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Hypoxia Mediates Tumor Malignancy and Therapy Resistance

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Hypoxia and Cancer Metastasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1136))

Abstract

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and controls hypoxia-mediated pathological processes in tumors, including angiogenesis, metabolic reprogramming, epigenetic reprogramming, immune evasion, pH homeostasis, cell migration/invasion, stem cell pluripotency, and therapy resistance. In this book chapter, we reviewed the causes and types of intratumoral hypoxia, hypoxia detection methods, and the oncogenic role of HIF in tumorigenesis and chemo- and radio-therapy resistance.

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Acknowledgments

Work in authors’ laboratories was supported by grants from NIH (R00CA168746), CPRIT (RR140036), Susan G. Komen® (CCR16376227), Welch Foundation (I-1903-20160319), and American Cancer Society and UTSW Simmons Cancer Center (ACS-IRG-02-196) to W.L.; and NIH (R00NS078049, R35GM124693), Welch Foundation (I-1939-20170325), CPRIT (RP170671), Darrell K Royal Research Fund, TIBIR pilot grant, and UTSW startup funds to Y.W.. W.L. is a CPRIT Scholar in Cancer Research.

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Authors and Affiliations

  1. Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA

    Weibo Luo & Yingfei Wang

  2. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA

    Weibo Luo

  3. Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA

    Yingfei Wang

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  1. Weibo Luo
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  2. Yingfei Wang
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Correspondence to Weibo Luo or Yingfei Wang .

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  1. Breast and Ovarian Cancer Program, Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Daniele M. Gilkes

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Luo, W., Wang, Y. (2019). Hypoxia Mediates Tumor Malignancy and Therapy Resistance. In: Gilkes, D. (eds) Hypoxia and Cancer Metastasis. Advances in Experimental Medicine and Biology, vol 1136. Springer, Cham. https://doi.org/10.1007/978-3-030-12734-3_1

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