Abstract
Neoadjuvant therapy consists of the preoperative administration of systemic treatment in patients with nonmetastatic breast cancer (BC). The term neoadjuvant chemotherapy (neoChT) does not adequately reflect the wide range of possibilities for systemic treatment that can be employed in this setting—such as endocrine therapy and new target therapies—being “technically more appropriate” to use neoadjuvant systemic therapy (NST); see Table 1.
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Buzdar AU, Valero V, Ibrahim NK, et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res. 2007;13(1):228–33. A small randomized institutional study showing that the addition of trastuzumab to neoChT elevates pCR to the expressive rate of 60%. Although trastuzumab was administered concomitantly throughout ChT (including anthracycline), there was no apparent increase in cardiotoxicity.
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Mano, M.S., Linck, R.D.M. (2019). Neoadjuvant Therapies. In: Novita, G., Frasson, A., Millen, E., Zerwes, F., Cavalcante, F. (eds) Breast Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-13636-9_61
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DOI: https://doi.org/10.1007/978-3-030-13636-9_61
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