Abstract
Nanoscience has flourished with increasing use of nanoparticles in many products. The particles enter the environment and affect both biotic and abiotic components of the ecosystem. Via the water supply and the food chain, humans could be affected by ingesting those particles. In this chapter, we will discuss mechanisms by which nanoparticles or their constituents can be translocated from the gastrointestinal tract, what their fate may be and how relevant this is for human health.
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Piccinno, F., Gottschalk, F., Seeger, S., Nowack, B.: Industrial production quantities and uses of ten engineered nanomaterials in Europe and the world. J. Nanopart. Res. 14, 1109 (2012). https://doi.org/10.1007/s11051-012-1109-9
Ostiguy, C., Roberge, B., Woods, C., Soucy, B.: Engineered Nanoparticles: Current Knowledge about OHS Risks and Prevention Measures, 2nd edn. Institut de recherche Robert-Sauvé en santé et en sécurité du travail (2010). ISBN 2896314792, 9782896314799. https://www.irsst.qc.ca/en/publications-tools/publication/i/100529/n/engineered-nanoparticles-current-knowledge-about-occupational-health-and-safety-risks-and-prevention-measures-second-edition-r-656/redirected/1
Griffin, S., Masood, M.I., Nasim, M.J., Sarfraz, M., Ebokaiwe, A.P., Schäfer, K.-H., Keck, C.M., Jacob, C.: Natural nanoparticles: a particular matter inspired by Nature. Antioxidants 7, 3 (2018). https://doi.org/10.3390/antiox7010003
Boccuni, F., Ferrante, R., Tombolini, F., Lega, D., Antonini, A., Alvino, A., Pingue, P., Beltram, F., Sorba, L., Piazza, V., Gemmi, M., Porcari, A., Iavicoli, S.: Workers’ exposure to nano-objects with different dimensionalities in R&D laboratories: measurement strategy and field studies. Int. J. Mol. Sci. 19, 349–377 (2018). https://doi.org/10.3390/ijms19020349
Kirch, J., Guenther, M., Doshi, N., Schaefer, U.F., Schneider, M., Mitragotri, S., Lehr, C.-M.: Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge—an ex vivo and in silico approach. J. Control Rel. 159, 128–134 (2012). https://doi.org/10.1016/j.jconrel.2011.12.015
Pan, K., Zhong, Q.: Organic nanoparticles in foods: fabrication, characterization and utilization. Annu. Rev. Food Sci. Technol. 7, 245–266 (2016). https://doi.org/10.1146/annurev-food-041715-033215
Sekhon, B.S.: Food nanotechnology—an overview. Nanotechnol. Sci. Appl. 3, 1–15 (2010). https://doi.org/10.2147/NSA.S8677
Herbst, E.F.G.: Das Lymphgefäßsystem und seine Verrichtungen, pp. 333–337, Göttingen (1844)
Hirsch, R.: Über das Vorkommen von Stärkekörnern im Blut und im Urin. Z. Exp. Path. Ther. 3, 390 (1906)
Volkheimer, G.: Detection of starch in tissue and urine after oral starch intake. Dtsch Gesundheitsw 15, 1298–1302 (1960)
Jani, P.U., Florence, A.T., McCarthy, D.E.: Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat. Int. J. Pharm. 84, 245–252 (1992). https://doi.org/10.1016/0378-5173(92)90162-U
Alpar, H.O., Field, W.N., Hyde, R., Lewis, D.A.: The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat. J. Pharm. Pharmacol. 41, 194–196 (1989). https://doi.org/10.1111/j.2042-7158.1989.tb06429.x
Payne, J.M., Sansom, B.F., Garner, R.J., Thomson, A.R., Miles, B.J.: Uptake of small resin particles (1-5 µ diameter) by the alimentary canal of the calf. Nature 188, 586–587 (1960). https://doi.org/10.1038/188586a0
Pontefract, R.D., Cunningham, H.M.: Penetration of asbestos through the digestive tract of rats. Nature 243, 352–353 (1973). https://doi.org/10.1038/243352a0
Sanders, E., Ashworth, C.T.: A study of particulate intestinal absorption and hepatocellular uptake: Use of polystyrene latex particle. Exp. Cell Res. 22, 137–145 (1961). https://doi.org/10.1016/0014-4827(61)90092-1
Hodges, G.M., Carr, E.A., Hazzard, R.A., O’Reilly, C., Carr, K.E.: A commentary on morphological and quantitative aspects of microparticle translocation across the gastrointestinal mucosa. J. Drug Target. 3, 57–60 (1995). https://doi.org/10.3109/10611869509015934
Ebel, J.P.: A method for quantifying particle absorption from the small intestine of the mouse. Pharm. Res. 7, 848–851 (1990). https://doi.org/10.1023/A:1015964916486
Limpanussorn, J., Simon, L., Dayan, A.D.D.: Transepithelial transport of large particles in rat: a new model for the quantitative study of particle uptake. J. Pharm. Pharmacol. 50, 753–760 (1998). https://doi.org/10.1111/j.2042-7158.1998.tb07136.x
Powell, J.J., Faria, N., Thomas-McKay, E., Pele, L.C.: Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J. Autoimmun. 34, J226–J233 (2010). https://doi.org/10.1016/j.jaut.2009.11.006
Fröhlich, E., Mercuri, A., Wu, S., Salar-Behzadi, S.: Measurements of deposition, lung surface area and lung fluid for simulation of inhaled compounds. Front. Pharmacol. 7, 181 (2016). https://doi.org/10.3389/fphar.2016.00181
Squier, C.A., Kremer, M.J.: Biology of oral mucosa and esophagus. J. Natl. Cancer Inst. Monogr. 29, 7–15 (2001). https://doi.org/10.1093/oxfordjournals.jncimonographs.a003443
Squier, C.A.: The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidase. J. Ultrastruct. Res. 43, 160–177 (1973). https://doi.org/10.1016/S0022-5320(73)90076-2
Squier, C.A.: The permeability of oral mucosa. Crit. Rev. Oral Biol. Med. 2, 13–32 (1991)
Ramaker, K., Bade, S., Röckendorf, N., Meckelein, B., Vollmer, E., Schulz, H., Fröschle, G.-W., Frey, A.: Absence of the epithelial glycocalyx as potential tumor marker for the early detection of colorectal cancer. PLoS ONE 11, e0168801 (2016). https://doi.org/10.1371/journal.pone.0168801
Bullen, T.F., Forrest, S., Campbell, F., Dodson, A.R., Hershman, M.J., Pritchard, D.M., Turner, J.R., Montrose, M.H., Watson, A.J.M.: Characterization of epithelial cell shedding from human small intestine. Lab. Invest. 86, 1052–1063 (2006). https://doi.org/10.1038/labinvest.3700464
Madara, J.L.: Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions. J. Mem. Biol. 116, 177–184 (1990)
Marchiando, A.M., Shen, L., Graham, W.V., Edelblum, K.L., Duckworth, C.A., Guan, Y., Montrose, M.H., Turner, J.R., Watson, A.J.M.: The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 140, 1208–1218 (2011). https://doi.org/10.1053/j.gastro.2011.01.004
Watson, A.J.M., Chu, S., Sieck, L., Gerasimenko, O., Bullen, T., Campbell, F., McKenna, M., Rose, T., Montrose, M.H.: Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129, 902–912 (2005). https://doi.org/10.1053/j.gastro.2005.06.015
