outlines the factors contributing to SCLC heterogeneity, detection methods, and the current therapy trials.

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Author information

Authors and Affiliations

  1. Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India

    D. Prabavathy

  2. Department of Biology, California State University Northridge, Northridge, CA, USA

    Niveditha Ramadoss

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  1. D. Prabavathy
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  2. Niveditha Ramadoss
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Editor information

Editors and Affiliations

  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, MG, Brazil

    Alexander Birbrair

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Prabavathy, D., Ramadoss, N. (2019). Heterogeneity of Small Cell Lung Cancer Stem Cells. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Cancer. Advances in Experimental Medicine and Biology, vol 1139. Springer, Cham. https://doi.org/10.1007/978-3-030-14366-4_3

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