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Mesenchymal Neoplasms

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Atlas of Intestinal Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

As in the stomach, gastrointestinal stromal tumors (GIST) comprise the majority of malignant mesenchymal neoplasms in the small and large intestine. In addition, there is a diverse array of other nonepithelial tumors, both benign and malignant. Many benign mucosal and submucosal mesenchymal neoplasms may present as colorectal polyps, and recognition of these entities can be useful in some situations to explain the endoscopic impression of a polyp in the absence of typical adenomatous or hyperplastic epithelial changes. Some mesenchymal lesions are entirely harmless in isolation but may indicate the presence of an underlying hereditary cancer syndrome. Recognizing these associations and flagging appropriate patients may prompt clinical genetic evaluation and modification of cancer surveillance protocols. This chapter reviews key histologic features of the most common mesenchymal neoplasms in the small and large intestine.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Aysegul Sari MD, Richard Kirsch MBChB, PhD & James Conner MD, PhD

  2. İzmir Katip Celebi University Ataturk Training and Research Hospital, İzmir, Turkey

    Aysegul Sari MD

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  1. Aysegul Sari MD
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  2. Richard Kirsch MBChB, PhD
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  3. James Conner MD, PhD
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Sari, A., Kirsch, R., Conner, J. (2019). Mesenchymal Neoplasms. In: Atlas of Intestinal Pathology. Atlas of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-12379-6_3

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  • DOI: https://doi.org/10.1007/978-3-030-12379-6_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-12377-2

  • Online ISBN: 978-3-030-12379-6

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