Frey, A., Giannasca, K.T., Weltzin, R., Giannasca, P.J., Reggio, H., Lencer, W.I., Neutra, M.R.: Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J. Exp. Med. 184, 1045–1059 (1996). https://doi.org/10.1084/jem.184.3.1045
Pelasayed, T., Bergström, J.H., Gustafsson, J.K., Ermund, A., Birchenough, G.M.H., Schütte, A., van der Post, S., Svensson, F., Rodríguez-Piñeiro, A.M., Nyström, E.E.L., Wising, C., Johansson, M.E.V., Hansson, G.C.: The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev. 260, 8–20 (2014). https://doi.org/10.1111/imr.12182
Johansson, M.E.V., Sjövall, H., Hansson, G.C.: The gastrointestinal mucus system in health and disease. Nat. Rev. Gastroenterol. Hepatol. 10, 352–361 (2013). https://doi.org/10.1038/nrgastro.2013.35
Neutra, M.R., Forstner, J.F.: Gastrointestinal mucus: synthesis, secretion, and function. In: Johnson, L.R. (ed.) Physiology of the Gastrointestinal Tract. Raven Press: New York, NY, U.S.A, (1987)
Johansson, M.E.V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., Hansson, G.C.: The inner of the two MUC2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. U.S.A. 105, 15064–15069 (2008). https://doi.org/10.1073/pnas.0803124105
Busch, A.E., Herzer, T., Waldegger, S., Schmidt, F., Palacin, M., Biber, J., Markovich, D., Murer, H., Lang, F.: Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oocytes expressing the protein rBAT. J. Biol. Chem. 269, 25581–25586 (1994)
Palacín, M., Kanai, Y.: The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflugers Arch. Eur. J. Physiol. 447, 490–494 (2004). https://doi.org/10.1007/s00424-003-1062-7
Howard, A., Hirst, B.H.: The glycine transporter GLYT1 in human intestine: expression and function. Biol. Pharm. Bull. 34, 784–788 (2011). https://doi.org/10.1248/bpb.34.784
Pramod, A.B., Foster, J., Carvelli, L., Henry, L.K.: SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol. Asp. Med. 34, 197–219 (2013). https://doi.org/10.1016/j.mam.2012.07.002
Bröer, A., Klingel, K., Kowalczuk, S., Rasko, J.E.J., Cavanaugh, J., Bröer, S.: Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup Disorder. J. Biol. Chem. 279, 24467–24476 (2004). https://doi.org/10.1074/jbc.M400904200
Takanaga, H., Mackenzie, B., Suzuki, Y., Hediger, M.A.: Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical System Imino. J. Biol. Chem. 280, 8974–8984 (2005). https://doi.org/10.1074/jbc.M413027200
Thwaites, D.T., Anderson, C.M.H.: The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. Br. J. Pharmacol. 164, 1802–1816 (2011). https://doi.org/10.1111/j.1476-5381.2011.01438.x
Douard, V., Ferraris, R.P.: Regulation of the fructose transporter GLUT5 in health and disease. Am. J. Physiol. 295, E227–E237 (2008). https://doi.org/10.1152/ajpendo.90245.2008
Wright, E.M.: Glucose transport families SLC5 and SLC50. Mol. Asp. Med. 34, 183–196 (2013). https://doi.org/10.1016/j.mam.2012.11.002
Wright, E.M., Turk, E.: The sodium/glucose cotransport family SLC5. Pflugers Arch. Eur. J. Physiol. 447, 510–518 (2004). https://doi.org/10.1007/s00424-003-1063-6
Barley, N.F., Howard, A., O’Callaghan, D., Legon, S., Walters, J.R.F.: Epithelial calcium transporter expression in human duodenum. Am. J. Physiol. 280, G285–G290 (2001). https://doi.org/10.1152/ajpgi.2001.280.2.G285
Vesey, D.A.: Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals. Toxicol. Lett. 198, 13–19 (2010). https://doi.org/10.1016/j.toxlet.2010.05.004
Mackenzie, B., Hediger, M.A.: SLC11 family of H + -coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch. Eur. J. Physiol. 447, 571–579 (2004). https://doi.org/10.1007/s00424-003-1141-9
Hashimoto, A., Kambe, T.: Mg, Zn and Cu transport proteins: a brief overview from physiological and molecular perspectives. J. Nutr. Sci. Vitaminol. 61, S116–S118 (2015). https://doi.org/10.3177/jnsv.61.S116
Voets, T., Nilius, B., Hoefs, S., van der Kemp, A.W.C.M., Droogmans, G., Bindels, R.J.M., Hoenderop, J.G.J.: TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J. Biol. Chem. 279, 19–25 (2004). https://doi.org/10.1074/jbc.M311201200
Reboul, E.: Vitamin E bioavailability: mechanisms of intestinal absorption in the spotlight. Antioxidants 6, 95 (2017). https://doi.org/10.3390/antiox6040095
Reboul, E., Borel, P.: Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mamalian enterocytes. Prog. Lipid Res. 50, 388–402 (2011). https://doi.org/10.1016/j.plipres.2011.07.001
Anderson, C.M., Stahl, A.: SLC27 fatty acid transport proteins. Mol. Asp. Med. 34, 516–528 (2013). https://doi.org/10.1016/j.mam.2012.07.010
Daniel, H., Kottra, G.: The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. Eur. J. Physiol. 447, 610–618 (2004). https://doi.org/10.1007/s00424-003-1101-4
May, J.M.: The SLC23 family of ascorbate transportes: ensuring that you get and keep your daily dose of vitamin C. Br. J. Pharmacol. 164, 1793–1801 (2011). https://doi.org/10.1111/j.1476-5381.2011.01350.x
Yonezawa, A., Inui, K.: Novel riboflavin transporter family RFVT/SLC52: identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol. Asp. Med. 34, 693–701 (2013). https://doi.org/10.1016/j.mam.2012.07.014
Zhao, R., Goldman, I.D.: Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol. Asp. Med. 34, 373–385 (2013). https://doi.org/10.1016/j.mam.2012.07.006
Ganapathy, V., Smith, S.B., Prasad, P.D.: SLC19: the folate/thiamine transporter family. Pflugers Arch. Eur. J. Physiol. 447, 641–646 (2004). https://doi.org/10.1007/s00424-003-1068-1
Roth, M., Obaidat, A., Hagenbuch, B.: OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Brit. J. Pharmacol. 165, 1260–1287 (2012). https://doi.org/10.1111/j.1476-5381.2011.01724.x
Bargheer, D., Giemsa, A., Freund, B., Heine, M., Waurisch, C., Stachowski, G.M., Hickey, S.G., Eychmüller, A., Heeren, J., Nielsen, P.: The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice. Beilstein J. Nanotechnol. 6, 111–123 (2015). https://doi.org/10.3762/bjnano.6.11
Heinrich, H.C.: Diagnostik, Ätiologie und Therapie des Eisenmangels unter besonderer Berücksichtigung der 59Fe-Retentionsmessung im Gesamtkörper-Radioaktivitätsdetektor. Der Nuklearmediziner 137, 137–269 (1983)
Bruns, O.T., Ittrich, H., Peldschus, K., Kaul, M.G., Tromsdorf, U.I., Lauterwasser, J., Nikolic, M.S., Mollwitz, B., Merkel, M., Bigall, N.C., Sapra, S., Reimer, R., Hohenberg, H., Weller, H., Eychmüller, A., Adam, G., Beisiegel, U., Heeren, J.: Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. Nat. Nanotechnol. 4, 193–201 (2009). https://doi.org/10.1038/nnano.2008.405
