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Medical Management of LPR

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Abstract

Laryngopharyngeal reflux (LPR) is a disorder that may cause a variety of symptoms, including dysphagia, chronic cough, postnasal drip, hoarseness, and fatigue. These symptoms stem from gastroesophageal reflux disease (GERD), which is far more widely studied and also offers multiple treatment modalities compared to the understudied LPR. These approaches prove particularly relevant for patients who have failed lifestyle modifications and include pharmacotherapy ranging from proton-pump inhibitors and histamine-2 receptor antagonists to GABAB agonists and neuromodulators. In addition, relatively new and minimally invasive endoscopic techniques for addressing LPR include transoral incisionless fundoplication, radiofrequency ablation of the lower esophageal sphincter, and anterior fundoplication, any of which may provide patients with relief from symptoms of LPR.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai West and Mount Sinai St. Luke’s Hospitals, New York, NY, USA

    Justin Field

  2. Gastroenterology, Cedars-Sinai Medical Group, Los Angeles, CA, USA

    Deena Midani

  3. Independent Researcher, Brooklyn, NY, USA

    Yellowlees Douglas

  4. Division of Gastroenterology and Hepatology, Department of Medicine, Mount Sinai West and Mount Sinai St. Luke’s Hospitals, New York, NY, USA

    Michael S. Smith

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  2. Deena Midani
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Editors and Affiliations

  1. Division of Otolaryngology-Head & Neck Surgery, University of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA

    Nausheen Jamal

  2. Department of Head and Neck Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA

    Marilene B. Wang

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Field, J., Midani, D., Douglas, Y., Smith, M.S. (2019). Medical Management of LPR. In: Jamal, N., Wang, M. (eds) Laryngopharyngeal Reflux Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-12318-5_5

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