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Hypoxia and the Tumor Secretome

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Hypoxia and Cancer Metastasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1136))

Abstract

Metastasis remains the leading cause of cancer-related deaths. To date, there are no specific treatments targeting disseminated disease. New therapeutic options will become available only if we enhance our understanding of mechanisms underlying metastatic spread. A large body of literature shows that the metastatic potential of tumor cells is strongly influenced by microenvironmental cues such as low oxygen (hypoxia). Clinically, hypoxia is a hallmark of most solid tumors and is associated with increased metastasis and poor survival in a variety of cancer types. Mechanistically, hypoxia influences multiple steps within the metastatic cascade and particularly impacts the interactions between tumor cells and host stroma at both primary and secondary sites. Here we review current evidence for a hypoxia-induced tumor secretome and its impact on metastatic progression. These studies have identified potential biomarkers and therapeutic targets that could be integrated into strategies for preventing and treating metastatic disease.

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Acknowledgments

This work was supported by NIH Grant 1U54CA210173-01. We apologize to other researchers whose work we could not cite owing to space constraints.

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Authors and Affiliations

  1. The Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Ying Liu, Gabrielle E. Ciotti & T. S. Karin Eisinger-Mathason

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  1. Ying Liu
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  2. Gabrielle E. Ciotti
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  3. T. S. Karin Eisinger-Mathason
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Correspondence to T. S. Karin Eisinger-Mathason .

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Editors and Affiliations

  1. Breast and Ovarian Cancer Program, Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Daniele M. Gilkes

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Liu, Y., Ciotti, G.E., Eisinger-Mathason, T.S.K. (2019). Hypoxia and the Tumor Secretome. In: Gilkes, D. (eds) Hypoxia and Cancer Metastasis. Advances in Experimental Medicine and Biology, vol 1136. Springer, Cham. https://doi.org/10.1007/978-3-030-12734-3_4

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