Kottwitz, K., Laschinsky, N., Fischer, R., Nielsen, P.: Absorption, excretion and retention of 51Cr from labelled Cr-(III)-picolinate in rats. Biometals 22, 289–295 (2009). https://doi.org/10.1007/s10534-008-9165-4
Chen, N., He, Y., Su, Y., Li, X., Huang, Q., Wang, H., Zhang, X., Tai, R., Fan, C.: The cytotoxicity of cadmium-based quantum dots. Biomaterials 33, 1238–1244 (2012). https://doi.org/10.1016/j.biomaterials.2011.10.070
Cho, S.J., Maysinger, D., Jain, M., Röder, B., Hackbarth, S., Winnik, F.M.: Long-term exposure of CdTe quantum dots causes functional impairments in live cells. Langmuir 23, 1974–1980 (2007). https://doi.org/10.1021/la060093j
Hardman, R.: A toxicological review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 114, 165–172 (2006). https://doi.org/10.1289/ehp.8284
Hoshino, A., Hanada, S., Yamamoto, K.: Toxicity of nanocrystal quantum dots: the relevance of surface modifications. Arch. Toxicol. 85, 707–720 (2011). https://doi.org/10.1007/s00204-011-0695-0
Winnik, F.M., Maysinger, D.: Quantum dot cytotoxicity and ways to reduce it. Acc. Chem. Res. 46, 672–680 (2013). https://doi.org/10.1021/ar3000585
Zheng, X., Tian, J., Weng, L., Wu, L., Jin, Q., Zhao, J., Wang, L.: Cytotoxicity of cadmium-containing quantum dots based on a study using a microfluidic chip. Nanotechnology 23, 055102 (2012). https://doi.org/10.1088/0957-4484/23/5/055102
Loginova, Y.F., Dezhurov, S.V., Zherdeva, V.V., Kazachkina, N.I., Wakstein, M.S., Savitsky, A.P.: Biodistribution and stability of CdSe core quantum dots in mouse digestive tract following per os administration: Advantages of double polymer/silica coated nanocrystals. Biochem. Biophys. Res. Commun. 419, 54–59 (2012). https://doi.org/10.1016/j.bbrc.2012.01.123
Mohs, A.M., Duan, H., Kairdolf, B.A., Smith, A.M., Nie, S.: Proton-resistant quantum dots: stability in gastrointestinal fluids and implications for oral delivery of nanoparticle agents. Nano Res. 2, 500–508 (2009). https://doi.org/10.1007/s12274-009-9046-3
Mancini, M.C., Kairdolf, B.A., Smith, A.M., Nie, S.: Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long term fate and toxicity of nanocrystals in-vivo. J. Am. Chem. Soc. 130, 10836–10837 (2008). https://doi.org/10.1021/ja8040477
Smith, A.M., Duan, H., Rhyner, M.N., Ruan, G., Nie, S.: A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Phys. Chem. Chem. Phys. 8, 3895–3903 (2006). https://doi.org/10.1039/b606572b
Min, K.S., Sano, E., Ueda, H., Sakazaki, F., Yamada, K., Takano, M., Tanaka, K.: Dietary deficiency of calcium and/or iron, an age-related risk factor for renal accumulation of cadmium in Mice. Biol. Pharm. Bull. 38, 1557–1563 (2015)
Hauck, T.S., Anderson, R.E., Fischer, H.C., Newbigging, S., Chan, W.C.W.: In vivo quantum-dot toxicity assessment. Small 6, 138–144 (2010). https://doi.org/10.1002/smll.200900626
Rzigalinski, B.A., Strobl, J.S.: Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots. Toxicol. Appl. Pharmacol. 238, 280–288 (2009). https://doi.org/10.1016/j.taap.2009.04.010
Tsoi, K.M., Dai, Q., Alman, B.A., Chan, W.C.: Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. Acc. Chem. Res. 46, 662–671 (2013). https://doi.org/10.1021/ar300040z
Liu, Y., Li, Y., Liu, K., Shen, J.: Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract. PLoS ONE 9, e85323 (2014). https://doi.org/10.1371/journal.pone.0085323
Breton, J., Daniel, C., Dewulf, J., Pothion, S., Froux, N., Sauty, M., Thomas, P., Pot, B., Foligné, B.: Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol. Lett. 222, 132–138 (2013). https://doi.org/10.1016/j.toxlet.2013.07.021
Zhai, Q., Yin, R., Yu, L., Wang, G., Tian, F., Yu, R., Zhao, J., Liu, X., Chen, Y.Q., Zhang, H., Chen, W.: Screening of lactic acid bacteria with potential protective effects against cadmium toxicity. Food Control 54, 23–30 (2015). https://doi.org/10.1016/j.foodcont.2015.01.037
Breton, J., Massart, S., Vandamme, P., De Brandt, E., Pot, B., Foligné, B.: Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome. BMC Pharmacol. Toxicol. 14, 62 (2013). https://doi.org/10.1186/2050-6511-14-62
Tiwari, R., Singh, R.D., Khan, H., Gangopadhyay, S., Mittal, S., Singh, V., Arjaria, N., Shankar, J., Roy, S.K., Singh, D., Srivastava, V.: Oral subchronic exposure to silver nanoparticles causes renal damage through apoptotic impairment and necrotic cell death. Nanotoxicology 11, 671–686 (2017). https://doi.org/10.1080/17435390.2017.1343874
Nielsen, P.: Chelation therapy for heavy metals. In: Crichton, R., Ward, R.J., Hider, R.C., (eds.) Metal Chelation in Medicine. The Royal Society of Chemistry (2016). https://doi.org/10.1039/9781782623892
Lo, D.D.: Vigilance or subversion? Constitutive and inducible M cells in mucosal tissues. Trends Immunol. 39, 185–195 (2017). https://doi.org/10.1016/j.it.2017.09.002
Mantis, N.J., Frey, A., Neutra, M.R.: Accessibility of glycolipid and oligosaccharide epitopes on rabbit villus and follicle-associated epithelium. Am. Physiol. 278, G915–G923 (2000). https://doi.org/10.1152/ajpgi.2000.278.6.G915
Bonnardel, J., Da Silva, C., Henri, S., Tamoutounour, S., Chasson, L., Montaña-Sanchis, F., Gorvel, J.-P., Lelouard, H.: Innate and adaptive immune functions of Peyer’s patch monocyte-derived cells. Cell Rep. 11, 770–784 (2015). https://doi.org/10.1016/j.celrep.2015.03.067
Neutra, M.R., Frey, A., Kraehenbuhl, J.-P.: Epithelial M cells: gateways for mucosal infection and immunization. Cell 86, 345–348 (1996). https://doi.org/10.1016/S0092-8674(00)80106-3
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., Ricciardi-Castagnoli, P.: Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2, 361–367 (2001). https://doi.org/10.1038/86373
Jung, C., Hugot, J.-P., Barreau, F.: Peyer’s patches: the immune sensors of the intestine. Int. J. Inflamm. 2010, 823710 (2010). https://doi.org/10.4061/2010/823710
Knoop, K.A., Kumar, N., Butler, B.R., Sakthivel, S.K., Taylor, R.T., Nochi, T., Akiba, H., Yagita, H., Kiyono, H., Williams, I.R.: RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epitelium. J. Immunol. 183, 5738–5747 (2009). https://doi.org/10.4049/jimmunol.0901563
Kanaya, T., Ohno, H.: The mechanisms of M cell differentiation. Biosci. Microbiota Food Health 33, 91–97 (2014). https://doi.org/10.12938/bmfh.33.91
Jang, M.H., Kweon, M.-N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P.D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., Kiyono, H.: Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. U.S.A 101, 6110–6115 (2004). https://doi.org/10.1073/pnas.0400969101
Lelouard, H., Fallet, M., De Boris, B., Méresse, S., Gorvel, J.-P.: Peyer’s patch dendritic cells sample antigens by extending dendrites through M-cell specific transcellular pores. Gastroenterology 142, 592–601 (2012). https://doi.org/10.1053/j.gastro.2011.11.039
Pelasayed, T., Gustafsson, J.K., Gustafsson, I.J., Ermund, A., Hansson, G.C.: Carbachol-induced MUC-17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am. J. Physiol. 305, C457–C467 (2013). https://doi.org/10.1152/ajpcell.00141.2013
Silveira, J.R., Raymond, G.J., Hughson, A.G., Race, R.E., Sim, V.L., Hayes, S.F., Caughy, B.: The most infectious prion particles. Nature 437, 257–261 (2005). https://doi.org/10.1038/nature03989
Bade, S., Frey, A.: Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies. Expert Rev. Vaccines 6, 153–168 (2007). https://doi.org/10.1586/14760584.6.2.153
Donaldson, D.S., Kobayashi, A., Ohno, H., Yagita, H., Williams, I.R., Mabbott, N.A.: M cell-depletion blocks oral prion disease pathogenesis. Mucosal Immunol. 5, 216–225 (2012). https://doi.org/10.1038/mi.2011.68
Donaldson, D.S., Sehgal, A., Rios, D., Williams, I.R., Mabbott, N.A.: Increased abundance of M cells in the gut epithelium dramatically enhances oral prion disease susceptibility. PLoS Pathog. 12, e1006075 (2016). https://doi.org/10.1371/journal.ppat.1006075
Ermak, T.H., Dougherty, E.P., Bhagat, H.R., Kabok, Z., Papp, J.: Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer’s patch M cells. Cell Tissue Res. 279, 433–436 (1995). https://doi.org/10.1007/BF00318501
Foged, C., Brodin, B., Frokjaer, S., Sundblad, A.: Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int. J. Pharm. 298, 315–322 (2005). https://doi.org/10.1016/j.ijpharm.2005.03.035
Gebert, A., Steinmetz, I., Fassbender, S., Wendlandt, K.-H.: Antigen transport into Peyer’s patches: Increased uptake by constant numbers of M cells. Am. J. Pathol. 164, 65–72 (2004). https://doi.org/10.1016/s0002-9440(10)63097-0
Jepson, M., Simmons, N.L., O’Hagan, D.T., Hirst, B.H.: Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target. 1, 245–249 (1993). https://doi.org/10.3109/10611869308996082
Jepson, M.A., Simmons, N.L., Savidge, T.C., James, P.S., Hirst, B.H.: Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells. Cell Tissue Res. 271, 399–405 (1993). https://doi.org/10.1007/BF02913722
Pappo, J., Ermak, T.H.: Uptake and translocation of fluorescent latex particles by rabbit Peyer’s patch follicle epithelium: a quantitative model for M cell uptake. Clin. Exp. Immunol. 76, 144–148 (1989)
Berg, R.D.: Bacterial translocation from the gastrointestinal tract. Trends Microbiol. 3, 149–154 (1995). https://doi.org/10.1016/S0966-842X(00)88906-4
Gewirtz, A.T., Navas, T.A., Lyons, S., Godowski, P.G., Madara, J.L.: Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167, 1882–1885 (2001). https://doi.org/10.4049/jimmunol.167.4.1882
Husebye, E.: The pathogenesis of gastrointestinal bacterial overgrowth. Chemotherapy 51(Suppl1), 1–22 (2005). https://doi.org/10.1159/000081988
Berkes, J., Viswanathan, V.K., Savkovic, S.D., Hecht, G.: Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52, 439–451 (2003). https://doi.org/10.1136/gut.52.3.439
Mukiza, C.N., Dubreuil, J.D.: Escherichia coli heat-stable toxin b impairs intestinal barrier function by altering tight junction proteins. Infect. Immun. 81, 2819–2827 (2013). https://doi.org/10.1128/IAI.00455-13
Ugalde-Silva, P., Gonzalez-Lugo, O., Navarro-Garcia, F.: Tight junction disruption induced by type 3 secretion system effectors injected by enteropathogenic and enterohemorrhagic Escherichia coli. Front. Cell Infect. Mirobiol. 6, 87 (2016). https://doi.org/10.3389/fcimb.2016.00087
Freeman, H.J.: Spontaneous free perforation of the small intestine in adults. World J. Gastroenterol. 20, 9990–9997 (2014). https://doi.org/10.3748/wjg.v20.i29.9990
Laukoetter, M.G., Nava, P., Nusrat, A.: Role of the intestianal barrier in inflammatory bowel disease. World J. Gastroenterol. 14, 401–407 (2008). https://doi.org/10.3748/wjg.14.401
Schmitz, H., Barmeyer, C., Fromm, M., Runkel, N., Foss, H.-D., Bentzel, C.J., Rieken, E.-O., Schulzke, J.-D.: Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 116, 301–309 (1999). https://doi.org/10.1016/S0016-5085(99)70126-5
Lechuga, S., Ivanov, A.I.: Disruption of the epithelial barrier during intestinal inflammation: quest for new molecules and mechanisms. Biochim. Biophys. Acta 1864, 1183–1194 (2017). https://doi.org/10.1016/j.bbamcr.2017.03.007
Lautenschläger, C., Schmidt, C., Lehr, C.-M., Fischer, D., Stallmach, A.: PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease. Eur. J. Pharm. Biopharm. 85, 578–586 (2013). https://doi.org/10.1016/j.ejpb.2013.09.016
Champion, J.A., Mitragotri, S.: Role of target geometry in phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 103, 4930–4934 (2006). https://doi.org/10.1073/pnas.0600997103
Docter, D., Westmeier, D., Markiewicz, M., Stolte, S., Knauer, S.K., Staubert, R.H.: The nanoparticle biomolecule corona: lessons learned—challenge accepted? Chem. Soc. Rev. 44, 6094–6121 (2015). https://doi.org/10.1039/c5cs00217f
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., Dawson, K.A.: Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc. Natl. Acad. Sci. U.S.A. 105, 14265–14270 (2008). https://doi.org/10.1073/pnas.0805135105
Saptarshi, S.R., Duschi, A., Lopata, A.L.: Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle. J. Nanobiotech. 11, 26 (2013). https://doi.org/10.1186/1477-3155-11-26
Parsons, B.N., Campbell, B.J., Wigley, P.: Soluble plantain nonstarch polysaccharides, although increasing caecal load, reduce systemic invasion of Salmonella gallinarum in the chicken. Lett. Appl. Microbiol. 60, 347–351 (2014). https://doi.org/10.1111/lam.12377
Parsons, B.N., Wigley, P., Simpson, H.L., Williams, J.M., Humphrey, S., Salisbury, A.-M., Watson, A.J.M., Fry, S.C., O’Brien, D., Roberts, C.L., O’Kennedy, N., Keita, A.V., Söderholm, J.D., Rhodes, J.M., Campbell, B.J.: Dietary Supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of Salmonella typhimurium in the chicken. PLoS ONE 9, e87658 (2014). https://doi.org/10.1371/journal.pone.0087658
Roberts, C.L., Keita, A.V., Duncan, S.H., O’Kennedy, N., Söderholm, J.D., Rhodes, J.M., Campbell, B.J.: Translocation of Crohn’s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 59, 1331–1339 (2010). https://doi.org/10.1136/gut.2009.195370
Roberts, C.L., Keita, A.V., Parsons, B.N., Prorok-Hamon, M., Knight, P., Winstanley, C., O’Kennedy, N., Söderholm, J.D., Rhodes, J.M., Campbell, B.J.: Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogens. J. Nutr. Biochem. 24, 97–103 (2013). https://doi.org/10.1016/j.jnutbio.2012.02.013
Hochella Jr., M.F., Spencer, M.G., Jones, K.L.: Nanotechnology: nature’s gift or scientists’ brainchild? Environ. Sci. Nano 2, 114–119 (2015). https://doi.org/10.1039/c4en00145a
Sharma, V.K., Filip, J., Zboril, R., Varma, R.S.: Natural inorganic nanoparticles—formation, fate, and toxicity in the environment. Chem. Soc. Rev. 44, 8410–8423 (2015). https://doi.org/10.1039/c5cs00236b
Griffin, S., Masood, M.I., Nasim, M.J., Sarfraz, M., Ebokaiwe, A.P., Schäfer, K.-H., Keck, C.M., Jacob, C.: Natural nanoparticles: a particular matter inspired by Nature. Antioxidants 7, 3 (2018). https://doi.org/10.3390/antiox7010003
Strambeanu, N., Demetrovici, L., Dragos, D.: Natural sources of nanoparticles. In: Lungu, M. et al. (eds.) Nanoparticles’ Promises and Risks. Springer International Publishing Switzerland (2015). https://doi.org/10.1007/978-3-319-11728-7
Dykman, L.A., Khlebtsov, N.G.: Gold nanoparticles in biology and medicine: recent advances and prospects. Acta Naturae 3, 34–55 (2011)
Zhang, X.F., Liu, Z.G., Shen, W., Gurunathan, S.: Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches. Int. J. Mol. Sci. 17, 1534 (2016). https://doi.org/10.3390/ijms17091534
Ali, A., Zafar, H., Zia, M., ul Haq, I., Phull, A.R., Ali, J.S., Hussain, A.: Synthesis, characterization, applications, and challenges of iron oxide nanoparticles. Nanotechnol. Sci. Appl. 9, 49–67 (2016). https://doi.org/10.2147/NSA.S99986
Valizadeh, A., Mikaeili, H., Samiei, M., Farkhani, S.M., Zarghami, N., Kouhi, M., Akbarzadeh, A., Davaran, S.: Quantum dots: synthesis, bioapplications, and toxicity. Nanoscale Res. Lett. 7, 480 (2012). https://doi.org/10.1186/1556-276X-7-480
Pan, K., Zhong, Q.: Organic nanoparticles in foods: fabrication, characterization and utilization. Annu. Rev. Food Sci. Technol. 7, 245–266 (2016). https://doi.org/10.1146/annurev-food-041715-033215
Marcaccio, M., Paolucci, F., eds.: Making and exploiting fullerenes, graphene, and carbon nanotubes. Springer, Berlin, Heidelberg (2014). https://doi.org/10.1007/978-3-642-55083-6
Nasir, S., Hussein, M.Z., Zainal, Z., Yusof, N.A.: Carbon-based nanomaterials/allotropes: a glimpse of their synthesis, properties and some applications. Materials 11, 295 (2018). https://doi.org/10.3390/ma11020295
Feltracco, M., Barbaro, E., Contini, D., Zangrando, R., Toscano, G., Battistel, D., Barbante, C., Gambaro, A.: Photo-oxidation products of α-pinene in coarse, fine and ultrafine aerosol: a new high sensitive HPLC-MS/MS method. Atmos. Environ. 180, 149–155 (2018). https://doi.org/10.1016/j.atmosenv.2018.02.052
Kerminen, V.-M.: Roles of SO2 and secondary organics in the growth of nanometer particles in the lower atmosphere. J. Aerosol Sci. 30, 1069–1078 (1999). https://doi.org/10.1016/S0021-8502(98)00775-7
Tu, P., Johnston, M.V.: Particle size dependence of biogenic secondary organic aerosol molecular composition. Atmos. Chem. Phys. 17, 7593–7603 (2017). https://doi.org/10.5194/acp-17-7593-2017
Lindner, K., Ströbele M., Schlick, S., Webering, S., Jenckel, A., Kopf, J., Danov, O., Sewald, K., Buj, C., Creutzenberg, O., Tillmann, T., Pohlmann, G., Ernst, H., Ziemann, C., Hüttmann, G., Heine, H., Bockhorn, H., Hansen, T., König, P., Fehrenbach, H.: Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons. Part. Fibre Toxicol. 14, 8 (2017). https://doi.org/10.1186/s12989-017-0189-1
Ginoux, P., Chin, M., Tegen, I., Prospero, J.M., Holben, B., Dubovik, O., Lin, S.-J.: Sources and distributions of dust aerosols simulated with GOCART model. J. Geophys. Res. 106, 20255–20273 (2001). https://doi.org/10.1029/2000JD000053
D’Andrea, S.D., Häkkinen, S.A.K., Westervelt, D.M., Kuang, C., Levin, E.J.T., Kanawade, V.P., Leaitch, W.R., Spracklen, D.V., Riipinen, I., Pierce, J.R.: Understanding global secondary organic aerosol amount and size-resolved condensational behavior. Atmos. Chem. Phys. 13, 11519–11534 (2013). https://doi.org/10.5194/acp-13-11519-2013
Taghavi, S.M., Momenpour, M., Azarian, M., Ahmadian, M., Souri, F., Taghavi, S.A., Sadeghain, M., Karchani, M.: Effects of nanoparticles on the environment and outdoor workplaces. Electron. Physician 5, 706–712 (2013). https://doi.org/10.14661/2013.706-712
Rivero, P.J., Urrutia, A., Goicoechea, J., Arregui, F.J.: Nanomaterials for functional textiles and fibers. Nanoscale Res. Lett. 10, 501 (2015). https://doi.org/10.1186/s11671-015-1195-6
Blackford, D.B., Simons, G.R.: Particle size analysis of carbon black. Part. Charact. 4, 112–117 (1987). https://doi.org/10.1002/ppsc.19870040123
ICBA International Carbon Black Association. Carbon Black User’s Guide. www.carbon-black.org (2016)
SCCS Scientific Committee on Consumer Safety and Chaudhry Q. Opinion of the Scientific Committee on Consusmer Safety (SCCS)—Second revision of the opinion on carbon black, nano-form, in cosmetic products. Regul. Toxicol. Pharmacol. 79, 103–104 (2016). https://doi.org/10.1016/j.yrtph.2016.02.021
Suryanto, B.H.R., Zhao, C.: Surface-oxidized carbon black as a catalyst for the water oxidation and alcohol oxidation reactions. Chem. Commun. 52, 6439–6442 (2016). https://doi.org/10.1039/c6cc01319h
Yuan, L., Lu, X.-H., Xiao, X., Zhai, T., Dai, J., Zhang, F., Hu, B., Wang, X., Gong, L., Chen, J., Hu, C., Tong, Y., Zhou, J., Wang, Z.L.: Flexible solid-state supercapacitors based on carbon nanoparticles/MnO2 nanorods hybrid structure. ACS Nano 6, 656–661 (2012). https://doi.org/10.1021/nn2041279
Yuan, L., Tao, Y., Chen, J., Dai, J., Song, T., Ruan, M., Ma, Z., Gong, L., Liu, K., Zhang, X., Hu, X., Zhou, J., Wang, Z.L.: Carbon nanoparticles on carbon fabric for flexible and high-performance field emitters. Adv. Funct. Mater. 21, 2150–2154 (2011). https://doi.org/10.1002/adfm.201100172
Posthuma-Trumpie, G.A., Wichers, J.H., Koets, M., Berendsen, L.B.J.M., van Amerongen, A.: Amorphous carbon nanoparticles: a versatile label for diagnostic (immuno)assays. Anal. Bioanal. Chem. 402, 593–600 (2012). https://doi.org/10.1007/s00216-011-5340-5
Rosic, J.S., Conte, M., Muncan, J., Matija, L., Koruga, D.: Characterization of fullerenes thin film on glasses by UV/VIS/NIR and opto-magnetic imaging spectroscopy. FME Trans. 42, 172–176 (2014). https://doi.org/10.5937/fmet1402172S
Gatti, T., Menna, E., Meneghetti, M., Maggini, M., Petrozza, A., Lamberti, F.: The renaissance of fullerenes with perovskite solar cells. Nano Energy 41, 84–100 (2017). https://doi.org/10.1016/j.nanoen.2017.09.016
Liu, L., Niu, Z., Chen, J.: Unconventional supercapacitors from nanocarbon-based electrode materials to device configurations. Chem. Soc. Rev. 45, 4340–4363 (2016). https://doi.org/10.1039/c6cs00041j
Lv, T., Liu, M., Zhu, D., Gan, L., Chen, T.: Nanocarbon-based materials for flexible all-solid-state supercapacitors. Adv. Mater. 2018, 1705489 (2018). https://doi.org/10.1002/adma.201705489
Yong, Y., Zhou, Q., Li, X., Lv, S.: The H60Si6C54 heterofullerene as high-capacity storage medium. AIP Adv. 6, 075321 (2016). https://doi.org/10.1063/1.4960330
Yoon, M., Yang, S., Hicke, C., Wang, E., Geohegan, D., Zhang, Z.: Calcium as the superior coating metal in functionalization of carbon fullerenes for high-capacity hydrogen storage. Phys. Rev. Lett. 100, 206806 (2008). https://doi.org/10.1103/physrevlett.100.206806
Yoon, M., Yang, S., Wang, E., Zhang, Z.: Charged fullerenes as high-capacity hydrogen storage media. Nano Lett. 7, 2578–2583 (2007). https://doi.org/10.1021/nl070809a
Al-Jumaili, A., Alancherry, S., Bazaka, K., Jacob, M.V.: Review on the antimicrobial properties of carbon nanostructures. Materials 10, 1066 (2017). https://doi.org/10.3390/ma10091066
Teradal, N.L., Jelinek, R.: Carbon nanomaterials in biological studies and biomedicine. Adv. Healthc. Mater. 6, 1700574 (2017). https://doi.org/10.1002/adhm.201700574
De Smet, R., Demoor, T., Verschuere, S., Dullaers, M., Ostroff, G.R., Leclerq, G., Allais, L., Pilette, C., Dierendonck, M., De Geest, B.G., Cuvelier, C.A.: β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J. Control Rel. 172, 671–678 (2013). https://doi.org/10.1016/j.jconrel.2013.09.007
des Rieux, A., Fievez, A., Garinot, M., Schneider, Y.-J., Préat, V.: Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control Rel. 116, 1–27 (2006). https://doi.org/10.1016/j.jconrel.2006.08.013
Zhu, Q., Talton, J., Zhang, G., Cunningham, T., Wang, Z., Waters, R.C., Kirk, J., Eppler, B., Klinman, D.M., Sui, Y., Gagnon, S., Belyakov, I.M., Mumper, R.J., Berzofsky, J.A.: Large intestine-targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection. Nat. Med. 18, 1291–1297 (2012). https://doi.org/10.1038/nm.2866
Fonte, P., Nogueira, T., Gehm, C., Ferreira, D., Sarmento, B.: Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Deliv. Transl. Res. 1, 299–308 (2011). https://doi.org/10.1007/s13346-011-0023-5
Ren, T., Wang, Q., Xu, Y., Cong, L., Gou, J., Tao, X., Zhang, Y., He, H., Yin, T., Zhang, H., Zhang, Y., Tang, X.: Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles. J. Control Rel. 269, 423–438 (2018). https://doi.org/10.1016/j.jconrel.2017.11.015
Sun, S., Liang, N., Gong, X., An, W., Kawashima, Y., Cui, F., Yan, P.: Multifunctional composite microcapsules for oral delivery of insulin. Int. J. Mol. Sci. 18, 54 (2017). https://doi.org/10.3390/ijms18010054
Niu, Z., Conejos-Sánchez, I., Griffin, B.T., O’Driscoll, C.M., Alonso, M.J.: Lipid-based nanocarriers for oral peptide delivery. Adv. Drug Deliv. Rev. 106 Part B, 337–354 (2016). https://doi.org/10.1016/j.addr.2016.04.001
Sheng, Y., He, H., Zou, H.: Poly(lactic acid) nanoparticles coated with combined WGA and water-soluble chitosan for mucosal delivery of β-galactosidase. Drug Deliv. 21, 370–378 (2014). https://doi.org/10.3109/10717544.2014.905653
Yin, Y.S., Chen, D.W., Qiao, M.X., Wei, X.Y., Hu, H.Y.: Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution. J. Control Rel. 123, 27–38 (2007). https://doi.org/10.1016/j.jconrel.2007.06.024
Menzel, C., Bernkop-Schnürch, A.: Enzyme decorated drug carriers: targeted swords to cleave and overcome the mucus barrier. Adv. Drug Deliv. Rev. 124, 164–174 (2018). https://doi.org/10.1016/j.addr.2017.10.004
Frøkjær, J.B., Drewes, A.M., Gregersen, H.: Imaging of the gastrointestinal tract-novel technologies. World J. Gastroenterol. 15, 160–168 (2009). https://doi.org/10.3748/wjg.15.160
Stark, D.D., Weissleder, R., Elizondo, G., Hahn, P.F., Saini, S., Todd, L.E., Wittenberg, J., Ferrucci, J.T.: Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 168, 297–301 (1988). https://doi.org/10.1148/radiology.168.2.3393649
Shokrollahi, H.: Contrast agents for MRI. Mater. Sci. Eng. C 33, 4485–4497 (2013). https://doi.org/10.1016/j.msec.2013.07.012
Li, W., Tutton, S., Vu, A.T., Pierchala, L., Li, B.S.Y., Lewis, J.M., Prasad, P.V., Edelman, R.R.: First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel ultrasmall superparamagnetic iron oxide (USPIO)-based blood pool agent. J. Magn. Reson. Imaging 21, 46–52 (2005). https://doi.org/10.1002/jmri.20235
Frisch, A., Walter, T.C., Hamm, B., Denecke, T.: Efficacy of oral contrast agents for upper gastrointestinal signal suppression in MRCP: A systematic review of the literature. Acta Radiol. Open 6, 2058460117727315 (2017). https://doi.org/10.1177/2058460117727315
Maccioni, F., Bruni, A., Viscido, A., Colaiacomo, M.C., Cocco, A., Montesani, C., Caprilli, R., Marini, M.: MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent. Radiology 238, 517–530 (2006). https://doi.org/10.1148/radiol.2381040244
Gleich, B., Weizenecker, J.: Tomographic imaging using the nonlinear response of magnetic particles. Nature 435, 1214–1217 (2005). https://doi.org/10.1038/nature03808
Salamon, J., Hofmann, M., Jung, C., Kaul, M.G., Werner, F., Them, K., Reimer, R., Nielsen, P., vom Scheidt, A., Adam, G., Knopp, T., Ittrich, H.: Magnetic particle/magnetic resonance imaging: In-Vitro MPI-guided real time catheter tracking and 4D angioplasty using a road map and blood pool tracer approach. PLoS ONE 11, e0156899 (2016). https://doi.org/10.1371/journal.pone.0156899
Yu, E.Y., Chandrasekharan, P., Berzon, R., Tay, Z.W., Zhou, X.Y., Khandhar, A.P., Ferguson, R.M., Kemp, S.J., Zheng, B., Goodwill, P.W., Wendland, M.F., Krishnan, K.M., Behr, S., Carter, J., Conolly, S.M.: Magnetic particle imaging for highly sensitive, quantitative, and safe in vivo gut bleed detection in a murine model. ACS Nano 11, 12067–12076 (2017). https://doi.org/10.1021/acsnano.7b04844
Gamboa, J.M., Leong, K.W.: In vitro and in vivo models for the study of oral delivery of nanoparticles. Adv. Drug Deliv. Rev. 65, 800–810 (2013). https://doi.org/10.1016/j.addr.2013.01.003
Buhrke, T., Lengler, I., Lampen, A.: Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53, 411–426 (2011). https://doi.org/10.1111/j.1440-169X.2011.01258.x
Hidalgo, I.J., Raub, T.J., Borchardt, R.T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96, 736–749 (1989)
Sinnecker, H., Ramaker, K., Frey, A.: Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells. Beilstein J. Nanotechnol. 5, 2308-2315 (2014). https://doi.org/10.3762/bjnano.5.239
Béduneau, A., Tempesta, C., Fimbel, S., Pellequer, Y., Jannin, V., Demarne, F., Lamprecht, A.: A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure. Eur. J. Pharm. Biopharm. 87, 290–298 (2014). https://doi.org/10.1016/j.ejpb.2014.03.017
Mahler, G.J., Shuler, M.L., Glahn, R.P.: Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. J. Nutr. Biochem. 20, 494–502 (2009). https://doi.org/10.1016/j.jnutbio.2008.05.006
Kernéis, S., Bogdanova, A., Kraehenbuhl, J.-P., Pringault, E.: Conversion by Peyer’s patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277, 949–952 (1997). https://doi.org/10.1126/science.277.5328.949
Ahmad, T., Gogarty, M., Walsh, E.G., Brayden, D.J.: A comparison of three Peyer’s patch “M-like” cell culture models: particle uptake, bacterial interaction and epithelial histology. Eur. J. Pharm. Biopharm. 119, 426–436 (2017). https://doi.org/10.1016/j.ejpb.2017.07.013
des Rieux, A., Fievez, V., Théate, I., Mast, J., Préat, V., Schneider, Y.-J.: An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. Eur. J. Pharm. Sci. 30, 380–391 (2007). https://doi.org/10.1016/j.ejps.2006.12.006
Gullberg, E., Leonard, M., Karlsson, J., Hopkins, A.M., Brayden, D., Baird, A.W., Artursson, P.: Expression of specific markers and particle transport in a new human intestinal M cell model. Biochim. Biophys. Res. Commun. 279, 808–813 (2000). https://doi.org/10.1006/bbrc.2000.4038
Schimpel, C., Teubl, B., Absenger, M., Meindl, C., Fröhlich, E., Leitinger, G., Zimmer, A., Roblegg, E.: Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles. Mol. Pharm. 11, 808–818 (2014). https://doi.org/10.1021/mp400507g
Hilgers, A.R., Conradi, R.A., Burton, P.S.: Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res. 7, 902–910 (1990). https://doi.org/10.1023/A:1015937605100
Beloqui, A., des Lieux, A., Préat, V.: Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier. Adv. Drug Deliv. Rev. 106, Part B, 242–255 (2016). https://doi.org/10.1016/j.addr.2016.04.014
He, B., Lin, P., Jia, Z., Du, W., Qu, W., Yuan, L., Dai, W., Zhang, H., Wang, X., Wang, J., Zhang, X., Zhang, Q.: The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells. Biomaterials 34, 6082–6098 (2013). https://doi.org/10.1016/j.biomaterials.2013.04.053
Russel-Jones, G.J., Arthur, L., Walker, H.: Vitamin B12-mediated transport of nanoparticles across Caco-2 cells. Int. J. Pharm. 179, 247–255 (1999). https://doi.org/10.1016/S0378-5173(98)00394-9
Sheng, J., Han, L., Qin, J., Ru, G., Li, R., Wu, L., Cui, D., Yang, P., He, Y., Wang, J.: N-Trimethyl chitosan chloride-coated PLGA nanoparticles overcoming multiple barriers to oral insulin absorption. ACS Appl. Mater. Interfaces 7, 15430–15441 (2015). https://doi.org/10.1021/acsami.5b03555
Luo, Y., Teng, Z., Li, Y., Wang, Q.: Solid lipid nanoparticles for oral drug delivery: Chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake. Carbohydr. Polym. 122, 221–229 (2015). https://doi.org/10.1016/j.carbpol.2014.12.084
Araújo, F., Shrestha, N., Shahbazi, M.-A., Fonte, P., Mäkilä, E.M., Salonen, J.J., Hirvonen, J.T., Granja, P.L., Santos, H.A., Sarmento, B.: The impact of nanoparticles on the mucosal translocation and transport of GLP-1 across the intestinal epithelium. Biomaterials 35, 9199–9207 (2014). https://doi.org/10.1016/j.biomaterials.2014.07.026
Lichtenstein, D., Ebmeyer, J., Meyer, T., Behr, A.-C., Kästner, C., Böhmert, L., Juling, S., Nieman, B., Fahrenson, C., Selve, S., Thünemann, A.F., Meijer, J., Estrela-Lopis, I., Braeuning, A., Lampen, A.: It takes more than a coating to get nanoparticles through the intestinal barrier in vitro. Eur. J. Pharm. Biopharm. 118, 21–29 (2017). https://doi.org/10.1016/j.ejpb.2016.12.004
Giannasca, K.T., Giannasca, P.J., Neutra, M.R.: Adherence of Salmonella typhimurium to Caco-2 cells: identification of a glycoconjugate receptor. Infect. Immun. 64, 135–145 (1996)
Jahn, K.A., Biazik, J.M., Braet, F.: GM1 Expression in Caco-2 cells: characterisation of a fundamental passage-dependent transformation of a cell line. J. Pharmaceut. Sci. 100, 3751–3762 (2011). https://doi.org/10.1002/jps.22418
Behrens, I., Vila Pena, A.I., Alonso, M.J., Kissel, T.: Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res. 19, 1185–1193 (2002). https://doi.org/10.1023/A:10198543
Ke, Z., Guo, H., Zhu, X., Jin, Y., Huang, Y.: Efficient peroral delivery of insulin via vitamin B12 modified trimethyl chitosan nanoparticles. J. Pharm. Pharm. Sci. 18, 155–170 (2015)
Yoshida, T., Yoshioka, Y., Takahashi, H., Misato, K., Mori, T., Hirai, T., Nagano, K., Abe, Y., Mukai, Y., Kamada, H., Tsunoda, S., Nabeshi, H., Yoshikawa, T., Higashisaka, K., Tsutsumi, Y.: Intestinal absorption and biological effects of orally administered amorphous silica particles. Nanoscale Res. Lett. 9, 532–538 (2014). https://doi.org/10.1186/1556-276X-9-532
Wiwattanapatapee, R., Carreño-Gomez, B., Malik, N., Duncan, R.: Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system? Pharm. Res. 17, 991–998 (2000). https://doi.org/10.1023/A:1007587523543
Lautenschläger, I., Dombrowski, H., Frerichs, I., Kuchenbecker, S.C., Bade, S., Schultz, H., Zabel, P., Scholz, J., Weiler, N., Uhlig, S.: A model of the isolated perfused rat small intestine. Am. J. Physiol. 298, G304–G313 (2010). https://doi.org/10.1152/ajpgi.00313.2009
Sinnecker, H., Krause, T., Koelling, S., Lautenschläger, I., Frey, A.: The gut wall provides an effective barrier against nanoparticle uptake. Beilstein J. Nanotechnol. 5, 2092–2101 (2014). https://doi.org/10.3762/bjnano.5.218
Bergin, I.L., Witzmann, F.A.: Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps. Int. J. Biomed. Nanosci. Nanotechnol. 3, 163–210 (2013). https://doi.org/10.1504/ijbnn.2013.054515
Delie, F.: Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv. Drug Deliv. Rev. 34, 221–233 (1998). https://doi.org/10.1016/S0169-409X(98)00041-6
Bölke, T., Krapf, L., Orzekowsky-Schroeder, R., Vossmeyer, T., Dimitrijevic, J., Weller, H., Schüth, A., Klinger, A., Hüttmann, G., Gebert, A.: Data-adaptive image-denoising for detecting and quantifying nanoparticle entry in mucosal tissues through intravital 2-photon microscopy. Beilstein J. Nanotechnol. 5, 2016–2025 (2014). https://doi.org/10.3762/bjnano.5.210
Lee, C.-M., Lee, T.K., Kim, D.-I., Kim, Y.-R., Kim, M.-K., Jeong, H.-J., Sohn, M.-H., Lim, S.T.: Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration. Int. J. Nanomed. 9(Suppl 2), 243–250 (2014). https://doi.org/10.2147/ijn.s57938
Howe, S.E., Lickteig, D.J., Plunkett, K.N., Ryerse, J.S., Konjufca, V.: The uptake of soluble and particulate antigens by epithelial cells in the mouse small intestine. PLoS ONE 9, e86656 (2014). https://doi.org/10.1371/journal.pone.0086656
Loeschner, K., Hadrup, N., Qvortrup, K., Larsen, A., Gao, X., Vogel, U., Mortensen, A., Lam, H.R., Larsen, E.H.: Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate. Part. Fibre Toxicol. 8, 18 (2011). https://doi.org/10.1186/1743-8977-8-18
Jani, P., Halbert, G.W., Langridge, J., Florence, A.T.: Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821–826 (1990). https://doi.org/10.1111/j.2042-7158.1990.tb07033.x
Geraets, L., Oomen, A.G., Krystek, P., Jaobsen, N.R., Wallin, H., Laurentie, M., Verharen, H.W., Brandon, E.F.A., de Jong, W.H.: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part. Fibre Toxicol. 11, 30 (2014). https://doi.org/10.1186/1743-8977-11-30
Janer, G., Mas del Molino, E., Fernández-Rosas, E., Fernández, A., Vázquez-Campos, S.: Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol. Lett. 228, 103–110 (2014). https://doi.org/10.1016/j.toxlet.2014.04.014
Jovanovic, B.: Critical review of public health regulations of titanium dioxide, a human food additive. Integr. Environ. Assess. Manag. 11, 10–20 (2015). https://doi.org/10.1002/ieam.1571
Böckmann, J., Lahl, H., Eckert, T., Unterhalt, B.: Titan-Blutspiegel vor und nach Belastungsversuchen mit Titandioxid. Pharmazie 55, 140–143 (2000)
Jones, K., Morton, J., Smith, I., Jurkschat, K., Harding, A.-H., Evans, G.: Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles. Toxicol. Lett. 233, 95–101 (2015). https://doi.org/10.1016/j.toxlet.2014.12.005
Pele, L.C., Thoree, V., Bruggraber, S.F.A., Koller, D., Thompson, R.P.H., Lomer, M.C., Powell, J.J.: Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers. Part. Fibre Toxicol. 12, 26 (2015). https://doi.org/10.1186/s12989-015-0101-9
Rompelberg, C., Heringa, M.B., van Donkersgoed, G., Drijvers, J., Roos, A., Westenbrink, S., Peters, R., van Bemmel, G., Brand, W., Oomen, A.G.: Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population. Nanotoxicology 10, 1404–1414 (2016). https://doi.org/10.1080/17435390.2016.1222457
Weir, A., Westerhoff, P., Fabricius, L., Hristovski, K., von Goertz, N.: Titanium dioxide nanoparticles in food and personal care products. Environ. Sci. Technol. 46, 2242–2250 (2012). https://doi.org/10.1021/es204168d
Jani, P.U., McCarthy, D.E., Florence, A.: Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration. Int. J. Pharm. 105, 157–168 (1994). https://doi.org/10.1016/0378-5173(94)90461-8
Hummel, T.Z., Kindermann, A., Stokkers, P.C.F., Benninga, M.A., ten Kate, F.J.W.: Exogenous pigment in Peyer’s patches of children suspected of having IBD. J. Pediatr. Gastroenterol. Nutr. 58, 477–480 (2014). https://doi.org/10.1097/MPG.0000000000000221
Shepherd, N.A., Crocker, P.R., Smith, A.P., Levison, D.A.: Exogenous pigment in Peyer’s patches. Human Pathol. 18, 50–54 (1987). https://doi.org/10.1016/S0046-8177(87)80193-4
Feliu, N., Docter, D., Heine, M., Del Pino, P., Ashraf, S., Kolosnjaj-Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., Stauber, R.H., Parak, W.J.: In vivo degeneration and the fate of inorganic nanoparticles. Chem. Soc. Rev. 45, 2440–2457 (2016). https://doi.org/10.1039/C5CS00699F
Carambia, A., Freund, B., Schwinge, D., Bruns, O.T., Salmen, S.C., Ittrich, H., Reimer, R., Heine, M., Huber, S., Waurisch, C., Eychmüller, A., Wraith, D.C., Korn, T., Nielsen, P., Weller, H., Schramm, C., Lüth, S., Lohse, A.W., Heeren, J., Herkel, J.: Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice. J. Hepatol. 62, 1349–1356 (2015). https://doi.org/10.1016/j.jhep.2015.01.006
Jung, C.S.L., Heine, M., Freund, B., Reimer, R., Koziolek, E.J., Kaul, M.G., Kording, F., Schumacher, U., Weller, H., Nielsen, P., Adam, G., Heeren, J., Ittrich, H.: Quantitative activity measurements of brown adipose tissue at 7 T magnetic resonance imaging after application of triglyceride-rich lipoprotein 59Fe-superparamagnetic iron oxide nanoparticle: intravenous versus intraperitoneal approach. Invest. Radiol. 51, 194–202 (2016). https://doi.org/10.1097/RLI.0000000000000235
Wang, Y., Zhao, Y., Cui, Y., Zhao, Q., Zhang, Q., Musetti, S., Kinghorn, K.A., Wang, S.: Overcoming multiple gastrointestinal barriers by bilayer modified hollow mesoporous silica nanocarriers. Acta Biomater. 65, 405–416 (2018). https://doi.org/10.1016/j.actbio.2017.10.025
Bartelt, A., Bruns, O.T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M.G., Tromsdorf, U.I., Weller, H., Waurisch, C., Eychmüller, A., Gordts, P.L.S.M., Rinninger, F., Bruegelmann, K., Freund, B., Nielsen, P., Merkel, M., Heeren, J.: Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17, 200–205 (2011). https://doi.org/10.1038/nm.2297
Freund, B., Tromsdorf, U.I., Bruns, O.T., Heine, M., Giemsa, A., Bartelt, A., Salmen, S.C., Raabe, N., Heeren, J., Ittrich, H., Reimer, R., Hohenberg, H., Schumacher, U., Weller, H., Nielsen, P.: A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies. ACS Nano 6, 7318–7325 (2012). https://doi.org/10.1021/nn3024267
Kreyling, W.G., Hirn, S., Möller, W., Schleh, C., Wenk, A., Celik, G., Lipka, J., Schäffler, M., Haberl, N., Johnston, B.D., Sperling, R., Schmid, G., Simon, U., Parak, W.J., Semmler-Behnke, M.: Air-blood barrier translocation of tracheally instilled gold nanoparticles inversely depends on particle size. ACS Nano 8, 222–233 (2014). https://doi.org/10.1021/nn403256v
Schleh, C., Semmler-Behnke, M., Lipka, J., Wenk, A., Hirn, S., Schäffler, M., Schmid, G., Simon, U., Kreyling, W.G.: Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration. Nanotoxicology 6, 36–46 (2012). https://doi.org/10.3109/17435390.2011.552811
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Frey, A. et al. (2019). Fate and Translocation of (Nano)Particulate Matter in the Gastrointestinal Tract. In: Gehr, P., Zellner, R. (eds) Biological Responses to Nanoscale Particles. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-12461-8_12
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